[1]张曾云鸥,吴媛媛,蔡新颖,等.特应性皮炎伴发寻常型鱼鳞病相关因素分析[J].中国皮肤性病学杂志,2021,(09):1038-1043.[doi:10.13735/j.cjdv.1001-7089.202010104]
 ZHANG Zengyunou,WU Yuanyuan,CAI Xinying,et al.Analysis of Related Factors in Atopic Dermatitis with Ichthyosis Vulgaris[J].The Chinese Journal of Dermatovenereology,2021,(09):1038-1043.[doi:10.13735/j.cjdv.1001-7089.202010104]
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特应性皮炎伴发寻常型鱼鳞病相关因素分析()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2021年09期
页码:
1038-1043
栏目:
调查报告
出版日期:
2021-09-01

文章信息/Info

Title:
Analysis of Related Factors in Atopic Dermatitis with Ichthyosis Vulgaris
文章编号:
1001-7089(2021)09-1038-06
作者:
张曾云鸥吴媛媛蔡新颖肖风丽
安徽医科大学第一附属医院皮肤性病科,皮肤病学教育部重点实验室,重大自身免疫性疾病安徽省重点实验室,安徽 合肥 230032
Author(s):
ZHANG ZengyunouWU YuanyuanCAI XinyingXIAO Fengli
(Department of Dermatology and Venereology,the First Affiliated Hospital of Anhui Medical University,the Key Laboratory of Dermatology,Ministry of Education,Inflammation and Immune Mediated Diseases Laboratory of Anhui Province,Hefei 230032,China)
关键词:
特应性皮炎 寻常型鱼鳞病 Logistic模型
Keywords:
Atopic dermatitis Ichthyosis vulgaris Logistic models
分类号:
R 758.2; R 758.52
DOI:
10.13735/j.cjdv.1001-7089.202010104
文献标志码:
A
摘要:
目的 研究中国汉族特应性皮炎(atopic dermatitis,AD)患者伴发寻常型鱼鳞病(ichthyosis vulgaris,IV)的影响因素,为AD诊治提供依据。方法 收集2005年11月-2015年5月在安徽医科大学第一附属医院皮肤科以及全国三十多家三甲医院的AD患者资料,通过SPSS 25.0软件对影响AD伴IV的相关因素进行单因素和二分类Logistic回归分析。结果 共有3 041例AD患者,伴发IV者582例(19.14%)。单因素分析结果,性别、年龄、地域、慢性反复性皮炎、家族特应史、出汗时瘙痒、疾病严重程度、白色划痕、干皮症、掌纹症、眶周黑晕、毛周角化症,在AD伴IV与不伴IV组间发病率差异有统计学意义(P<0.05)。二分类Logistic回归分析结果显示,年龄、北方地区、出汗时瘙痒和疾病严重程度与AD伴IV呈正相关(P< 0.05)。纳入校正因素后,年龄(≥18岁)、北方地区、出汗时瘙痒和AD疾病严重程度仍呈正相关(P< 0.05),其中疾病严重程度(中度OR=2.20,95%CI:1.37~3.53; 重度OR=2.97,95%CI:1.83~4.82)与AD伴IV相关最强。结论 年龄(≥18岁)、北方地区、出汗时瘙痒和疾病严重程度是AD伴IV的危险因素。
Abstract:
Objective To investigate the influencing factors of atopic dermatitis(AD)in Chinese Han patients accompanied with ichthyosis vulgaris(IV),providing a basis for diagnosis and treatment of AD.Methods The data of AD patients were collected from Department of Dermatology,the First Affiliated Hospital of Anhui Medical University and other 30 Class-A hospitals across the country from November 2005 to May 2015.The univariate analysis and Binary Logistic regression analysis were performed on influencing factors of AD accompanied with IV by SPSS 25.0 software.Results Of 3 041 AD patients,582 patients had IV(19.14%).The results of univariate analysis showed that there were significant difference in influencing factors for AD patients with IV in AD with IV group and AD without IV group,including gender,age,areas,chronic dermatitis,family history of AD,itching during sweating,disease severity of AD,white dermographism,xeroderma,hyperlinear palms,orbital darkening and keratosis pilaris(P<0.05).The results of binary Logistic regression revealed that age,areas,itching during sweating,and disease severity were positively correlated with AD accompanied with IV(P<0.05).After adjusting some factors,age(≥18 years),area of North China,itching during sweating,and disease severity had a positive correlation(P< 0.05); among them,the severity of disease had the strongest correlation with AD accompanied with IV(moderate OR=2.20,95%CI:1.37~3.53; severe OR=2.97,95%CI:1.83~4.82).Conclusion Age(≥18 years),areas of North China,itching during sweating,and disease severity are risk factors for AD with IV.

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备注/Memo

备注/Memo:
[基金项目] 国家自然科学基金(81972926); 安徽省学术和技术带头人及后备人选学术科研活动资助(2017D141)
[通信作者] 肖风丽,E-mail:xiaofengli@126.com
更新日期/Last Update: 2021-09-01