[1]王世宁,杨晓静,安国芝.IL-9在皮肤病发病机制中的研究进展[J].中国皮肤性病学杂志,2020,(11):1326-1330.[doi:10.13735/j.cjdv.1001-7089.201912114]
 WANG Shining,YANG Xiaojing,AN Guozhi.Research Progress of IL-9 in the Pathogenesis of Skin Diseases[J].The Chinese Journal of Dermatovenereology,2020,(11):1326-1330.[doi:10.13735/j.cjdv.1001-7089.201912114]
点击复制

IL-9在皮肤病发病机制中的研究进展()
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年11期
页码:
1326-1330
栏目:
综述
出版日期:
2020-11-01

文章信息/Info

Title:
Research Progress of IL-9 in the Pathogenesis of Skin Diseases
文章编号:
1001-7089(2020)11-1326-05
作者:
王世宁杨晓静安国芝
河北北方学院附属第一医院皮肤科,河北 张家口 075000
Author(s):
WANG ShiningYANG XiaojingAN Guozhi
Dermatology First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China
关键词:
IL-9 Th9 银屑病 特应性皮炎 黑素瘤 发病机制
Keywords:
IL-9 Th9 Psoriasis Atopic dermatitis Melanoma Pathogenesis
分类号:
R 751
DOI:
10.13735/j.cjdv.1001-7089.201912114
文献标志码:
A
摘要:
白细胞介素9(IL-9)是由不同免疫细胞产生的多效功能细胞因子。其来源包括肥大细胞,自然杀伤T淋巴(NKT)细胞,Th2,Th17,Treg和ILC2细胞,而IL-9的主要生产者是Th9细胞。IL-9为多效性促炎因子,其在过敏、抗炎及肿瘤免疫调节过程中均起作用。近年来研究发现IL-9参与银屑病、系统性红斑狼疮、特应性皮炎及黑素瘤等疾病的病理过程。本文就IL-9的生物学作用及其与皮肤疾病的相关性进行综述。
Abstract:
Interleukin 9(IL-9)is a pleiotropic functional cytokine produced by different immune cells.Sources of IL-9 include mast cells,natural killer T lymphocytes(NKT),Th2,Th17,Treg and ILC2 cells,while the main producers of IL-9 are Th9 cells.IL-9 is a multi-acting pro-inflammatory factor that plays an important role in allergies,anti-inflammatory and tumor immune regulation.In recent years,studies have found that IL-9 is involved in the pathological processes of psoriasis,systemic lupus erythematosus,atopic dermatitis,and melanoma.In this report,we review recent advances in the biological effects of IL-9 and its correlation with skin diseases.

参考文献/References:

