[1]齐海花,黄占强,何磊,等.链球菌感染对儿童过敏性紫癜Th1/Th2失衡及预后的影响[J].中国皮肤性病学杂志,2020,(10):1131-1133.[doi:10.13735/j.cjdv.1001-7089.201911152]
 QI Haihua,HUANG Zhanqiang,HE Lei,et al.Effect of Streptococcal Infection on Th1/Th2 Imbalance and Prognosis in Children with Henoch-Schonlein Purpura[J].The Chinese Journal of Dermatovenereology,2020,(10):1131-1133.[doi:10.13735/j.cjdv.1001-7089.201911152]
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链球菌感染对儿童过敏性紫癜Th1/Th2失衡及预后的影响()
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年10期
页码:
1131-1133
栏目:
论著
出版日期:
2020-10-01

文章信息/Info

Title:
Effect of Streptococcal Infection on Th1/Th2 Imbalance and Prognosis in Children with Henoch-Schonlein Purpura
文章编号:
1001-7089(2020)10-1131-03
作者:
齐海花黄占强何磊刘利君陆海涛段昕所
承德医学院附属医院,河北 承德 067000
Author(s):
QI HaihuaHUANG ZhanqiangHE LeiLIU LijunLU HaitaoDUAN Xinsuo
Affiliated Hospital of Chengde Medical College,Chengde 067000,China
关键词:
链球菌感染 过敏性紫癜 Th1/Th2
Keywords:
Streptococcal infection Henoch-Schonlein purpura Th1/Th2
分类号:
R 725.5
DOI:
10.13735/j.cjdv.1001-7089.201911152
文献标志码:
A
摘要:
目的 探讨链球菌感染对儿童过敏性紫癜(HSP)Th1/Th2失衡及预后的影响。方法 选取链球菌感染引起的HSP患儿32例(感染组),非感染因素引起的HSP患儿35例(非感染组),同期本院健康体检儿童30例(对照组),采用酶联免疫吸附(ELISA)法检测各组外周血IL-2、INF-γ、IL-4、IL-10水平。同时比较两组患儿的并发症及复发情况。结果 两组患儿外周血IL-2、INF-γ水平均低于对照组,IL-4、IL-10水平均高于对照组,差异有统计学意义(P<0.05)。感染组与非感染组相比,感染组患儿外周血IL-2水平更低,IL-4、IL-10水平更高,差异有统计学意义(P<0.05); INF-γ水平差异无统计学意义(P>0.05)。感染组并发症及复发率均高于非感染组,差异有统计学意义(P<0.05)。结论 链球菌感染可能通过加重过敏性紫癜Th1/Th2失衡,影响预后。
Abstract:
Objective To investigate the effect of streptococcal infection on Th1/Th2 imbalance and prognosis in children with Henoch-Schonlein purpura(HSP).Methods Thirty-two children with HSP caused by streptococcal infection(infected group),35 children with non-infected HSP(non-infected group),and 30 healthy children(control group)were enrolled.The expression levels of IL-2,INF-γ,IL-4 and IL-10 in peripheral blood of each group were detected by enzyme-linked immunosorbent assay(ELISA).The complications and recurrence rate were compared between the two groups after treatment.Results The expression levels of IL-2 and INF-γ in the peripheral blood of the infected group and the non-infected group were lower than those of the control group,and the expression levels of IL-4 and IL-10 were higher than the control group,the difference was statistically significant(all P<0.05).Compared with the non-infected group,the expression level of IL-2 in the infected group was lower,and the expression levels of IL-4 and IL-10 were higher,the difference was statistically significant(all P<0.05).There was no significant difference in expression level of INF-γ between the two groups(P>0.05).The incidence of complications and recurrence rate were significantly higher in the infected group.The difference was statistically significant(P<0.05).Conclusion Streptococcal infection may affect the prognosis by aggravating the imbalance of Th1/Th2 in children with Henoch Schonlein purpura.

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备注/Memo

备注/Memo:
[基金项目]河北省承德市科技计划支撑项目(201701A044)
[通信作者]段昕所,E-mail:15633142680@163.com
更新日期/Last Update: 2020-10-15