[1]孙晨,杨苏,杨潇,等.湿包裹治疗儿童重度特应性皮炎的疗效观察[J].中国皮肤性病学杂志,2021,(01):37-ace1163c-e54a-4efc-90f4-d2a1ddc0196f/pdf.[doi:10.13735/j.cjdv.1001-7089.201912097]
 SUN Chen,YANG Su,YANG Xiao,et al.Efficacy of Wet-Wrap Treatment for Severe Childhood Atopic Dermatitis[J].The Chinese Journal of Dermatovenereology,2021,(01):37-ace1163c-e54a-4efc-90f4-d2a1ddc0196f/pdf.[doi:10.13735/j.cjdv.1001-7089.201912097]
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湿包裹治疗儿童重度特应性皮炎的疗效观察
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2021年01期
页码:
37-ace1163c-e54a-4efc-90f4-d2a1ddc0196f/pdf
栏目:
临床经验
出版日期:
2021-01-01

文章信息/Info

Title:
Efficacy of Wet-Wrap Treatment for Severe Childhood Atopic Dermatitis
文章编号:
1001-7089(2021)01-0037-05
作者:
孙晨杨苏杨潇谢骏逸张红叶李敏
南京医科大学附属儿童医院皮肤科,江苏南京210008
Author(s):
SUN ChenYANG SuYANG XiaoXIE JunyiZHANG HongyeLI Min
Department of Dermatology,Children's Hospital of Nanjing Medical University,Nanjing 210008,China
关键词:
湿包裹 特应性皮炎 儿童
Keywords:
Wet-wrap treatment Atopic dermatitis Child
分类号:
R 758.2
DOI:
10.13735/j.cjdv.1001-7089.201912097
文献标志码:
B
摘要:
目的 观察湿包裹(WWT)治疗儿童重度特应性皮炎(AD)的疗效和安全性。 方法 2018年9月-2019年9月在南京儿童医院皮肤科门诊诊断为重度AD的患儿(符合Williams诊断标准,SCORAD>50分)40例,随机分为WWT组(n=20)和传统治疗组(n=20)。WWT组采用0.1%糠酸莫米松乳膏联合2%莫匹罗星软膏行WWT,传统治疗组采用同样药物直接外用治疗,均连续治疗5 d。评估两组治疗前后患儿AD积分指数评分(SCORAD)及瘙痒程度直观模拟尺评分(VAS)的改善情况。结果 WWT组治疗前SCOARD评分和VAS评分分别为(62.53±7.33)分和(6.55±1.15)分,治疗后分别为(20.71±3.40)分和(0.35±0.49)分,较前显著下降(P<0.01)。 WWT组SCORAD评分下降分值为(41.83±6.61)分,显著高于传统治疗组(28.52±6.67)分(P<0.01); WWT组VAS评分下降分值为(6.20±1.28)分,与传统治疗组(5.50±1.28)分差异无统计学意义(P>0.05)。WWT组5例患儿主诉治疗过程中出现潮湿不适。结论 WWT治疗儿童重度AD起效快,不良反应少,疗效优于传统外用药物。
Abstract:
Objective To evaluate the efficacy and safety of wet-wrap treatment(WWT)for severe childhood atopic dermatitis(AD).Methods A total of 40 children with severe AD were enrolled from Department of Dermatology of Children's Hospital of Nanjing Medical University from September 2018 to September 2019,whose diagnosis was based on the Williams' diagnostic criteria and SCOR atopic dermatitis(SCORAD)score was more than 50. They were randomly divided into the WWT group(n=20)and the traditional topical group(n=20)to be treated with 0.1% mometasone furoate and 2% mupirocin by WWT or topical treatment only for 5 days. After each treatment,the changes of SCORAD and visual analog scale(VAS)scores were evaluated and compared. Results The SCORAD and VAS scores of the WWT group were 62.53±7.33 and 6.55±1.15 respectively before the treatment,and significantly decreased to 20.71±3.40 and 0.35±0.49 respectively after the treatment(P<0.01).The SCORAD scores reductions were significantly higher in the WWT group than that in the traditional topical group(41.83±6.61 vs. 28.52±6.67,P<0.01). No significant differences was observed in the VAS score reductions between two groups( 6.20±1.28 vs.5.50±1.28)(P䥺Symbol~@@0.05). Five patients in WWT group reported discomfort induced by wetness during the treatment.Conclusion WWT shows rapid efficacy and less adverse reactions in the treatment of severe childhood AD,and its therapeutic effect is superior to that of traditional topical treatment.

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备注/Memo

备注/Memo:
[通信作者] 李敏,E-mail:liminmuzhi@126.com
更新日期/Last Update: 2021-01-10