[1] Rajamanickam A,Babu S.Determining the frequencies of Th9 Cells from whole blood[J].Methods Mol Biol,2017,1585:83-92.
[2] Rojas-Zuleta WG,Sanchez E.IL-9:function,sources,and detection[J].Methods Mol Biol,2017,1585:21-35.
[3] Angkasekwinai P.Allergic inflammation and atopic disease:role of Th9 cells[J].Methods Mol Biol,2017,1585:189-199.
[4] Gessner A,Blum H,Röllinghoff M.Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistantmice[J].Immunobiology,1993,189(5):419-35.
[5] Beriou G,Bradshaw EM,Lozano E,et al.TGF-beta induces IL-9 production from human Th17 cells[J].J Immunol,2010,185(1):46-54.
[6] Stassen M,Arnold M,Hültner L,et al.Murine bone marrow-derived mast cells as potent producers of IL-9:costimulatory function of IL-10 and kit ligand in the presence of IL-1[J].J Immunol,2000,164(11):5549-5555.
[7] Monteiro M,Agua-Doce A,Almeida CF,et al.IL-9 expression by invariant NKT cells is not imprinted during thymic development[J].J Immunol,2015,195(7):3463-3471.
[8] Shik D,Tomar S,Lee JB,et al.IL-9-producing cells in the development of IgE-mediated food allergy[J].Semin Immunopathol,2017,39(1):69-77.
[9] Gessner A,Blum H,Röllinghoff M.Differential regulation of IL-9-expressionafter infection with Leishmania major in susceptible and resistantmice[J].Immunobiology,1993,189(5):419-435.
[10] PetersC,Häsler R,Wesch D,et al.Human Vδ2 T cells are a major source of interleukin-9[J].Proc Natl Acad Sci U S A,2016,113(44):12520-12525.
[11] Malik S,Awasthi A.Transcriptional control of Th9 cells:role of foxo1 in interleukin-9 induction[J].Front Immunol,2018,9:995.
[12] Staudt V,Bothur E,Klein M,et al.Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells[J].Immunity,2010,33(2):192-202.
[13] Wong MT,Ye JJ,Alonso MN,et al.Regulation of human Th9 differentiation by type linterferons and IL-21[J].Inununol Ceil Bio I,2010,88(6):624-631.
[14] Benevides L,Costa RS,Tavares LA,et al.B lymphocyte induced maturation protein 1 controls T(H)9 cell development,IL-9 production,and allergic inflammation[J].J Allergy Clin Immunol,2019,143(3):1119-1130.
[15] Yazdani R,Shapoori S,Rezaeepoor M,et al.Features and roles of T helper 9 cells and interleukin 9 in immunological diseases[J].Allergol Immunopathol(Madr),2019,47(1):90-104.
[16] 李婷,温炬,朱超英,等.IL-9抗体对小鼠银屑病样皮损及IL-17和CCR6的影响[J].中国皮肤性病学杂志,2016,30(3):246-250.
[17] Singh TP,Schön MP,Wallbrecht K,et al.Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis[J].PLoS One,2013,8(1):e51752.
[18] Cardoso PR,Lima EV,Lima MM,et al.Clinical and cytokine profile evaluation in Northeast Brazilian psoriasis plaque-type patients[J].Eur Cytokine Netw,2016,27(1):1-5.
[19] 胡小平,陈办成,邵勇.IL-9和IL-10基因拷贝数与银屑病发病的相关性[J].中国麻风皮肤病杂志,2014,30(1):14-16.
[20] 高淑平.寻常型银屑病患者外周血Th9及IL-9的水平变化及意义[J].中国中西医结合皮肤性病学杂志,2018,17(3):211-214.
[21] Ciccia F,Guggino G,Ferrante A,et al.Interleukin-9 overexpression and Th9 polarization characterize the inflamed gut,the synovial tissue,and the peripheral blood of patients with psoriatic arthritis[J].Arthritis Rheumatol,2016,68(8):1922-1931.
[22] Guggino G,Ciccia F,Di Liberto D,et al.Interleukin(IL)-9/IL-9R axis drives γδ T cells activation in psoriatic arthritis patients[J].Clin Exp Immunol,2016,186(3):277-283.
[23] Ouyang H,Shi Y,Liu Z,et al.Increased interleukin 9 and CD4+IL-9+ T cells in patients with systemic lupus erythematosus[J].Mol Med Rep,2013,7(3):10317.
[24] 王玮,彭辉,李蕊.IL-9基因单核苷酸多态性与系统性红斑狼疮的相关性研究[J].中华疾病控制杂志,2013,17(7):574-577.
[25] Yang J,Li Q,Yang X,et al.Interleukin-9 is associated with elevated anti-double-stranded DNA antibodies in lupus-prone mice[J].Mol Med,2015,21(1):364-370.
[26] 胡小平,张杰,邵勇.IL-9和IL-10基因拷贝数变异与特应性皮炎发病相关性[J].中国皮肤性病学杂志,2014,28(3):253-256.
[27] Ma L,Xue HB,Guan XH,et al.Possible pathogenic role of T helper type 9 cells and interleukin(IL)-9 in atopic dermatitis[J].Clin Exp Immunol,2014,175(1):25-31.
[28] Hong CH,Chang KL,Wang HJ,et al.IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes:A plausible mechanism of IL-9R in atopic dermatitis[J].J Dermatol Sci,2015,78(3):206-214.
[29] Yang XR,Pfeiffer RM,Wheeler W,et al.Identification of modifier genes for cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations[J].Int J Cancer,2009,125(12):2912-2917.
[30] Fang Y,Chen X,Bai Q,et al.IL-9 inhibits HTB-72 melanoma cell growth through upregulation of p21 and TRAIL[J].J Surg Oncol,2015,111(8):969-974.
[31] Abdul-Wahid A,Cydzik M,Prodeus A,et al.Induction of antigen-specific TH 9 immunity accompanied by mast cell activation blocks tumor cell engraftment[J].Int J Cancer,2016,139(4):841-853.
[32] Zheng R,Qian L,Yu J,et al.Analysis of the changes in Th9 cells and related cytokines in the peripheral blood of spontaneous urticaria patients[J].Biomed Rep,2017,6(6):633-639.
[33] Wang H,Bai J,Luo Z, et al.Overexpression and varied clinical significance of Th9 versus Th17 cells in distinct subtypes of oral lichen planus[J].Arch Oral Biol,2017,80:110-116.
[34] Gutin L,Tammaro A,Fishelevich R,et al.Elevation of IL-9 in extreme patch test reactions suggests it is an inflammatory mediator in allergic contact dermatitis[J].Dermatitis,2016,27(1):35-36.
[35] de Sousa JR,Pagliari C,de Almeida DSM,et al.Th9 cytokines response and its possible implications in the immunopathogenesis of leprosy[J].J Clin Pathol,2017,70(6):521-527.
[36] Yao X,Zhao J,Kong Q,et al.Exogenous IL-9 ameliorates experimental autoimmune myasthenia gravis symptoms in rats[J].Immunol Invest,2018,47(7):712-724.

备注/Memo

备注/Memo:
[基金项目] 2019年度河北省医学科学研究指导性课题(20190896) [通信作者] 安国芝,E-mail:zjkanguozhi@163.com
更新日期/Last Update: 2020-11-16