[1]陈荣威,梁国雄.富血小板血浆联合氨甲环酸治疗黄褐斑疗效观察[J].中国皮肤性病学杂志,2021,(02):148-151.
 CHEN Rongwei,LIANG Guoxiong.Clinical Observation of Platelet-rich Plasma Combined with Tranexamic Acid in the Treatment of Melasma[J].The Chinese Journal of Dermatovenereology,2021,(02):148-151.
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富血小板血浆联合氨甲环酸治疗黄褐斑疗效观察()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2021年02期
页码:
148-151
栏目:
临床经验
出版日期:
2021-02-01

文章信息/Info

Title:
Clinical Observation of Platelet-rich Plasma Combined with Tranexamic Acid in the Treatment of Melasma
文章编号:
1001-7089(2021)02-0148-04
作者:
陈荣威梁国雄
中山市陈星海医院/广东医科大学附属中山医院皮肤性病科,广东 中山 528415
Author(s):
CHEN RongweiLIANG Guoxiong
(Department of Dermatology,the Affiliated Zhongshan Hospital of Guangdong Medical University,Zhongshan 528415,China)
关键词:
黄褐斑 富血小板血浆 氨甲环酸
Keywords:
Melasma Platelet-rich plasma Tranexamic acid
分类号:
R 758.42
文献标志码:
B
摘要:
目的 探讨富血小板血浆(PRP)联合氨甲环酸片治疗黄褐斑的临床疗效及安全性。方法 将入选的79例患者随机分为两组,对照组(39例)单纯口服氨甲环酸片治疗,疗程为3个月,治疗组(40例)在对照组基础上,联合PRP治疗,每月1次,共3次。治疗结束后比较两组临床疗效及不良反应,6个月后观察复发情况。结果 3个月后,治疗组和对照组mMASI评分较治疗前均有显著降低(P均<0.05),治疗组mMASI评分较对照组差异有统计学意义(P<0.05)。治疗组有效率(77.50%)高于对照组(56.41%),差异有统计学意义(P<0.05)。两组患者均未见明显不良反应。6个月后,两组复发率比较,差异有统计学意义(P<0.05)。结论 富血小板血浆联合氨甲环酸片治疗黄褐斑疗效及安全性均较好,复发率低。
Abstract:
Objective To investigate the clinical efficacy and safety of the combination therapy of platelet-rich plasma with tranexamic acid in patients with melasma.Methods A total of 79 patients with melasma were enrolled and randomly divided into 2 groups.In control group,39 patients were treated with tranexamic acid tablets for 3 months. In treatment group,40 patients were treated with PRP once a month,three times in total,except oral tranexamic acid tablets.After the treatment,the clinical efficacy and adverse reactions of the two groups were compared,and the recurrence was observed after 6 months.Results After three months treatment,the mMASI score of the treatment group and the control group were significantly lower than before treatment(P<0.05).The mMASI score of the treatment group was significantly different from that of the control group(P<0.05).The curative effect of the treatment group(77.50%)was higher than that of the control group(56.41%),and the difference was statistically significant(P<0.05).Course of treatment,the two groups had no significant adverse reactions.After 6 months,the recurrence rate between the two groups was statistically significant(P<0.05).Conclusion The combination therapy of platelet-rich plasma combined with tranexamic acid in the treatment of melasma significant effect,fewer adverse reactions and low recurrence rate.

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更新日期/Last Update: 2021-02-01