[1]彭经.多发性皮肤非典型纤维黄色瘤1例[J].中国皮肤性病学杂志,2020,(11):1312-1314.[doi:10.13735/j.cjdv.1001-7089.201912135]
 PENG Jing.A Case of Multiple Cutaneous Atypical Fibroxanthoma[J].The Chinese Journal of Dermatovenereology,2020,(11):1312-1314.[doi:10.13735/j.cjdv.1001-7089.201912135]
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多发性皮肤非典型纤维黄色瘤1例()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年11期
页码:
1312-1314
栏目:
病例报告
出版日期:
2020-11-01

文章信息/Info

Title:
A Case of Multiple Cutaneous Atypical Fibroxanthoma
文章编号:
1001-7089(2020)11-1312-03
作者:
彭经
三峡大学第一临床医学院皮肤科,宜昌市中心人民医院皮肤科,湖北 宜昌 443000
Author(s):
PENG Jing
Department of Dermatology,the First College of Clinical Medical Science,Three Gorges University,Yichang Central People's Hospital,Yichang 443000,China
关键词:
非典型纤维黄色瘤 多发性
Keywords:
Atypical fibroxanthoma Multiple
分类号:
R 739.5
DOI:
10.13735/j.cjdv.1001-7089.201912135
文献标志码:
B
摘要:
患者女,71岁,全身多发皮肤结节6年余。皮损组织病理示:瘤体内可见大量梭形细胞、组织细胞及巨细胞,呈杂乱性生长,梭形细胞和组织细胞具有显著多形性,可见较多异常核分裂象。部分多核巨细胞的胞核排列呈花圈状。免疫组织化学示:肿瘤细胞阳性表达CD10、CD68,部分表达Ki-67(15%),不表达CD34、平滑肌肌动蛋白(SMA)、平滑肌结蛋白(Desmin)、S-100。诊断:非典型纤维黄色瘤。
Abstract:
A 71-year-old female presented multiple cutaneous nodules for more than 6 years.The histopathology showed that there were a large number of spindle cells,histiocytes and giant cells in the tumor,which grew disorderly.Spindle cells and histiocytes had significant pleomorphism and abnormal mitoses.Nuclei of some multinucleated giant cells were arranged in a wreath.Immunohistochemical profile revealed CD10(+),CD68(+),Ki-67 index 15%,CD34(-),SMA(-),desmin(-)and S-100(-).The diagnosis of atypical fibroxanthoma was made.

参考文献/References:

[1] Anderson HL,Joseph AK.A pilot feasibility study of a rare skin tumor database[J].Dermatol Surg,2007,33(6):693-696.
[2] Hussein MR.Atypical fibroxanthoma:new insights[J].Expert Rev Anticancer Ther,2014,14(9):1075-1088.
[3] Koch M,Freundl AJ,Agaimy A,et al.Atypical fibroxanthoma-histological diagnosis,immunohistochemical markers and concepts of therapy[J].Anticancer Res,2015,35(11):5717-5735.
[4] 马晓燕,石艳宏,高应芳,等.皮肤非典型性纤维黄色瘤5例临床病理分析[J].临床与实验病理学杂志,2018,34(5):560-562.
[5] Tolkachjov SN,Kelley BF,Alahdab F,et al.Atypical fibroxanthoma:Systematic review and meta-analysis of treatment with Mohs micrographic surgery or excision[J].J Am Acad Dermatol,2018,79(5):929-934.e6.
[6] Wollina U,Schönlebe J,Ziemer M,et al.Atypical fibroxanthoma:a series of 56 tumors and an unexplained uneven distribution of cases in southeast Germany[J].Head Neck,2015,37(6):829-834.
[7] Polcz MM,Sebaratnam DF,Fernández-Peñas P.Atypical fibroxanthoma management:Recurrence,metastasis and disease-specific death[J].Australas J Dermatol,2018,59(1):10-25.

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更新日期/Last Update: 2020-11-16