[1]韩珊珊,黄凯凯,甄庆育,等.HPV疫苗引起的多形红斑1例国内首报[J].中国皮肤性病学杂志,2021,(09):1024.[doi:10.13735/j.cjdv.1001-7089.202012068]
 HAN Shanshan,HUANG Kaikai,ZHEN Qingyu,et al.First Report of Erythema Multiforme Caused by HPV Vaccine in China[J].The Chinese Journal of Dermatovenereology,2021,(09):1024.[doi:10.13735/j.cjdv.1001-7089.202012068]
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HPV疫苗引起的多形红斑1例国内首报()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2021年09期
页码:
1024
栏目:
病例报告
出版日期:
2021-09-01

文章信息/Info

Title:
First Report of Erythema Multiforme Caused by HPV Vaccine in China
文章编号:
1001-7089(2021)09-1024-03
作者:
韩珊珊1黄凯凯1甄庆育1林颖12
1.广州中医药大学第二附属医院(广东省中医院)皮肤科,广东 广州 510120; 2.广东省中医药防治难治性慢病重点实验室,广东 广州 510120
Author(s):
HAN Shanshan1HUANG Kaikai1ZHEN Qingyu1LIN Ying12
(1.Department of Dermatology,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China; 2.Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases,Guangzhou 510120,China)
关键词:
HPV疫苗 不良反应 多形红斑
Keywords:
Human papillomavirus vaccination Adverse reaction Erythema multiforme
分类号:
R 758.2
DOI:
10.13735/j.cjdv.1001-7089.202012068
文献标志码:
A
摘要:
患者女,32岁,全身出现红斑、斑丘疹、水疱伴瘙痒10 d。皮肤科情况:躯干、四肢泛发粟粒至蚕豆大孤立或融合隆起性红斑、斑丘疹,部分红斑中央可见水疱,疱壁紧张,尼氏征(-),呈典型靶形损害特点。皮损组织病理示:表皮可见浆痂,表皮内水疱形成,表皮中可见坏死的角质形成细胞,上皮脚延长,基底层液化不明显,真皮乳头水肿,真皮浅深层血管及附属器周围均可见淋巴细胞浸润,伴散在嗜酸性粒细胞浸润。诊断:多形红斑。
Abstract:
A 32-year-old female presented with systemic erythema,maculopapules,blisters and pruritus for 10 days.Skin examination showed isolated or fused evelated erythema with the size of miliary to broad bean,and maculopapules on the trunk and limbs,and some blisters could be seen in the center of part of the erythema,with tense blister wall,and Nissl's sign(-),showing typical target-shaped damage characteristics.Skin histopathology revealed that scrusts were observed in the epidermis,blisters formed in the epidermis,and necrotic keratinocytes were observed in the epidermis,with lengthened epithelial foot,unobvious basal layer liquefaction,dermal papillary edema,and lymphocyte infiltration around the superficial deep dermal vessels and accessory organs,accompanied by scattered eosinophils infiltration.A diagnosis of erythema multiforme was made.

参考文献/References:

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备注/Memo

备注/Memo:
[基金项目] 广东省中医药防治难治性慢病重点实验室项目(2018B030322012)
[通信作者] 林颖,E-mail:13725137126@126.com
更新日期/Last Update: 2021-09-01