[1]朱敬先,杨伟利,张利,等.皮肤淋巴管型孢子丝菌病1例[J].中国皮肤性病学杂志,2020,(06):670-673.[doi:10.13735/j.cjdv.1001-7089.201907010]
 ZHU Jingxian,YANG Weili,ZHANG Li,et al.A Case of Cutaneous Lymphatic Sporotrichosis[J].The Chinese Journal of Dermatovenereology,2020,(06):670-673.[doi:10.13735/j.cjdv.1001-7089.201907010]
点击复制

皮肤淋巴管型孢子丝菌病1例
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年06期
页码:
670-673
栏目:
病例报告
出版日期:
2020-06-01

文章信息/Info

Title:
A Case of Cutaneous Lymphatic Sporotrichosis
文章编号:
1001-7089(2020)06-0670-04
作者:
朱敬先杨伟利张利陈红蓓
河北医科大学第四医院,河北 石家庄 050011
Author(s):
ZHU JingxianYANG WeiliZHANG LiCHEN Hongbei
(Department of Dermatology,the Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,China)
关键词:
孢子丝菌病 球形孢子丝菌 扫描电镜 分子生物学
Keywords:
Sporotrichosis Sporothrix globosa Scanning electron microscope Molecular biology
分类号:
R 756
DOI:
10.13735/j.cjdv.1001-7089.201907010
文献标志码:
B
摘要:
患者男,48岁,菜农。右侧手背及前臂红色丘疹、结节,不伴痛痒1月余。发病前有外伤史。皮肤科情况:右侧手背及前臂可见数个红色丘疹、结节和溃疡,呈线状分布。真菌直接镜检阴性; 真菌培养见孢子丝菌复合体生长。组织病理呈感染性肉芽肿改变。扫描电镜可见分生孢子梗侧生或顶生分生孢子; 全壁芽生孢子在基底部产生横隔,脱落后遗留有齿状突起。分子生物学、构建系统发育进化树鉴定结果为球形孢子丝菌。给予患者口服伊曲康唑联合特比萘芬,外用卢立康唑乳膏,治疗2个月后明显好转。
Abstract:
A 48-year-old male farmer presented red papules and nodule on the back of right hand and forearm without pain or itching for more than one month.He had injury before falling ill.Physical examination revealed multiple red papules,nodules and ulcers arranged in a line on the back of right hand and forearm.The direct microscopic examination was negative for fungi.Fungal culture showed the growth of sporotrichosis complex.Histopathological examination showed infective granuloma.Scanning electron microscopy showed conidial or terminal conidia of the conidiophore; the whole wall blast spores produced a transverse septum at the base,leaving dentate after the shedding.According to the results of molecular biology and phylogenetic tree construction,sporothrix globosa was identified.The patient was treated with itraconazole combined with terbinafine orally and ruiconazole cream topically.The lesions were obviously improved after 2-month treatment.

参考文献/References:

[1] 李福秋,王爱平,冉玉平,等.孢子丝菌病诊疗指南[J].中国真菌学杂志,2016,49(7):456-459.
[2] Orofino-Costa R,Macedo PM,Rodrigues AM,et al.Sporotrichosis:an update on epidemiology,etiopathogenesis,laboratory and clinical therapeutics[J].An Bras Dermatol,2017,92(5):606-620.
[3] Sehoch CL,Seifert KA,Huhndorf S,et al.Nuclear ribosomal internal transcribed spacer
(ITS)region as a universal DNA barcode marker for fungi[J].Proe Natl Acad Sci USA,2012,109(16):6241-6246.
[4] Zhou X,Rodrigues AM,Feng P,et al.Global ITS diversity in the Sporothrix schenckii complex[J].Fungal Diversity,2014,66(1):153-165.
[5] Rodrigues AM,De Hoog GS,De Camargo ZP.Molecular diagnosis of pathogenic Sporothrix species[J].PLoS Negl Trop Dis,2015,9(12):e0004190.
[6] Rodrigues AM,De Hoog S,De Camargo ZP.Emergence of pathogenicity in the Sporothrix schenckii complex[J].Med Mycol,2013,51(4):405-412.
[7] Ottonelli Stopiglia CD,Magagnin CM,Castrillón MR,et al.Antifungal susceptibilities and identification of species of the Sporothrix schenckii complex isolated in Brazil[J].Med Mycol,2013,52(1):56-64.
[8] 景东云,王学军,彭琳琳,等.临床分离99株孢子丝菌病原体的分子和表型鉴定[J].中国皮肤性病学杂志,2015,29(3):231-234.
[9] Yu X,Wan Z,Zhang Z,et al.Phenotypic and molecular identification of Sporothrix isolates of clinical origin in Northeast China[J].Mycopathologia,2013,176(1-2):67-74.
[10] Liu T,Zhang K,Zhou X.Molecular identification of Sporothrix clinical isolates in China[J].J Zhejiang Univ Sci B,2014,15(1):100-108.
[11] 黄怀球,袁立燕,张静,等.申克孢子丝菌的扫描电镜观察[J].热点医学杂志,2012,12(12):1442-1443.

相似文献/References:

[1]黄圆圆,崔岩,郑华,等.耳部孢子丝菌病1例[J].中国皮肤性病学杂志,2016,(07):724.[doi:10.13735/j.cjdv.1001-7089.201601115]
 HUANG Yuan-yuan,CUI Yan,ZHENG Hua,et al.A Case of Auricular Sporotrichosis[J].The Chinese Journal of Dermatovenereology,2016,(06):724.[doi:10.13735/j.cjdv.1001-7089.201601115]
[2]杨洁*,周亚彬,万喆,等.皮肤固定型孢子丝菌病1例及其相关实验检查[J].中国皮肤性病学杂志,2018,(06):672.[doi:10.13735/j.cjdv.1001-7089.201706098]
 YANG Jie*,ZHOU Yabin,WAN Zhe,et al.A Case of Fixed Cutaneous Sporotrichosis: Clinical and Laboratory Investigation[J].The Chinese Journal of Dermatovenereology,2018,(06):672.[doi:10.13735/j.cjdv.1001-7089.201706098]

更新日期/Last Update: 2020-06-05