[1]江阳,王禹毅,张洁,等.2016年重庆地区化妆品不良反应临床特征分析[J].中国皮肤性病学杂志,2020,(02):200-204.[doi:10.13735/j.cjdv.1001-7089.201901144]
　JIANG Yang,WANG Yuyi,ZHANG Jie,et al.Clinical Characteristics of Adverse Reactions to Cosmetic Products in Chongqing in 2016[J].The Chinese Journal of Dermatovenereology,2020,(02):200-204.[doi:10.13735/j.cjdv.1001-7089.201901144]
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2016年重庆地区化妆品不良反应临床特征分析
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2020年02期
页码:
200-204
栏目:
调查报告
出版日期:
2020-02-01

文章信息/Info

Title:
Clinical Characteristics of Adverse Reactions to Cosmetic Products in Chongqing in 2016
文章编号:
1001-7089(2020)02-0200-05
作者:
江阳; 王禹毅; 张洁; 李德如; 邓抒琴; 刁庆春; 朱瑾瑜; 宁春竹; 吕静
重庆市第一人民医院,重庆市中医院道门口院部皮肤科,重庆 400011
Author(s):
JIANG Yang; WANG Yuyi; ZHANG Jie; LI Deru; DENG Shuqin; DIAO Qingchun; ZHU Jinyu; NING Chunzhu; LYU Jing
(Department of Dermatology,the First People's Hospital,Traditional Chinese Medicine Hospital,Chongqing 400011,China)
关键词:
化妆品;  不良反应;  斑贴试验;  临床特征
Keywords:
Cosmetics;  Adverse reactions;  Patch test;  Clinical characteristics
分类号:
R 758.22; TQ 658
DOI:
10.13735/j.cjdv.1001-7089.201901144
文献标志码:
B
摘要:
目的 分析2016年重庆地区化妆品不良反应的临床特征,掌握本市的化妆品质量安全状况,制定化妆品安全风险监管措施。方法 以2016年上传到重庆市化妆品不良反应报告系统的全市化妆品不良反应病例为调查对象(采用SPSS20软件进行统计分析)。收集患者的个人信息、病史记录、临床症状、化妆品信息及相关实验室检查结果等。 结果 2016年重庆市共上报1 860例化妆品不良反应病例,每百万人口报告数量为62例。患者女性(94.19%)明显多于男性(5.81%),年龄从1～73岁均有发生,主要集中在21～40岁(67.58%)。1.02%的患者报告有既往过敏史。化妆品不良反应的潜伏期普遍较短,超过一半的患者潜伏期在3 d以内,发生的部位主要在头面部(占比超过95%)。化妆品不良反应类型以接触性皮炎为主(81.34%),其次为化妆品痤疮(5.80%)。患者的自觉症状主要为瘙痒,其次为灼热感和紧绷感,主要皮损形态为红斑、丘疹、水肿。可疑致敏化妆品主要为护肤类(1 513例)和育发类(93例)。仅有66例患者选择进行斑贴试验(6例患者实验结果为阴性,其余均为阳性)。结论 重庆地区化妆品不良反应发生人群主要为中青年女性,多由护肤类和育发类所致,临床以化妆品接触性皮炎发生率最高,斑贴试验仍是诊断化妆品接触性皮炎的重要检查手段。
Abstract:
Objective To analyse the clinical characteristics of adverse reactions to cosmetic products in Chongqing in 2016,to pinpoint the quality and safety of cosmetics in this city,and to formulate regulatory measures to address safety risks of cosmetics.Methods Patient data were retrieved from the cosmetic adverse reaction reporting system of Chongqing,and the personal information,medical records,clinical characteristics and the cosmetic information as well as laboratory results were collected.Results There were 1 860 reported cases with adverse reactions to cosmetic products in 2016,and 62 out of million people were reported with adverse reaction to cosmetic products in local population.Females(94.19%)were obviously affected more than males(5.81%).The majority patients were aged 21 to 40 years as the age of patients ranged from 1 year to 73.Among these patients,1.02% had history of allergy and half of them had a latent period of less than three days.Head and face were the most affected body parts and the major types of adverse reactions to cosmetic products were contact dermatitis(81.34%)and cosmetic acne(5.80%).The most common symptoms involved were pruritus,burning sensation and tightness of the skin, and the common skin lesions included erythema,papula and edema.Suspected cosmetics were mostly from skin care products(1 513 cases, and the common)and hair care products(93 cases).Only 66 patients accepted patch tests,6 cases had negative results and others were all tested positive.Conclusion Adverse drug reactions affect young and middle-aged women mostly,and skin care products as well as hair care products are the most risk factors.Contact dermatitis is the hightest adeverse reaction to cosmetic products and the patch test is still the most effective method in helping diagnosing contact dermatitis to cosmetic products.

参考文献/References:

[1] 中华人民共和国卫生部.GB17149.1-1-1997化妆品皮肤不良反应诊断标准及处理原则[S].北京:中国标准出版社,1997.
[2] 中华人民共和国卫生部.GB17149.1-1997化妆品皮肤皮肤病诊断标准及处理原则总则[S].北京:中国标准出版社,1997.
[3] 刘玮,房军,蔡瑞康.化妆品不良反应及其临床监测[J].中国卫生监督杂志,2008,15(3):183-185.
[4] 杨森.化妆品皮肤不良反应诊疗指南[J].中华皮肤科杂志,2018,11(51):783-786.
[5] Alani JI,Davis MD,Yiannias JA.Allergy to cosmetics:a literature review[J].Dermatitis,2013,24(6):283-290.
[6] 谢淑霞,赖维,万苗坚,等.383例化妆品皮肤不良反应临床分析[J].临床皮肤科杂志,2005,34(7):442.
[7] 钟益萍,苏亮,陈勇军,等2016年广州地区913例化妆品不良反应回归性分析[J].皮肤性病诊疗学杂志,2017,24(4):261-263.
[8] Kohl L,Blondeel A,Song M.Allergic contact dermattis from cosmetics.Retrospective analysis of 819 patch-tested patients[J].Dermatology,2002,204(4):334-337.

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备注/Memo

备注/Memo:
[基金项目] 2016重庆市化妆品不良反应监测研究资助项目
[作者单位] 重庆市第一人民医院,重庆市中医院道门口院部皮肤科,重庆 400011
[通信作者] 吕静,E-mail:16560646@qq.com
[网络首发时间] 2019-12-11 10:32[网络首发地址] https://doi.org/10.13735/j.cjdv.1001-7089.201901144[Corresponding author] LYU Jing,E-mail:16560646@qq.com
更新日期/Last Update: 2020-02-28