[1]白瑶,石春蕊,董继元,等.兰州市区SO2、NO2浓度对荨麻疹日门诊人次的影响[J].中国皮肤性病学杂志,2020,(06):704-710.[doi:10.13735/j.cjdv.1001-7089.201906053]
 BAI Yao,SHI Chunrui,DONG Jiyuan,et al.Effects of SO2 and NO2 Concentration on the Number of Daily Outpatient Visits for Urticaria in Lanzhou[J].The Chinese Journal of Dermatovenereology,2020,(06):704-710.[doi:10.13735/j.cjdv.1001-7089.201906053]
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兰州市区SO2、NO2浓度对荨麻疹日门诊人次的影响
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年06期
页码:
704-710
栏目:
争鸣园地
出版日期:
2020-06-01

文章信息/Info

Title:
Effects of SO2 and NO2 Concentration on the Number of Daily Outpatient Visits for Urticaria in Lanzhou
文章编号:
1001-7089(2020)06-0704-07
作者:
白瑶1石春蕊2董继元3光奇4骆志成5郗群6何苑1
1.兰州大学第一临床医学院,甘肃 兰州 730000; 2.兰州大学第一医院皮肤科,甘肃 兰州 730000; 3.兰州大学公共卫生学院,甘肃 兰州 730000; 4.兰州大学第一医院信息中心,甘肃 兰州 730000; 5.兰州大学第二医院皮肤科,甘肃 兰州 730000; 6.兰州大学第二医院信息中心,甘肃 兰州 730000
Author(s):
BAI Yao1SHI Chunrui2DONG Jiyuan3GUANG Qi4LUO Zhicheng5XI Qun6HE Yuan1
(1.The First Clinical Medical College of Lanzhou University,Lanzhou 730000,China; /i>2.Department of Dermatology,the First Hospital of Lanzhou University,Lanzhou 730000,China; 3.School of Public Health,Lanzhou University,Lanzhou 730000,China; 4.Information Center,the First Hospital of Lanzhou University,Lanzhou 730000,China; 5.Department of Dermatology,Lanzhou University Second Hospital,Lanzhou 730000,China; 6.Information Center,Lanzhou University Second Hospital,Lanzhou 730000,China)
关键词:
荨麻疹 空气污染 二氧化硫 二氧化氮 分布滞后非线型模型 门诊就诊人次 分析
Keywords:
Urticaria Air pollution Sulfur dioxide Nitrogen dioxide Distributed lag nonlinear model Number of daily outpatient Analyze
分类号:
R 758.24
DOI:
10.13735/j.cjdv.1001-7089.201906053
文献标志码:
B
摘要:
目的 探讨兰州市气态污染物(SO2、NO2)与荨麻疹门诊人次的相关性,以及冷暖季、性别和年龄分层后不同人群对NO2、SO2的敏感性。方法 收集2013年1月18日-2017年12月31日荨麻疹患者的门诊记录,同期SO2、NO2浓度和气象资料。在控制长期趋势和星期几效应基础上,利用分布滞后非线型模型定量评估空气中SO2、NO2与荨麻疹日门诊就诊情况的暴露反应关系; 并按照不同人群建立模型。结果 研究期间,平均每日就诊荨麻疹患者(40.83±17.31)例; SO2、NO2平均浓度分别为24.14 μg/m3和43.69 μg/m3,经Spearman相关分析后发现荨麻疹日门诊人次与温度、相对湿度之间正相关,与SO2呈负相关; NO2与SO2两者之间为正相关。分析后发现SO2、NO2浓度变化和荨麻疹日门诊量之间呈正相关,NO2、SO2浓度每增加10 μg/m3,日门诊人次分别增加4.60%(95% CI:3.67%~5.53%)、3.15%(95% CI:1.84%~4.48%); 经性别和年龄分层后,NO2、SO2浓度每增加10 μg /m3,男性荨麻疹患者分别增加4.74%(95% CI:3.58%~5.90%)、3.92%(95% CI:2.30%~5.57%),0~18岁人群荨麻疹患者分别增加5.55%(95% CI:4.25%~6.87%)、5.58%(95% CI:3.70%~7.48%); 冷暖季分层后,冷季时NO2、SO2浓度每升高10 μg/m3荨麻疹日门诊人次分别增加5.15%(95%CI:1.06%~3.81%)、2.87%(95% CI:1.11%~4.67%)。结论 兰州地区SO2、NO2与荨麻疹日门诊人次之间呈正相关,各性别、年龄人群荨麻疹日门诊人次对SO2、NO2浓度变化的敏感程度也各不相同,且不同污染物在冷暖季对荨麻疹日门诊人次影响不同。
Abstract:
Objective To determine the relationship between gaseous pollutants SO2 and NO2 and daily outpatient visits for urticaria,and the sensitivity of different seasons,gender,and age groups to SO2 and NO2 in Lanzhou,China.Methods Data of daily urticaria outpatient visits,concentrations of SO2 and NO2 and meteorological variables during the period from January 18,2013 to December 31,2017 were collected.A distributed lag nonlinear model(DLNM)was used to analyse the exposure-effect relationship between SO2,NO2 and daily outpatient visits for urticaria,based on the control of long-term trends and “day of-week” effects.At the same time,the model was established based on the different groups.Results During the study period,the average daily patient visits were 40.83±17.31.The average concentrations of SO2 and NO2 were 24.14 μg/m3 and 43.69 μg/m3,respectively.The Spearman's correlations analysis showed that urticaria day outpatients' visits were positively correlated with temperature and relative humidity,whereas they were negatively correlated with SO2. NO2 was positively correlated with SO2.The analysis showed that urticaria day outpatients' visits were positively correlated with daily average SO2 and NO2 concentrations,specifically,a 10 μg/m3 increase of daily concentrations of NO2 and SO2 was associated with 4.60%(95% CI:3.67%~5.53%)and 3.15%(95% CI:1.84%~4.48%)increase in urticaria outpatient visits.Stratifying the patients according to gender and age,a 10 μg/m3 increase of daily concentrations of NO2 and SO2 were associated with the percentage increase of 4.74%(95% CI:3.58%~5.90%),3.92%(95% CI:2.30%~5.57%)and 5.55%(95% CI:4.25%~6.87%),5.58%(95% CI:3.70%~7.48%)for male and below the age of 18 hospital outpatient visits,respectively.After the cool and warm seasons stratification,a 10 μg/m3 increase of daily concentrations of NO2 and SO2 was associated with 5.15%(95%CI:1.06%~3.81%)and 2.87%(95%CI:1.11%~4.67%)increase in urticaria outpatient visits in the cool period.Conclusion SO2 and NO2 are positively associated with daily dermatological department visits for urticaria in Lanzhou,and the sensitivity of urticaria daily outpatient visits to changes in SO2 and NO2 concentrations varied among different genders and ages,and different pollutants had different effects on urticaria daily outpatient visits in cold and warm seasons.

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备注/Memo

备注/Memo:
[基金项目] 甘肃省自然科学基金项目(18JR3RA337)
[通信作者] 石春蕊,E-mail:stone7207@126.com
[Corresponding author]SHI Chunrui,E-mail:stone7207@126.com
更新日期/Last Update: 2020-06-05