[1]薛欢,王佩茹,王秀丽.ω-3 多不饱和脂肪酸对皮肤肿瘤的作用及机制研究进展[J].中国皮肤性病学杂志,2020,(10):1201-1204.[doi:10.13735/j.cjdv.1001-7089.201911124]
 XUE Huan,WANG Peiru,WANG Xiuli.Research Advances on Omega-3 Polyunsaturated Fatty Acids in Cutaneous Carcinoma and Molecular Mechanisms[J].The Chinese Journal of Dermatovenereology,2020,(10):1201-1204.[doi:10.13735/j.cjdv.1001-7089.201911124]

ω-3 多不饱和脂肪酸对皮肤肿瘤的作用及机制研究进展()




Research Advances on Omega-3 Polyunsaturated Fatty Acids in Cutaneous Carcinoma and Molecular Mechanisms
1.安徽医科大学上海皮肤病临床学院,上海 200443; 2.同济大学医学院光医学研究所,上海市皮肤病医院,上海 200443
XUE Huan1WANG Peiru2WANG Xiuli2
1.Shanghai Skin Disease Clinical College of Anhui Medical University,Shanghai 200443,China; 2.Institute of Photomedicine,Shanghai Skin Disease Hospital,Tongji University School of Medicine,Shanghai 200443,China
ω-3多不饱和脂肪酸 皮肤肿瘤 免疫抑制 慢性炎症
Omega-3 olyunsaturated fatty acid Ctaneous carcinoma Imunosuppression Chronic inflammation
R 739.5
长期紫外线照射、慢性炎症、机体免疫紊乱状态等是皮肤肿瘤发生发展的重要机制。ω-3多不饱和脂肪酸(ω-3 PUFAs)是人体必需脂肪酸,可以通过调控磷脂酶A2活性、抑制环氧合酶及前列腺素的产生,而减轻皮肤炎症反应及缓解免疫抑制状态; 并且可增强皮肤对紫外线的抵抗力,减弱紫外线导致的DNA损伤,对皮肤肿瘤具有一定的抑制作用。本综述总结了有关ω-3 PUFAs对皮肤肿瘤的影响及其相关机制。
Long-term ultraviolet radiation,chronic inflammation and immune dysfunction are important mechanisms for the development of cutaneous carcinoma.Omega-3 polyunsaturated fatty acids(ω-3 PUFAs)are essential fatty acids.It can regulate the activity of phospholipase A2 and inhibit the production of COX2 and PGE2,thus alleviating the skin inflammation and immunosuppressive state.Besides,ω-3 PUFAs can also enhance the skin's resistance to ultraviolet radiation and weaken the DNA damage caused by ultraviolet radiation.In conclusion,ω-3 PUFAs have certain preventive effects on tumors.This review summarized the effects and molecular mechanisms of ω-3 PUFAs on cutaneous carcinoma.


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[基金项目] 国家自然科学基金(81872512,81872212); 上海市卫生计生系统优青计划(2017YQ066); 上海市卫计委重点课题(201640016)
[通信作者] 王秀丽,E-mail:wangxiuli_1400023@tongji.edu.cn
更新日期/Last Update: 2020-10-15