[1]刘建中,邓霞,谭卫群,等.外用2%盐酸卡替洛尔和0.5%马来酸噻吗洛尔滴眼液治疗浅表性婴儿血管瘤临床观察[J].中国皮肤性病学杂志,2021,(03):277-282.[doi:10.13735/j.cjdv.1001-7089.202007183]
 LIU Jianzhong,DENG Xia,TAN Weiqun,et al.Topical 2% Carteolol Hydrochloride Eye Drops and 0.5% Timolol Maleate Eye Drops in the Treatment of Low or Medium Risk Infantile Hemangioma[J].The Chinese Journal of Dermatovenereology,2021,(03):277-282.[doi:10.13735/j.cjdv.1001-7089.202007183]
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外用2%盐酸卡替洛尔和0.5%马来酸噻吗洛尔滴眼液治疗浅表性婴儿血管瘤临床观察()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2021年03期
页码:
277-282
栏目:
临床经验
出版日期:
2021-03-01

文章信息/Info

Title:
Topical 2% Carteolol Hydrochloride Eye Drops and 0.5% Timolol Maleate Eye Drops in the Treatment of Low or Medium Risk Infantile Hemangioma
文章编号:
1001-7089(2021)03-0277-06
作者:
刘建中1邓霞2谭卫群3李萍12李建红1罗珍1朱思虹 1石航1
1.广东省深圳市儿童医院皮肤科,广东 深圳 518038; 2.深圳遵义医学院珠海校区,广东 珠海519041; 3.广东省深圳市儿童医院心血管内科,广东 深圳 518038
Author(s):
LIU Jianzhong1DENG Xia2TAN Weiqun 3LI Ping12 LI Jianhong 1 LUO Zhen1 ZHU Sihong 1 SHI Hang1
(1. Department of Dermatology, Shenzhen Children's Hospital, Shenzhen 518038, China; 2.Zhuhai Campus of Zunyi Medical College, Zhuhai 519041,China; 3.Department of Cardiology, Shenzhen Children's Hospital, Shenzhen 518038, China)
关键词:
卡替洛尔 噻吗洛尔 外用 中低风险 浅表性 增殖期 婴儿血管瘤
Keywords:
Carteolol Timolol Topical Low or medium and risk Superficial Proliferation phase Infantile hemangioma
分类号:
R 739.5
DOI:
10.13735/j.cjdv.1001-7089.202007183
文献标志码:
B
摘要:
目的 观察外用2%盐酸卡替洛尔滴眼液和0.5%马来酸噻吗洛尔滴眼液治疗中低风险、浅表性、增殖期婴儿血管瘤的疗效及安全性。方法 采用随机开放平行对照试验将240例患者分为卡替洛尔组和噻吗洛尔组,最后分析201例患者的临床资料,分别对治疗后1个月、3个月和6个月时的疗效及不良反应进行组内和组间比较。 结果 卡替洛尔组(105例)和噻吗洛尔组(96例)治疗后1个月、3个月、6个月时的有效率分别为 18.10%和22.92%、63.81%和83.33%、82.86%和91.67%,表明随着用药时间的延长,有效率逐渐增高,疗程和疗效呈正相关(P均=0.00)。两组在用药后1个月和6个月时的有效率差异无统计学意义(P均>0.05),表明两种药物的起效时间和远期疗效无明显差别。总不良反应发生率:卡替洛尔组为6.67%(7/105),噻吗洛尔组为4.17%(4/96),差异未见统计学意义(P>0.05)。湿疹和溃疡为常见局部不良反应,其中卡替洛尔组7例(湿疹5例、溃疡2例)、噻吗洛尔组4例(湿疹3例、溃疡1例)。仅噻吗洛尔组的1例患者出现一过性不完全性房室传导阻滞,两组均未出现其他系统不良反应。结论 2%盐酸卡替洛尔滴眼液和0.5%马来酸噻吗洛尔滴眼液局部治疗中低风险、浅表性、增殖期婴儿血管瘤疗效肯定,随用药时间的延长,疗效增加。湿疹为局部常见不良反应,长期使用极少发生系统不良反应。两药均可作为婴儿血管瘤的治疗选择。
Abstract:
Objective To compare the efficacy and safety of 2% carteolol eye drops and 0.5% timolol eye drops in the treatment of low or medium risk, proliferative superficial infantile hemangioma.Methods A randomized, open parallel controlled trial was conducted in 240 cases of infantile hemangioma which were divided into carteolol and timolol group.The efficacy and adverse reactions at 1 month, 3 months and 6 months after treatment were analyzed.Results A total of 201 cases were analyzed.The effective rates of carteolol group(105 cases)and timolol group(96 cases)at 1 month, 3 months and 6 months were 18.10%/22.92%, 63.81%/83.33% and 82.86%/91.67%, respectively.The course of treatment was positively correlated with the curative effect(P = 0.00).There was no statistical difference in the effective rate between the two groups at 1 month and 6 months(P > 0.05).The incidence of total adverse reactions was 6.67%(7/105)in the carteolol group and 4.17%(4/96)in the timolol group, with no statistical difference(P > 0.05).Eczema and ulcer were common local adverse reactions, of which 7 cases were in the carteolol group(5 cases eczema, 2 cases ulcer)and 4 cases were in the timolol group(3 cases eczema, 1 case ulcer).Only 1 patient in timolol group presented transient incomplete atrioventricular block, and no other systemic adverse reactions occurred in both groups.Conclusion Both 2% carteolol eye drops and 0.5% timolol eye drops are effective in topical therapy of infantile hemangioma with low or medium risk, superficial and proliferative phase.Eczema is a common adverse reaction.Adverse systemic reactions are rare.

参考文献/References:

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备注/Memo

备注/Memo:
[基金项目] 深圳市卫生和计划生育委员会(SZFZ2017065)
[通信作者] 李萍,E-mail: liping20081110@126.com
更新日期/Last Update: 2021-02-10