[1]黄新绿,杜娟,王芳,等.白癜风细胞免疫学发病机制及靶向免疫治疗新进展[J].中国皮肤性病学杂志,2020,(10):1197-1200.[doi:10.13735/j.cjdv.1001-7089.201911135]
 HUANG Xinlyu,DU Juan,WANG Fang,et al.Update of Cellular Immunity and Targeted Immunotherapy of Vitiligo[J].The Chinese Journal of Dermatovenereology,2020,(10):1197-1200.[doi:10.13735/j.cjdv.1001-7089.201911135]
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白癜风细胞免疫学发病机制及靶向免疫治疗新进展()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年10期
页码:
1197-1200
栏目:
综述
出版日期:
2020-10-01

文章信息/Info

Title:
Update of Cellular Immunity and Targeted Immunotherapy of Vitiligo
文章编号:
1001-7089(2020)10-1197-04
作者:
黄新绿杜娟王芳徐前喜丁晓岚
北京大学人民医院皮肤科,北京 100044
Author(s):
HUANG XinlyuDU JuanWANG FangXU QianxiDING Xiaolan
Department of Dermatology,Peking University People's Hospital,Beijing 100044,China
关键词:
白癜风 细胞免疫 靶向免疫治疗
Keywords:
Vitiligo Cellular immunity Targeted immunotherapy
分类号:
R 758.41
DOI:
10.13735/j.cjdv.1001-7089.201911135
文献标志码:
A
摘要:
白癜风是后天获得性色素脱失性皮肤病,以表皮黑素细胞缺失而出现皮肤和黏膜白斑为特征。自身免疫是白癜风发病的关键环节,近年来白癜风的细胞免疫学机制研究有了很多进展。在固有免疫中,HSP70备受关注。适应性免疫中CD8+细胞毒性T细胞及其上游γ干扰素通路被阐明,调节性T细胞、记忆性T细胞也被证实参与白癜风的发病。本文综述了近5年白癜风细胞免疫学机制的研究进展以及随之产生的靶向免疫治疗。
Abstract:
Vitiligo is an acquired depigmentary disorder characterized by circumscribed white macules in the skin and/or mucosae due to the absence of epidermal melanocytes.Autoimmunity,especially cellular immunity plays a very important role in the pathogenesis of vitiligo,and there has been a lot of progress in recent years.In innate immunity,the role of heat shock protein70(HSP70)has attracted much attention.While CD8+ cytotoxic T cells and interferon-γ pathways were elucidated in adaptive immunity,regulatory T cells and memory T cells have also been shown to be involved in the pathogenesis of vitiligo.In this review,we summarized the progress of cellular immunity and targeted immunotherapies of vitiligo in the past 5 years.

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备注/Memo

备注/Memo:
[通信作者] 丁晓岚,E-mail:Lancyding@126.com
更新日期/Last Update: 2020-10-15