[1]魏露,吴淑辉,张曦,等.石榴皮多酚乳膏对金黄地鼠皮脂腺斑LXRα/SREBP-1信号通路的影响[J].中国皮肤性病学杂志,2020,(10):1134-1138.[doi:10.13735/j.cjdv.1001-7089.202002044]
 WEI Lu,WU Shuhui,ZHANG Xi,et al.Experimental Study on Effect of Pomegranate Peel Polyphenol Cream on LXRα/SREBP-1 Signaling Pathway in Sebaceous Glands of Golden Hamsters[J].The Chinese Journal of Dermatovenereology,2020,(10):1134-1138.[doi:10.13735/j.cjdv.1001-7089.202002044]
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石榴皮多酚乳膏对金黄地鼠皮脂腺斑LXRα/SREBP-1信号通路的影响()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年10期
页码:
1134-1138
栏目:
论著
出版日期:
2020-10-01

文章信息/Info

Title:
Experimental Study on Effect of Pomegranate Peel Polyphenol Cream on LXRα/SREBP-1 Signaling Pathway in Sebaceous Glands of Golden Hamsters
文章编号:
1001-7089(2020)10-1134-05
作者:
魏露吴淑辉张曦朱明芳
湖南中医药大学第二附属医院,湖南 长沙 410005
Author(s):
WEI LuWU ShuhuiZHANG XiZHU Mingfang
The Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha 410005,China
关键词:
石榴皮多酚乳膏 痤疮 肝X受体α 固醇调节元件结合蛋白-1
Keywords:
Pomegranate peel polyphenol cream Acne Liver X receptor α Sterol regulatory element-binding protein-1
分类号:
R 758.73+3
DOI:
10.13735/j.cjdv.1001-7089.202002044
文献标志码:
A
摘要:
目的 观察石榴皮多酚乳膏对金黄地鼠皮脂腺斑肝X受体α(LXRα)/固醇调节元件结合蛋白-1(SREBP-1)信号通路的影响,探讨石榴皮多酚乳膏治疗痤疮的作用机制。方法 将24只金黄地鼠随机分为空白组、基质组、石榴皮多酚乳膏组、阳性对照组,共4组,每组6只,分别于双侧皮脂腺斑处涂抹蒸馏水、基质、石榴皮多酚乳膏、0.025%维A酸乳膏,连续给药4周后,观察各组金黄地鼠皮脂腺斑面积变化,免疫组织化学法检测局部组织中LXRα和SREBP-1蛋白表达水平。结果 各治疗组金黄地鼠皮脂腺斑LXRα和SREBP-1水平均明显低于空白组和基质组,差异有统计学意义(P<0.05),石榴皮多酚乳膏组与阳性对照组比较差异有统计学意义(P<0.05)。结论 石榴皮多酚乳膏治疗痤疮的作用机制可能与抑制LXRα/SREBP-1信号通路表达有关。
Abstract:
Objective To observe the effect of pomegranate peel polyphenol cream on Liver X receptor α(LXRα)/ sterol regulatory element-binding protein-1(SREBP-1)signaling pathway in sebaceous glands of golden hamsters,and to explore the mechanism of pomegranate peel polyphenol cream in the treatment of acne.Methods Twenty-four golden hamsters were randomly divided into blank group,matrix group,pomegranate peel polyphenol cream group and positive control group.As a result,four groups was set up with six in each.Distilled water,matrix,pomegranate polyphenol cream and 0.025% Vitamin A cream were applied to bilateral sebaceous gland spots.After continuous treatment for 4 weeks,observe the change of sebaceous gland area of golden hamster in each group and test the expression level of LXRα and SREBP-1 in local tissue by immunohistochemistry method.Results The level of LXRα and SREBP-1 in each treatment group were significantly lower than those in the blank group and the matrix group(P<0.05).There was statistically significant difference between the pomegranate peel polyphenol cream group and the positive control group(P<0.05).Conclusion Pomegranate peel polyphenol cream treatment of acne may be related to the inhibition of LXRα/ SREBP-1 signaling pathway.

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备注/Memo

备注/Memo:
[基金项目] 湖南省教育厅科学研究项目(18A212); 湖南省临床医疗技术创新引导项目(2018SK51102); 湖南省研究生科研创新项目(CX2018B501); 湖南省卫生健康委2020年度科研计划项目(20201862); 湖南省湖南省高层次卫生人才“225”工程培养项目
[通信作者] 朱明芳,E-mail:26715858@qq.com
更新日期/Last Update: 2020-10-15