[1]李浩,徐桂娟,王强,等.合并HIV感染的银屑病患者12例临床分析[J].中国皮肤性病学杂志,2021,(03):283-287.[doi:10.13735/j.cjdv.1001-7089.202005107]
 LI Hao,XU Guijuan,WANG Qiang,et al.Clinical Analysis of 12 Cases of Psoriasis with HIV Infection[J].The Chinese Journal of Dermatovenereology,2021,(03):283-287.[doi:10.13735/j.cjdv.1001-7089.202005107]
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合并HIV感染的银屑病患者12例临床分析()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2021年03期
页码:
283-287
栏目:
临床经验
出版日期:
2021-03-01

文章信息/Info

Title:
Clinical Analysis of 12 Cases of Psoriasis with HIV Infection
文章编号:
1001-7089(2021)03-0283-05
作者:
李浩徐桂娟王强王凯波韩宪伟孙晓冬苏芳孙晓杰韩莹李铁男
沈阳市第七人民医院皮肤科,辽宁 沈阳 110003
Author(s):
LI Hao XU Guijuan WANG Qiang WANG Kaibo HAN Xianwei SUN Xiaodong SU Fang SUN Xiaojie HAN Ying LI Tienan
(Department of Dermatology, the Seventh Hospital of Shenyang, Shenyang 110003, China)
关键词:
银屑病 HIV 合并感染 临床特征 分析
Keywords:
Psoriasis HIV Coinfection Clinical features Analysis
分类号:
R 758.63; R 512.91
DOI:
10.13735/j.cjdv.1001-7089.202005107
文献标志码:
B
摘要:
目的 探讨合并HIV感染的银屑病患者临床特征。方法 收集2015年1月-2019年12月本院收治的12例合并HIV感染的银屑病患者的临床资料,进行回顾性分析。结果 12例患者中,寻常性银屑病6例,关节病型银屑病1例,脓疱型银屑病1例,红皮病型银屑病4例; 男女比例5:1; 银屑病病史平均(7.88±7.86)年,入院时病情加重平均(1.00±0.57)个月。银屑病皮疹累及头面部6例(50.00%)、躯干12例(100%)、四肢9例(75.00%)、掌跖及指(趾)甲6例(50.00%); 伴关节疼痛4例(33.33%)。患者头面、躯干、四肢处皮疹表现为典型的银屑病红斑鳞屑疹,与HIV阴性患者未见明显差异。银屑病PASI评分为(16.67±10.70)分。本次研究中接受治疗的9例患者,CD4+T淋巴细胞均低于正常值,CD4/CD8均低于正常范围,CD4+T淋巴细胞计数越低,病情越重。9例患者均予以复方甘草酸苷静滴,配合外用糖皮质激素药膏等治疗,其中6例患者口服阿维A胶囊20~30 mg/d,治疗有效,但皮疹未完全消退,无死亡病例。结论 本组合并HIV感染的银屑病患者12例中,男性居多,以寻常性银屑病为主; 患者掌跖及指(趾)甲更易受累; CD4+T淋巴细胞计数越少,银屑病皮疹越重; 此类患者早期治疗方案与一般银屑病患者相仿,皮疹难以完全消退,但存活率高。
Abstract:
Objective To explore the clinical features of psoriasis patients with HIV infection.Methods A total of 12 patients with psoriasis and HIV infected in our hospital from January 2015 to December 2019 were collected, and the results were analyzed.Results Among the 12 patients, 6 cases with psoriasis vulgaris, 1 case with psoriatic arthritis, 1 case with pustular psoriasis, 4 cases with erythrodermic psoriasis.The proportion of male to female was 5 to 1.The average course of psoriasis was(7.88±7.86)years; the average disease progression at admission was(1.00 ±0.57)months.On distribution of lesions, 6 cases(50.00%)involving the head, 12 cases(100%)involving the trunk, 9 cases(75.00%)involving the limbs, 6 cases(50.00%)involving the palms and fingernails, 4 cases(33.33%)with joints pain.The rashes on the head, trunk and limbs were typical erythema and scale, which was not significantly different from HIV-negative patients.The PASI score for psoriasis was(16.67±10.70).Total 9 patients were treated in this study, CD4 +T lymphocytes was lower than normal, and the ratio of CD4 to CD8was lower than normal.Nine cases were given intravenous compound glycyrrhizin, combined with topical glucocorticoid ointment, and 6 cases were treated with acitretin capsules at dose 20~30 mg/d.The treatment was effective, but the rash could not be completely resolved, there were no deaths.Conclusion In this study, the majority of patients are male, and with psoriasis vulgaris.The palms and fingernails were prone to abnormalities.The lower of the CD4+T lymphocyte count, the worse of the psoriasis.The early treatment for these patients was similar to ordinary psoriasis patients.It was difficult to resolve the rash completely, but the survival rate was high.

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更新日期/Last Update: 2021-02-10