[1]熊梦燎,李卉,周文明.皮肌炎和系统性红斑狼疮重叠综合征伴Degos样皮疹1例[J].中国皮肤性病学杂志,2020,(08):915-917.[doi:10.13735/j.cjdv.1001-7089.201909066]
 XIONG Mengliao,LI Hui,ZHOU Wenming.A Case of Degos-like Lesions in Systemic Lupus Erythematosus-Dermatomyositis Overlap Syndrome[J].The Chinese Journal of Dermatovenereology,2020,(08):915-917.[doi:10.13735/j.cjdv.1001-7089.201909066]
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皮肌炎和系统性红斑狼疮重叠综合征伴Degos样皮疹1例
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年08期
页码:
915-917
栏目:
病例报告
出版日期:
2020-07-28

文章信息/Info

Title:
A Case of Degos-like Lesions in Systemic Lupus Erythematosus-Dermatomyositis Overlap Syndrome
文章编号:
1001-7089(2020)08-0915-03
作者:
熊梦燎李卉周文明
安徽医科大学第一附属医院皮肤科,安徽医科大学皮肤病研究所,安徽 合肥 230032
Author(s):
XIONG MengliaoLI HuiZHOU Wenming
(Deparment of Dermatology,the First Affiliated Hospital of Anhui Medical University,Institute of Dermatology,Anhui Medical University,Hefei 230032,China)
关键词:
系统性红斑狼疮 皮肌炎 重叠综合征 Doges样皮疹
Keywords:
Systemic lupus erythematosus Dermatomyositis Overlap syndrome Degos-like lesions
分类号:
R 593.2; R 758.6
DOI:
10.13735/j.cjdv.1001-7089.201909066
文献标志码:
B
摘要:
患者男,45岁,面部、背部及四肢散在分布的红斑、丘疹4个月余。皮肤科情况:可见面部对称分布的红色斑片,背部、四肢弥漫分布的红色丘疹,丘疹中间凹陷,部分中央坏死,呈瓷白色萎缩斑。皮损组织病理示:表皮轻度角化过度伴表皮萎缩,基底细胞灶性液化变性,真皮浅层见色素失禁。真皮灶性胶原纤维增生。真皮血管壁坏死,管壁和周边浸润中性粒细胞及核尘,并见淋巴细胞和浆细胞浸润。予以甲泼尼龙、羟氯喹、阿司匹林、双嘧达莫等对症治疗后症状好转。
Abstract:
A 45-year-old male presented scattered erythema and papules on his face,back and limbs for more than 4 months.Physical examination showed the facial erythema are symmetrically distributed.The skin of the back and limbs had multiple papular lesions with central depression,central porcelain white atrophy and a peripheral rim of erythema.Pathology showed mild hyperkeratosis of epidermis with epidermal atrophy,focal liquefaction degeneration of basal cells,pigment incontinence in superficial dermis. Dermal focal collagen fibrous hyperplasia. Vascular wall necrosis in dermis,infiltration of neutrophils and nuclear dust in the wall and periphery,and infiltration of lymphocytes and plasma cells.Diagnosis: overlap syndrome with Degos-like lesions.Methylprednisolone,hydroxychloroquine,aspirin and dipyridamole were used successfully.

参考文献/References:

[1] Kim E,Kiran M. Benign atrophic papulosis(Degos disease)with lymphocytic vasculitis and lichen sclerosus-like features[J]. Am J Dermatopathol,2018,40(4):272-274.
[2] Jang MS,Park JB,Yang MH,et al. Degos-like lesions associated with systemic lupus erythematosus[J]. Ann Dermatol,2017,29(2): 215.
[3] Stavorn T,Kumutnart C. Degos-like lesions in association with connective tissue diseases: a report of three cases and literature review[J]. Clin Cosmet Investig Dermatol,2019,12:815-822.
[4] Magro CM,Poe JC,Kim C,et al. Degos disease: a C5b-9/interferon-alpha-mediated endotheliopathy syndrome[J]. Am J Clin Pathol,2011,135(4): 599-610.
[5] Dyrsen ME,Iwenofu OH,Nuovo G,et al. Parvovirus B19-associated catastrophic endothelialitis with a Degos-like presentation[J]. J Cutan Pathol,2008,35:20-25.
[6] Meephansan J,Komine M,Hosoda S,et al. Possible involvement of SDF-1/CXCL12 in the pathogenesis of Degos disease[J]. J Am Acad Dermatol,2013,68(1): 138-143.
[7] 吴晓蓓,苏美华,马天骄,等.趋化因子CXCL12/SDF-1及其受体CXCR4与系统性红斑狼疮的研究进展[J].中国社区医师,2015,31(11): 5-7.
[8] Day W,Gabriel C,Kelly RE Jr,et al. Juvenile dermatomyositis resembling late-stage Degos disease with gastrointestinal perforations successfully treated with combination of cyclophosphamide and rituximab: case-based review[J]. Rheumatol Int,2020. [Epub ahead of print]

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备注/Memo

备注/Memo:
[作者单位] 安徽医科大学第一附属医院皮肤科,安徽医科大学皮肤病研究所,安徽 合肥 230032
[通信作者] 周文明,E-mail:aydzwm@163.com
[Corresponding author] ZHOU Wenming,E-mail:aydzwm@163.com
[网络首发时间] 2020-5-14 16:14
[网络首发地址] http://kns.cnki.net/kcms/detail/61.1197.R.20200514.1320.001.html
更新日期/Last Update: 2020-07-28