[1]明星,李秀翠,董强,等.寻常疣和跖疣HPV型别及与临床特征关系的差异性[J].中国皮肤性病学杂志,2020,(11):1233-1237.[doi:10.13735/j.cjdv.1001-7089.202001066]
 MING Xing,LI Xiucui,DONG Qiang,et al.A Study on the Difference of Human Papillomavirus Genotypes and Their Relationship with Clinical Characteristics of Common and Plantar Warts[J].The Chinese Journal of Dermatovenereology,2020,(11):1233-1237.[doi:10.13735/j.cjdv.1001-7089.202001066]
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寻常疣和跖疣HPV型别及与临床特征关系的差异性()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年11期
页码:
1233-1237
栏目:
论著
出版日期:
2020-11-01

文章信息/Info

Title:
A Study on the Difference of Human Papillomavirus Genotypes and Their Relationship with Clinical Characteristics of Common and Plantar Warts
文章编号:
1001-7089(2020)11-1233-05
作者:
明星1李秀翠2董强3宗丽娜1尹萌萌1王泽锟1葛芸1 李京1 梁龙1吕世超1
1.安徽医科大学解放军第306临床学院皮肤科,北京 100101; 2.北京大学生育健康研究所/北京大学公共卫生学院流行病与卫生统计学系,北京 100871; 3.浙江省皮肤病医院皮肤科,浙江 湖州 313200
Author(s):
MING Xing1 LI Xiucui2 DONG Qiang3 ZONG Lina1 YIN Mengmeng 1WANG Zekun1 GE Yun1 LI Jing1 LIANG Long1 LYU Shichao1
1.Department of Dermatology, 306th Clinical College of People's Liberation Army, Anhui Medical University, Beijing 100101, China; 2.Institute of Reproductive Health/Department of Epidemiology and Health Statistics, School of Public Health, Peking University, Beijing 100871, China; 3.Department of Dermatology, Zhejiang Provincial Institute of Dermatology, Huzhou 313200, China
关键词:
人乳头状瘤病毒 临床特征 PCR TA克隆
Keywords:
Human papillomavirus Warts Clinical characteristics PCR TA cloning
分类号:
R 752.5
DOI:
10.13735/j.cjdv.1001-7089.202001066
文献标志码:
A
摘要:
目的 探讨寻常疣和跖疣患者的主要HPV型别及与临床特征关系的差异。方法 记录患者的临床信息; 使用PCR、基因测序和TA克隆技术检测HPV型别,分别采用构成比和组间、组内卡方检验比较寻常疣和跖疣患者的主要HPV型别及与临床特征关系的差异。结果 mu属的HPV1和α属的HPV2、27和57是寻常疣和跖疣患者的共同主要型别,α属的HPV7是寻常疣患者的主要型别。HPV1型别跖疣患者除和HPV1型别寻常疣患者一样具有疣体单发、疼痛症状比例高的临床特征外,还具有更易感染青少年(≤17岁)、病程短(≤12个月)及疣体中等大小(0.5~1.0 cm)的临床特征。HPV7型别寻常疣好发于男性患者,HPV27型别寻常疣老年患者较HPV2、57型别寻常疣老年患者更多见。结论 寻常疣和跖疣患者的主要HPV型别及与临床特征的关系均存在差异。
Abstract:
Objective To investigate the differences in human papillomavirus(HPV)genotypes of common and plantar warts and their relation with clinical characteristics.Methods Patient details were recorded; PCR, gene sequencing and TA-cloning technique were adopted to detect HPV genotypes of common and plantar warts, then the differences in main HPV genotypes and their relation with clinical characteristics were compared by constituent ratio and Chi-square test between and within groups, respectively.Results HPV1(mu genus)and HPV2,27,57(α genus)were the main HPV genotypes of common and plantar warts, HPV7(α genus)was the main HPV genotype of common warts.HPV1-associated plantar warts were related not only to single wart and high incidence of pain arising in as HPV1-associated common warts, but also to adolescents(≤17 years), short duration(≤12 months)and medium size of warts(0.50~1 cm).HPV7 assosiated common warts preferentially occurred in men, and elderly patients with HPV27-associated common warts were more common than those with HPV2,57associated common warts.Conclusion The main HPV genotypes of common and plantar warts and their relationship with clinical characteristics show a distinct profile.

参考文献/References:

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[7] Chen SL, Tsao YP, Lee JW, et al.Characterization and analysis of human papilloma viruses of skin warts[J].Arch Dermatol Res,1993,285(8):460-465.
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相似文献/References:

[1]向华国,丘敏梅,欧雪峰,等.女性人乳头状瘤病毒与沙眼衣原体、解脲脲原体及淋病奈瑟氏菌感染的相关性[J].中国皮肤性病学杂志,2013,(07):30.
 XIANG Hua-guo,QIU Min-mei,OU Xue-feng,et al.The Correlation of Human Papilloma Virus with Chlamydia Trachomatis, Ureaplasma Urealyticum and Neisseria Gonorrhoeae Infection in Women[J].The Chinese Journal of Dermatovenereology,2013,(11):30.

备注/Memo

备注/Memo:
[基金项目] 首都临床特色应用研究(Z141107002514179) [通信作者] 吕世超,E-mail:lvshichao@sina
更新日期/Last Update: 2020-11-16