[1]刘雄彪,陈亚会.富马酸氯马斯汀联合盐酸奥洛他定治疗慢性荨麻疹临床观察[J].中国皮肤性病学杂志,2021,(01):120-c1cd9fc5-d3ed-4a59-b65b-8a8871b2ca3e/pdf.[doi:10.13735/j.cjdv.1001-7089.202004197]
 LIU Xiongbiao,CHEN Yahui.Observation of Clinical Efficacy of Clemastine Fumarate Combined with Olopatadine Hydrochloride in the Treatment of Chronic Urticaria[J].The Chinese Journal of Dermatovenereology,2021,(01):120-c1cd9fc5-d3ed-4a59-b65b-8a8871b2ca3e/pdf.[doi:10.13735/j.cjdv.1001-7089.202004197]
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富马酸氯马斯汀联合盐酸奥洛他定治疗慢性荨麻疹临床观察
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2021年01期
页码:
120-c1cd9fc5-d3ed-4a59-b65b-8a8871b2ca3e/pdf
栏目:
药物与临床
出版日期:
2021-01-01

文章信息/Info

Title:
Observation of Clinical Efficacy of Clemastine Fumarate Combined with Olopatadine Hydrochloride in the Treatment of Chronic Urticaria
文章编号:
1001-7089(2021)01-0120-03
作者:
刘雄彪陈亚会
天门市第一人民医院,湖北天门431700
Author(s):
LIU XiongbiaoCHEN Yahui
The First People's Hospital of Tianmen in Hubei Province,Tianmen 431700,China
关键词:
富马酸氯马斯汀 盐酸奥洛他定 慢性荨麻疹 联合疗法
Keywords:
Clemastine fumarate Olopatadine hydrochloride Chronic urticaria Combination therapy
分类号:
R 758.24
DOI:
10.13735/j.cjdv.1001-7089.202004197
文献标志码:
B
摘要:
目的 评价富马酸氯马斯汀联合盐酸奥洛他定治疗慢性荨麻疹的临床疗效及安全性。方法 将入选的90例患者随机分成两组各45例,对照组口服富马酸氯马斯汀口服溶液10 mL 2次/d; 治疗组在对照组基础上加用盐酸奥洛他定片5 mg,2次/d,疗程共8周。结果 治疗结束后,治疗组有效率(90.48%)明显高于对照组(72.09%),差异有统计学意义(P<0.05)。治疗结束1个月后,治疗组复发率(15.79%)明显低于对照组(38.71%),差异有统计学意义(P<0.05)。且两组患者不良反应轻微。结论 富马酸氯马斯汀联合盐酸奥洛他定治疗慢性荨麻疹安全、有效。
Abstract:
Objective To evaluate the efficacy and safety of clemastine fumarate combined with olopatadine hydrochloride in the treatment of chronic urticaria. Methods Ninety patients with chronic urticaria were randomly divided into two groups. All patients were given clemastine fumarate(10 mL,bid),and the treatment group(45 cases)were also given olopatadine hydrochloride(5 mg,bid)for 8 weeks. Results After 8 weeks of treatment,the effective rate of treatment group( 90.48% )was significantly higher than that of the control group(72.09%).One month after the end of treatment,the recurrence rate of the treatment group(15.79%)was significantly lower than that of the control group(38.71%),the differences were statistically significant(P<0.05).There were a few patients with mild adverse reactions in the two groups. Conclusion Treatment of clemastine fumarate combined with olopatadine hydrochloride shows good curative effect and less adverse reaction.

参考文献/References:

[1] Zuberbier T,Aberer W,Asero R,et al.The EAACI/GA2LEN/EDF/WAO guideline for the definition,classification,diagnosis and management of urticaria[J].Allergy,2018,73(7):1393-1414.
[2] Cornillier H,Giraudeau B,Munck S,et al.Chronic spontaneous urticaria in children - a systematic review on interventions and comorbidities[J].Pediatr Allergy Immunol,2018,29(3):303-310.
[3] 毛越苹,谭国珍,张楚怡,等.枸地氯雷他定片治疗慢性特发性荨麻疹有效性与临床安全性分析[J].中国皮肤性病学杂志,2014,28(9):974-976.
[4] 杨杰,杨悦.淋巴细胞、炎性因子及 D-二聚体检测在慢性荨麻疹诊断中的价值分析[J].皮肤病与性病,2020,42(1):78-79.
[5] 丁飞,鲁严. 慢性荨麻疹患者淋巴细胞指标、D-二聚体和炎性因子指标变化及预后分析[J].国际检验医学杂志,2019,40(6):670-673.
[6] 王胜,张嫦娥.富马酸氯马斯汀联合氯雷他定治疗小儿慢性荨麻疹观察[J].实用中西医结合临床,2019,19(8):45-47.
[7] 马珊珊,张炜.盐酸奥洛他定治疗慢性荨麻疹的疗效和安全性观察[J].临床皮肤科杂志,2019,48(5):305-307.
[8] 权中文,孟媛,刘瑞风,等.盐酸奥洛他定治疗慢性荨麻疹疗效观察及对外周血细胞因子水平的影响[J].山西医药杂志,2019,11(48):2800-2801.
[9] Sil A,Tripathi SK,Chaudhuri A,et al.Olopatadine versus levocetirizine in chronic urticaria:an observer-blind,randomized,controlled trial of effectiveness and safety[J].J Dermatol Treat,2013,24(6):466-472.
[10] 姚丽萍,杨春艳,叶田,等.消风散联合盐酸奥洛他定片治疗慢性荨麻疹疗效分析[J].临床医药文献杂志,2019,6(23):173.
[11] 尤敏.富马酸氯马斯汀联合复方甘草酸苷卡介菌多糖核酸治疗慢性荨麻疹疗效观察 [J].中国医学文摘·皮肤科学,2014,31(3):139-140.

更新日期/Last Update: 2021-01-10