[1]金玉梅,吴文娟,杨春艳,等.紧密连接蛋白Claudins与皮肤病发生相关性的研究进展[J].中国皮肤性病学杂志,2021,(03):329-332.[doi:10.13735/j.cjdv.1001-7089.201912054]
 JIN Yumei,WU Wenjuan,YANG Chunyan,et al.Advances in the Correlations between Claudins and Skin Diseases[J].The Chinese Journal of Dermatovenereology,2021,(03):329-332.[doi:10.13735/j.cjdv.1001-7089.201912054]
点击复制

紧密连接蛋白Claudins与皮肤病发生相关性的研究进展()
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2021年03期
页码:
329-332
栏目:
综述
出版日期:
2021-03-01

文章信息/Info

Title:
Advances in the Correlations between Claudins and Skin Diseases
文章编号:
1001-7089(2021)03-0329-04
作者:
金玉梅吴文娟杨春艳杨建婷何黎
昆明医科大学第一附属医院皮肤科,云南省皮肤病医院,云南 昆明 650032
Author(s):
JIN YumeiWU WenjuanYANG ChunyanYANG JiantingHE Li
(Department of Dermatology, First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan Province, Kunming 650032, China)
关键词:
Claudins 紧密连接 皮肤屏障
Keywords:
Claudins Tight junctions Skin barrier
分类号:
R 751
DOI:
10.13735/j.cjdv.1001-7089.201912054
文献标志码:
A
摘要:
皮肤作为人体的第一道防线,其屏障功能主要由角质层和颗粒层的紧密连接共同维持。Claudins是构成紧密连接结构最重要的组成成分,其表达异常导致的皮肤屏障功能受损,参与了多种皮肤疾病的发生发展。本文综述了Claudins在皮肤疾病中的研究进展,为进一步了解皮肤屏障功能在皮肤疾病中的重要作用、寻找恢复正常屏障结构的方案来治疗皮肤疾病提供一定的理论基础。
Abstract:
Skin acts as the first line of body's defense, its barrier function primarily maintained by the stratum corneum and tight junctions(TJs).The family of Claudins is the most important part of TJs, furthermore, abnormal Claudins' expression may involve in various skin diseases.In order to understanding the importance of skin barrier in disease, our paper reviewed the research progress of skin diseases related to Claudins in recent years.

参考文献/References:

