[1]马璐,李进岚,赵廷方,等.贵州省81例麻风不良反应特征及相关因素分析[J].中国皮肤性病学杂志,2020,(10):1143-1148.[doi:10.13735/j.cjdv.1001-7089.201910012]
 MA Lu,LI Jinlan,ZHAO Tingfang,et al.Analysis of Adverse Reactions and Related Factors in 81 Cases of Leprosy in Guizhou Province[J].The Chinese Journal of Dermatovenereology,2020,(10):1143-1148.[doi:10.13735/j.cjdv.1001-7089.201910012]
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贵州省81例麻风不良反应特征及相关因素分析()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年10期
页码:
1143-1148
栏目:
临床经验
出版日期:
2020-10-01

文章信息/Info

Title:
Analysis of Adverse Reactions and Related Factors in 81 Cases of Leprosy in Guizhou Province
文章编号:
1001-7089(2020)10-1143-06
作者:
马璐1李进岚2赵廷方3刘洁2柯伟2刘航2王德2方楚龙2周健1佘敏1杨琴1
1.贵阳市疾病预防控制中心皮防科,贵州 贵阳 550003; 2.贵州省疾病预防控制中心结核病防治研所,贵州 贵阳 550004; 3.黔西南州疾病预防控制中心,贵州 兴义 562400
Author(s):
MA Lu1LI Jinlan2ZHAO Tingfang3LIU Jie2KE Wei2LIU Hang2WANG De2FANG Chulong2ZHOU Jian1SHE Min1YANG Qin1
1.Guiyang Center for Disease Control and Prevention,Guiyang 550003,China; 2.Guizhou Province Center for Disease Control and Prevention,Guiyang 550004,China; 3.Qianxinan Prefecture Center for Disease Control and Prevention,Xingyi 562400,China
关键词:
麻风 不良反应 特征
Keywords:
Leprosy Adverse reaction Characteristic
分类号:
R 755
DOI:
10.13735/j.cjdv.1001-7089.201910012
文献标志码:
B
摘要:
目的 了解麻风不良反应的发生特征及相关因素。方法 对贵州省81例登记麻风不良反应的麻风患者病历资料进行回顾性分析。结果 81例不良反应麻风患者中,Ⅰ型麻风反应12例(14.81%),Ⅱ型麻风反应41例(50.62%),混合型麻风反应9例(11.11%),单纯神经炎19例(23.46%)。40例(49.38%)麻风反应发生在联合化疗治疗前,26例(32.10%)发生在联合化疗中,15例(18.52%)发生在完成联合化疗后; Ⅰ型麻风反应、单纯神经炎发生多在开始MDT治疗1年内,Ⅱ型麻风反应多发生在MDT治疗结束后。神经损害均以双侧为主,尺神经炎发生率最高,为53.85%,麻风不良反应的发生与细菌指数有关(P<0.05)。结论 需进一步提高麻风不良反应的早期诊断水平,BI≥2.0的麻风患者、MDT治疗期间及治完后都要密切监测麻风不良反应的发生以减少麻风残疾的发生。
Abstract:
Objective To understand the characteristics and related factors of adverse reactions on leprosy.Methods A retrospective analysis of the medical records of 81 cases of leprosy patients with leprosy adverse reactions.Result Among 81 cases of ADR leprosy,12 cases(14.81%)had type Ⅰ leprosy reaction,41 cases(50.62%)had type Ⅱ leprosy reaction,9 cases(11.11%)had mixed leprosy reaction and 19 cases(23.46%)had simple neuritis.Forty cases(49.38%)of leprosy occurred before multi-drug therapy(MDT),26 cases(32.10%)occurred in MDT,and 15 cases(18.52%)occurred after MDT.Type Ⅰ leprosy reaction and simple neuritis mostly occurred within one year after starting MDT treatment,and type Ⅱ leprosy reaction occurred mostly after MDT treatment.The nerve damage was mainly bilateral,and the incidence of ulnar neuritis was the highest at 53.85%.The occurrence of adverse reactions of leprosy was related to bacterial index(P<0.05).Conclusion It is necessary to further improve the early diagnosis of adverse reactions of leprosy.The incidence of adverse reactions of leprosy should be closely monitored in leprosy patients with BI(≥2.0),during and after MDT treatment.

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备注/Memo

备注/Memo:
[基金项目] 国家自然科学基金(81260436)
[通信作者] 李进岚,E-mail:740820442@qq.com
更新日期/Last Update: 2020-10-15