[1]辅海平,孙强.浙江省桐乡市2005-2019年HIV/AIDS患者CD4+T淋巴细胞检测情况分析[J].中国皮肤性病学杂志,2021,(09):1007-1011.[doi:10.13735/j.cjdv.1001-7089.202102017]
 FU Haiping,SUN Qiang.Analysis of CD4+T Lymphocyte Test in Patients with HIV/AIDS in the Tongxiang City of Zhejiang Province from 2005 to 2019[J].The Chinese Journal of Dermatovenereology,2021,(09):1007-1011.[doi:10.13735/j.cjdv.1001-7089.202102017]
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浙江省桐乡市2005-2019年HIV/AIDS患者CD4+T淋巴细胞检测情况分析()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2021年09期
页码:
1007-1011
栏目:
性传播疾病
出版日期:
2021-09-01

文章信息/Info

Title:
Analysis of CD4+T Lymphocyte Test in Patients with HIV/AIDS in the Tongxiang City of Zhejiang Province from 2005 to 2019
文章编号:
1001-7089(2021)09-1007-05
作者:
辅海平孙强
浙江省桐乡市疾病预防控制中心,浙江 桐乡 314500
Author(s):
FU HaipingSUN Qiang
(Centers for Disease Control and Prevention in Tongxiang City,Tongxiang 314500,China)
关键词:
艾滋病病毒感染者/艾滋病患者 CD4+T淋巴细胞 随访 影响因素
Keywords:
HIV/AIDS CD4+T lymphocyte Follow-up Influencing factors
分类号:
R 512.91
DOI:
10.13735/j.cjdv.1001-7089.202102017
文献标志码:
A
摘要:
目的 了解桐乡市艾滋病感染者/艾滋病患者CD4+T淋巴细胞检测情况及影响因素分析。方法 利用目前我国的晚发现定义标准回顾性分析2005年1月1日-2019年12月31日桐乡市报告至全国传染病监测系统的HIV/AIDS病例数据资料,描述统计CD4+T淋巴细胞检测结果低于200个/μL的影响因素,用Kaplan-Meier法估计生存时间,Cox比例风险模型分析与生存状态有关的影响因素,并采用Log Rank、Breslow和Tarone-Ware三种检验方法分析治疗组与非治疗组的生存率是否存在组间差别,并绘制生存曲线。结果 2005-2019年桐乡市累计报告HIV病例531例,首次随访检测CD4+T淋巴细胞503例。其中,晚发现患者128例,平均年龄(47.32±12.63)岁,以小学及以下文化、异性传播、已婚有配偶及非浙江省户籍的男性为主,单因素分析显示,是否治疗、年龄、婚姻状况、文化程度及感染途径,是检测CD4+T淋巴细胞晚发现的影响因素,差异有统计学意义(P<0.05)。非治疗组的死亡风险高于治疗组(95%CI:7.818~356.526),首次CD4+T淋巴细胞计数检测水平<50个/μL组死亡风险高于50~200个/μL组(95%CI:1.843~61.030)。病例报告来源于术前检测(95%CI: 0.005~0.641)、其他体检人群检测(95%CI:0.121~0.016)为保护因素。未治疗组平均生存时间为(60.137±19.092)个月,治疗组的生存时间为(151.470±5.013)个月,差异有统计学意义(P<0.05)。结论 桐乡市2005-2019年晚发现比例低于平均水平,治疗是提高患者生存的保护因素,应进一步扩大对重点人群的艾滋病主动检测,提高检测力度,提早发现HIV感染者并积极纳入治疗体系。
Abstract:
Objective To explore CD4 +T lymphocyte test of HIV/AIDS in Tongxiang City and to analyze influencing factors.Methods Using the current definition criteria of late detection in China,a retrospective analysis of HIV/AIDS case data reported from January 1, 2015 to December 31, 2019 to the National Infectious Disease Surveillance System late detection was performed,and the influencing factors of statistical CD4 +T lymphocyte test results less than 200 cells/μL was described.Kaplan-Meier method was used to estimate survival time,and Cox proportional hazard model was used to analyze influencing factors related to survival status. Log Rank,Breslow,and Tarone-Ware were used to analyze whether there as a difference in survival rate between treatment and non-treatment groups, and a survival curve was drawn.Results From 2005 to 2019,a total of 531 HIV cases were reported in Tongxiang City,and 503 CD4 +T lymphocytes were tested at first follow-up. Of them, 128 cases were detected late,and their mean age was(47.32±12.63)years. They had primary school education and below,heterosexual transmission,and married couples with spouse and non-local household registration had a higher rate of late detection than other categories of population. Univariate analysis showed presence or absence of treatment,age,marital status,education,and infection pathways were influencing factors for late detection in CD4 +T lymphocytes, with statistically significant difference(P<0.05). The risk of death in the non-treatment group was higher than that in the treatment group(95%CI:7.818~356.526). The risk of death in the detection level(<50 cells/μL)group was higher than that in the(50~200 cells/μL)group(95%CI:1.843~61.030).Preoperative tests(95%CI:0.005~0.641),and other physical examination groups(95%CI:0.121~0.016)were protective factors. The average survival time of the non-treatment group was(60.137±19.092)months,and the survival time of the treatment group was(151.470±5.013)months, suggesting significant difference(P<0.05).Conclusion The proportion of late detection among newly diagnosed HIV/AIDS patients in Tongxiang City from 2005 to 2019 is lower than average level.Treatment is a protective factor to improve the survival of patients.Active AIDS testing among high risk population should be further expanded, testing should be increased, and HIV-infected patients should be detected early and actively included in the treatment system.

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备注/Memo

备注/Memo:
[基金项目] 十三五国家科技重大专项传染病规模化现场流行病学和干预研究(2017ZX 10105001)
更新日期/Last Update: 2021-09-01