[1] De Benedetto A, Kubo A, Beck LA.Skin barrier disruption: a requirement for allergen sensitization?[J].J Invest Dermatol, 2012,132(3 Pt 2):949-963.
[2] Yoshida K, Yokouchi M, Nagao K,et al.Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis[J].J Dermatol Sci, 2013,71(2):89-99.
[3] Furuse M, Hata M, Furuse K, et al.Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice[J].J Cell Biol, 2002,156(6):1099-1111.
[4] Bazzoni G, Dejana E.Endothelial cell-to-cell junctions molecular organization and role in vascular homeostasis[J].Physiol Rev, 2004(84):869-901.
[5] Brandner JM.Tight junctions and tight junction proteins in mammalian epidermis[J].Eur J Pharm Biopharm, 2009,72(2):289-294.
[6] Gonzalez-Mariscal L, Betanzos A, Nava P,et al.Tight junction proteins[J].Prog Biophys Mol Biol, 2003,81(1):1-44.
[7] Khan N, Asif AR.Transcriptional regulators of Claudins in epithelial tight junctions[J].Mediators Inflamm, 2015,2015:1-6.
[8] Milatz S.A novel Claudinopathy based on Claudin-10 mutations[J].Int J Mol Sci, 2019,20(21):5396.
[9] Ma J, Wang P, Liu Y, et al.Kruppel-like factor 4 regulates blood-tumor barrier permeability via ZO-1, occludin and claudin-5[J].J Cell Physiol, 2014,229(7):916-926.
[10] Zhao YY, Zhao LN, Wang P, et al.Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin[J].J Neurosci Res, 2015,93(12):1891-1902.
[11] Zeng Z,Li Y,Pan Y,et al.Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis[J].Nat Commun, 2018,9(1):5395.
[12] Pan P,Bai L,Hua X,et al.miR-155 regulates claudinl expression in humans with intestinal mucosa dysfunction after brain injury[J].Transplant Proc, 2019,51(10):3474-3480.
[13] Kirschner N, Rosenthal R, Furuse M, et al.Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes[J].J Invest Dermatol, 2013,133(5):1161-1169.
[14] Baek JH, Lee SE, Choi KJ, et al.Acute modulations in stratum corneum permeability barrier function affect claudin expression and epidermal tight junction function via changes of epidermal calcium gradient[J].Yonsei Med J, 2013,54(2):523-528.
[15] Visconti B, Paolino G, Carotti S, et al.Immunohistochemical expression of VDR is associated with reduced integrity of tight junction complex in psoriatic skin[J].J Eur Acad Dermatol Venereol, 2015,29(10):2038-2042.
[16] Lin YK, Chen HW, Leu YL, et al.Indigo naturalis upregulates claudin-1 expression in human keratinocytes and psoriatic lesions[J].J Ethnopharmacol, 2013,145(2):614-620.
[17] Pan Y, Tang S, Xu L, et al.Expression and correlation of interleukin-36γ, claudin-1 and claudin-7 in psoriasis[J].Indian J Dermatol Venereol Leprol, 2019,85(5):534-536.
[18] Visconti B, Paolino G, Carotti S, et al.Immunohistochemical expression of VDR is associated with reduced integrity of tight junction complex in psoriatic skin[J].J Eur Acad Dermatol Venereol, 2015,29(10):2038-2042.
[19] Gruber R, Bornchen C, Rose K, et al.Diverse regulation of claudin-1 and claudin-4 in atopic dermatitis[J].Am J Pathol, 2015,185(10):2777-2789.
[20] De Benedetto A, Rafaels NM, McGirt LY, et al.Tight junction defects in patients with atopic dermatitis[J].J Allergy Clin Immunol, 2011,127(3):773-786.
[21] Asad S, Winge MC, Wahlgren CF, et al.The tight junction gene Claudin-1 is associated with atopic dermatitis among Ethiopians[J].J Eur Acad Dermatol Venereol, 2016,30(11):1939-1941.
[22] Ryu WI, Lee H, Bae HC, et al.IL-33 down-regulates CLDN1 expression through the ERK/STAT3 pathway in keratinocytes[J].J Dermatol Sci, 2018,90(3):313-322.
[23] Kirschner N, Poetzl C, von den Driesch P, et al.Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines[J].Am J Pathol, 2009,175(3):1095-1106.
[24] Yuki T, Tobiishi M, Kusaka-Kikushima A, et al.Impaired tight junctions in atopic dermatitis skin and in a skin-equivalent model treated with interleukin-17[J].PLoS One, 2016,11(9):e0161759.
[25] Bergmann S, von Buenau B, Vidal YSS, et al.Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently[J].Sci Rep, 2020,10(1):2024.
[26] Yu HS, Kang MJ, Kwon JW, et al.Claudin-1 polymorphism modifies the effect of mold exposure on the development of atopic dermatitis and production of IgE[J].J Allergy Clin Immunol, 2015,135(3):827-830.
[27] Kim YE, Cho N, Cheon S, et al.Bortezomib, a proteasome inhibitor, alleviates atopic dermatitis by increasing claudin 1 protein expression[J].Biochem Biophys Res Commun, 2017,493(1):744-750.
[28] Yamaga K, Murota H, Tamura A, et al.Claudin-3 loss causes leakage of sweat from the sweat gland to contri-bute to the pathogenesis of atopic dermatitis[J].J Invest Dermatol, 2018,138(6):1279-1287.
[29] Suarez-Farinas M, Ungar B,Correa da Rosa J,et al.RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications[J].J Allergy Clin Immunol, 2015,135(5):1218-1227.
[30] Rozenblit M, Suarez-Farinas M, Shemer A, et al.Resi-dual genomic profile after cyclosporine treatment may offer insights into atopic dermatitis reoccurrence[J].J Allergy Clin Immunol, 2014,134(4):955-957.
[31] Jia Z, Wang X, Wang X, et al.Calycosin alleviates allergic contact dermatitis by repairing epithelial tight junctions via down-regulating HIF-1α[J].J Cell Mol Med, 2018,22(9):4507-4521.
[32] Meisser SS, Altunbulaki C, Bandier J, et al.Skin barrier damage after exposure to paraphenylenediamine[J].J Allergy Clin Immunol, 2020,145(2):619-631.
[33] Li J, Li Q, Geng S.All trans retinoic acid alters the expression of the tight junction proteins Claudin 1 and 4 and epidermal barrier function associated genes in the epidermis[J].Int J Mol Med, 2019,43(4):1789-1805.
[34] Kumari V, Timm K, Kuhl AA, et al.Impact of systemic alitretinoin treatment on skin barrier gene and protein expression in patients with chronic hand eczema[J].Br J Dermatol, 2016,175(6):1243-1250.
[35] Kopecki Z, Yang GN, Arkell RM, et al.Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering[J].J Pathol, 2014,232(5):541-552.
[36] Deng Z, Chen M, Xie H,et al.Claudin reduction may relate to an impaired skin barrier in rosacea[J].J Dermatol, 2019,46(4):314-321.
[37] Yang L, Lyu L, Wu W, et al.Genome-wide identification of long non-coding RNA and mRNA profiling using RNA sequencing in subjects with sensitive skin[J].Onco-target, 2017, 8(70):114894-114910.
[38] Luo J, Wang H, Chen H, et al.CLDN4 silencing promotes proliferation and reduces chemotherapy sensitivity of gastric cancer cells through activation of the PI3K/Akt signalling pathway[J].Exp Physiol,2020,105(6):979-988.
[39] Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, et al. Tight junctions and the regulation of gene expression[J].Semin Cell Dev Biol,2014,36:213-223.
[40] Xing T, Benderman LJ, Sabu S, et al.Tight junction protein claudin-7 is essential for intestinal epithelial stem cell self-renewal and differentiation[J].Cell Mol Gastroenterol Hepatol,2020,9(4):641-659.
[41] Liu H, Wang M, Liang N,et al.Claudin-9 enhances the metastatic potential of hepatocytes via Tyk2/Stat3 signaling[J].Turk J Gastroenterol,2019,30(8):722-731.

相似文献/References:

[1]潘云雷,方红.皮肤屏障功能的改变与银屑病[J].中国皮肤性病学杂志,2018,(12):1442.[doi:10.13735/j.cjdv.1001-7089.201710092]
 PAN Yunlei,FANG Hong.The Altered Functions of Epidermal Barrier and Psoriasis[J].The Chinese Journal of Dermatovenereology,2018,(03):1442.[doi:10.13735/j.cjdv.1001-7089.201710092]

备注/Memo

备注/Memo:
[基金项目] 云南省科技领军人才(2017HA010); 云南省临床皮肤免疫疾病临床医学研究中心(2019ZF012); 云南省科技人才和平台计划(2017HB044)
[通信作者] 何黎,E-mail:drheli2662@126.com
更新日期/Last Update: 2021-02-10