[1]任静,夏育民.TWEAK/Fn14信号在银屑病发病机制中的作用及潜在诊疗策略[J].中国皮肤性病学杂志,2021,(02):212-216.
 REN Jing,XIA Yumin.TWEAK/Fn14 Activation in the Pathogenesis of Psoriasis and Relevant Diagnostic and Therapeutic Strategies[J].The Chinese Journal of Dermatovenereology,2021,(02):212-216.
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TWEAK/Fn14信号在银屑病发病机制中的作用及潜在诊疗策略()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2021年02期
页码:
212-216
栏目:
综述
出版日期:
2021-02-01

文章信息/Info

Title:
TWEAK/Fn14 Activation in the Pathogenesis of Psoriasis and Relevant Diagnostic and Therapeutic Strategies
文章编号:
1001-7089(2021)02-0212-05
作者:
任静夏育民
西安交通大学第二附属医院皮肤科,陕西 西安710004
Author(s):
REN JingXIA Yumin
(Department of Dermatology,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)
关键词:
TWEAK Fn14 银屑病 角质形成细胞 炎症反应
Keywords:
TWEAK Fn14 Psoriasis Keratinocytes Inflammatory response
分类号:
R 758.63
文献标志码:
A
摘要:
银屑病是一种常见的慢性炎症性皮肤病,以角质形成细胞异常增殖与分化为重要特征,并涉及多种炎症因子介导的免疫反应机制。肿瘤坏死因子样细胞凋亡弱诱导剂(tumor necrosis factor-like weak inducer of apoptosis,TWEAK)通过与其受体成纤维细胞生长诱导因子14(fibroblast growth factor-inducible 14,Fn14)结合调控细胞增殖、死亡、分化或迁移,促进血管生成、炎性细胞浸润等。近年研究发现,银屑病炎症微环境下角质形成细胞高表达Fn14,TWEAK/Fn14信号激活后促进细胞增殖及相关炎症反应,某些亚型银屑病患者外周血中TWEAK值升高,且经过治疗后出现不同变化。本文将讨论TWEAK/Fn14信号在银屑病发病机制中的具体作用,并为银屑病的诊断与治疗提供潜在的策略。
Abstract:
Psoriasis is a common chronic inflammatory skin disease,characterized by abnormal proliferation and differentiation of keratinocytes.There are many types of inflammatory cytokines involved in the immune responses of psoriasis.As a proinflammatory cytokine,tumor necrosis factor-like weak inducer of apoptosis(TWEAK)acts through engaging the sole receptor fibroblast growth-inducing factor 14(Fn14).TWEAK/Fn14 activation modulates cell proliferation,death,differentiation and migration and enhances angiogenesis and infiltration of inflammatory cells.Recently,it was found that keratinocytes in the inflammatory microenvironment of psoriasis highly express Fn14 and TWEAK/Fn14 interaction induces cell proliferation and inflammatory responses.Serum TWEAK increases in patients with certain subtypes of psoriasis,and varies with some therapies.This review summarizes the role of TWEAK/Fn14 signals in the pathogenesis of psoriasis as well as the potential diagnostic and therapeutic approaches for patients.

参考文献/References:

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备注/Memo

备注/Memo:
[基金项目] 国家自然科学基金重点项目(81630081); 陕西省创新人才推进计划-科技创新团队(2019TD-034)
[通信作者] 夏育民,E-mail:xiayumin1202@163.com
更新日期/Last Update: 2021-02-01