[1]耿雯瑾,赵月婷,曾贞,等.肾源性系统性纤维化1例[J].中国皮肤性病学杂志,2020,(10):1170-1172.[doi:10.13735/j.cjdv.1001-7089.201910089]
 GENG Wenjin,ZHAO Yueting,ZENG Zhen,et al.A Case of Nephrogenic Systemic Fibrosis[J].The Chinese Journal of Dermatovenereology,2020,(10):1170-1172.[doi:10.13735/j.cjdv.1001-7089.201910089]
点击复制

肾源性系统性纤维化1例()
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年10期
页码:
1170-1172
栏目:
病例报告
出版日期:
2020-10-01

文章信息/Info

Title:
A Case of Nephrogenic Systemic Fibrosis
文章编号:
1001-7089(2020)10-1170-03
作者:
耿雯瑾1赵月婷1曾贞1陈凤娟2刘彤云1
1.昆明医科大学第一附属医院皮肤科,云南 昆明 650032; 2.上海市第六人民医院东院皮肤科,上海 201306
Author(s):
GENG Wenjin1ZHAO Yueting1ZENG Zhen1CHEN Fengjuan2LIU Tongyun1
1.Department of Dermatology,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China; 2.Department of Dermatology,Eastern Hospital of the Sixth People's Hospital of Shanghai,Shanghai 201306,China
关键词:
肾源性系统性纤维化 肾疾病 造影剂
Keywords:
Nephrogenic systemic fibrosis Kidney disease Contrast agents
分类号:
R 593.25
DOI:
10.13735/j.cjdv.1001-7089.201910089
文献标志码:
B
摘要:
患者男,49岁,双下肢皮肤红斑、变硬3个月,既往因慢性肾功能衰竭行肾移植术。皮肤科情况:双下肢大小不一片状、不规则肿胀性暗红斑,部分融合,边界不清,质硬,呈橘皮样。皮损组织病理示:真皮全层弥漫纤维化,延伸至皮下脂肪小叶间隔,并见梭形细胞增生。免疫组织化学:梭形细胞CD34阳性。诊断:肾源性系统性纤维化。
Abstract:
A 49-year-old male presented erythema and hardened skin on both lower extremities for three months,who underwent kidney transplantation due to chronic renal failure.Skin examination found the two lower extremities are uneven in size,irregularly swollen dark erythema,partially fused,with unclear borders,hard texture,and orange peel-like appearance.Histopathological examination showed the collagen bundles throughout the reticular dermis and extending into the septae of subcutaneous fat,and the proliferation of spindle cells.Immunostaining showed the spindle cells positivity for CD34.The diagnosis of nephrogenic systemic fibrosis was made.

参考文献/References:

[1] Cowper SE,Robin HS,Steinberg SM,et al.Scleromyxoedema-like cutaneous diseases in renal-dialysis patients[J].Lancet,2000,356(9234):1000-1001.
[2] Mark PB,Dekkers I,Blankestijn PJ,et al.European dermatology forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin,Part 2:Scleromyxedema,scleredema and nephrogenic systemic fibrosis[J].J Eur Acad Dermatol Venereol,2018,32(2):84-85.
[3] Todd DJ,Kay J.Gadolinium-induced fibrosis[J].Annu Rev Med,2016,67:273-291.
[4] Shah AH,Olivero JJ.Gadolinium-induced nephrogenic systemic fibrosis[J].Methodist Debakey Cardiovasc J,2017,13(3):172-173.
[5] Yee J.Prophylactic Hemodialysis for protection against gadolinium-induced nephrogenic systemic fibrosis:a Doll's House[J].Adv Chronic Kidney Dis,2017,24(3):133-135.
[6] Thomsen HS.Nephrogenic systemic fibrosis:a serious adverse reaction to gadolinium-1997-2006-2016.Part 2[J].Acta Radiol,2016,57(6):643-648.
[7] Wilson J,Gleghorn K,Seigel Q,et al.Nephrogenic systemic fibrosis:A 15-year retrospective study at a single tertiary care center[J].J Am Acad Dermatol,2017,77(2):235-240.

备注/Memo

备注/Memo:
[通信作者] 刘彤云,E-mail:tongyun91@126.com
更新日期/Last Update: 2020-10-15