[1]王金容,张佩莲,黄虹,等.伴黏膜受累的成人线状IgA大疱性皮病1例并文献回顾[J].中国皮肤性病学杂志,2021,(09):1017-1020.[doi:10.13735/j.cjdv.1001-7089.202101217]
 WANG Jinrong,ZHANG Peilian,HUANG Hong,et al.Adult Linear IgA Bullous Dermatosis with Mucosal Involvement in one Case and Literature Review[J].The Chinese Journal of Dermatovenereology,2021,(09):1017-1020.[doi:10.13735/j.cjdv.1001-7089.202101217]
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伴黏膜受累的成人线状IgA大疱性皮病1例并文献回顾()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2021年09期
页码:
1017-1020
栏目:
病例报告
出版日期:
2021-09-01

文章信息/Info

Title:
Adult Linear IgA Bullous Dermatosis with Mucosal Involvement in one Case and Literature Review
文章编号:
1001-7089(2021)09-1017-04
作者:
王金容张佩莲黄虹杨瑾伍迪欧阳晓勇叶建州
云南省中医医院·云南省中医皮肤病专科医院,云南 昆明 650021
Author(s):
WANG JinrongZHANG PeilianHUANG HongYANG JinWU DiOUYANG XiaoyongYE Jianzhou
(Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming 650021,China)
关键词:
IgA大疱性皮病 线状 成人
Keywords:
IgA bullous dermatosis Linear Adult
分类号:
R 758.66
DOI:
10.13735/j.cjdv.1001-7089.202101217
文献标志码:
A
摘要:
患者女,35岁,躯干、四肢红斑、瘙痒半月,加重伴水疱3 d。皮损组织病理示:表皮下水疱,疱液见中性粒细胞,真皮中浅层血管内及周围见中性粒细胞浸润; 直接免疫荧光见IgA、IgG基底膜带线状沉积; 根据临床表现、组织病理学、免疫荧光诊断为成人线状IgA大疱性皮病。线状IgA大疱性皮病为少见的自身免疫性表皮下大疱病,成人临床表现多样化,易出现误诊。
Abstract:
A 35-year-old women presented with erythema and pruritus on her trunk and extremities for half a month,which was aggravated and with blistering for three days. Histopathology of the skin lesion showed subepidermal bulla, neutrophils in the blister fluid, and neutrophil infiltration in and around the superficial blood vessels in the dermis. Direct immunofluorescence demonstrated linear deposition of immunoglobulin A and G at the dermal-epidermal junction. Based on clinical,histopathological,and immunofluorescence findings,the diagnosis was Linear IgA bullous dermatosis. It is a rare autoimmune subepidermal bullous disease, and has diverse clinical manifestations, which is therefore more likely to be misdiagnosed.

参考文献/References:

[1] Hofmann SC,Voith U,Schönau V,et al.Plasmin plays a role in the in vitro generation of the linear IgA dermatosis antigen LADB97[J].J Invest Dermatol,2009,129(7):1730-1739.
[2] Matsuura K,Ujiie H,Hayashi M,et al.Linear IgA bullous dermatosis in a pregnant woman with autoantibodies to the non-collagenous 16a domain of type ⅩⅦ collagen[J].Acta Derm Venereol,2017,97(3):404-405.
[3] Ishii N.Prognostic factors of patients with linear IgA bullous dermatosis[J].Br J Dermatol,2017,177(1):212-222.
[4] Meriam T,Rima G,Neila F,et al.Linear IgA bullous dermatosis:A rare manifestation of amoxicillin-clavulanic acid treatment[J].Dermatol Ther,2020,33(6):e14187.
[5] Agrawal S,Khanna U,Fernandez AP,et al.Linear immunoglobulin a bullous dermatosis associated with ulcerative colitis[J].Am J Gastroenterol,2020,115(9):1384.
[6] Gottlieb J,Ingen-Housz-Oro S,Alexandre M,et al.Idiopa-thic linear IgA bullous dermatosis:prognostic factors based on a case series of 72 adults[J].Br J Dermatol,2017,177(1):212-222.
[7] 闫会昌,张航.成人线状IgA大疱性皮病4例及文献回顾[J].中国皮肤性病学杂志,2017,31(3):290-293.
[8] Madnani NA,Khan KJ.Linear IgA bullous dermatosis of childhood:Response to thalidomide[J].Indian J Dermatol Venereol Leprol,2010,76(4):427-429.
[9] Leyla E,Neslihan A,Taner Y.Successful treatment of a patient with linear IgA bullous dermatosis limited to oral,hypopharyngeal,and laryngeal mucosa with dapsone[J].Dermatol Ther,2020,33(6):e14127.

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备注/Memo

备注/Memo:
[基金项目] 云南中医药大学第一附属医院中医药防治皮肤病省创新团队(2019HC001)
[通信作者] 张佩莲,E-mail:mzczpl1968@163.com
更新日期/Last Update: 2021-09-01