[1]刘爱民,张步鑫,宋坤,等.麻防犀角地黄汤干预寻常性银屑病寒包火证的疗效及作用机制[J].中国皮肤性病学杂志,2019,(10):1194-1197.[doi:10.13735/j.cjdv.1001-7089.201810005]
 LIU Aimin,ZHANG Buxin,SONG Kun,et al.Efficacy of Mafang Xijiao Dihuang Decoction for Psoriasis Vulgaris with Cold Enveloping Fire Syndrome and the Underlying Mechanisms[J].The Chinese Journal of Dermatovenereology,2019,(10):1194-1197.[doi:10.13735/j.cjdv.1001-7089.201810005]
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麻防犀角地黄汤干预寻常性银屑病寒包火证的疗效及作用机制
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年10期
页码:
1194-1197
栏目:
中医中药
出版日期:
2019-09-13

文章信息/Info

Title:
Efficacy of Mafang Xijiao Dihuang Decoction for Psoriasis Vulgaris with Cold Enveloping Fire Syndrome and the Underlying Mechanisms
文章编号:
1001-7089(2019)10-1194-04
作者:
刘爱民1张步鑫2宋坤2吴盘红1徐胜东2
1.河南省中医院皮肤科,河南中医药大学皮肤性病研究所,河南 郑州450002; 2.河南中医药大学,河南 郑州450046
Author(s):
LIU Aimin1ZHANG Buxin2SONG Kun2WU Panhong1XU Shengdong2
(1.Department of Dermatology,Henan Traditional Chinese Medicine Hospital; Institute of Dermatology and Venereology of Henan Traditional Chinese Medicine College,Zhengzhou 450002,China; 2.Henan University of Chinese Medicine,Zhengzhou 450002,China)
关键词:
银屑病 寒包火 麻防犀角地黄汤 白细胞介素-17 血管内皮生长因子
Keywords:
Psoriasis Winter psoriasis vulgaris with cold enveloping fire syndrome Ma Fang Xijiao Dihuang decoction Interleukin-17 Vascular endothelial growth factor
分类号:
R 758.63
DOI:
10.13735/j.cjdv.1001-7089.201810005
文献标志码:
B
摘要:
目的 临床观察麻防犀角地黄汤治疗冬季银屑病寒包火证的疗效并探讨其作用机制。方法 将确诊为冬季寒包火证的患者90例,随机分为治疗组、对照组A和对照组B,每组各30例。治疗组口服麻防犀角地黄汤加减,对照组A口服犀角地黄汤,对照组B口服阿维A胶囊,三组均同法外用卡泊三醇软膏,治疗8周后判断疗效并检测IL-17和VEGF的变化。结果 治疗组显效率90.00%(27/30)优于对照组A 40.00%(12/30)和对照组B 46.67%(14/30)(P<0.05); 治疗组PASI积分下降程度优于对照组A(P<0.05)和对照组B(P<0.05); 治疗前3组患者的IL-17和VEGF值之间差异无统计学意义(P>0.05),治疗组和对照组B治疗前后IL-17差异均有统计学意义(P<0.05),且治疗后两组IL-17差异无统计学意义(P>0.05); 3组治疗前后的VEGF差异均有统计学意义(P<0.05),治疗后治疗组VEGF水平低于两个对照组,且差异均有统计学意义(P<0.05)。结论 麻防犀角地黄汤对寻常性银屑病寒包火证疗效显著,其机制可能与下调IL-17和VEGF水平有关。
Abstract:
Objective To evaluate the efficacy of Ma Fang Xijiao Dihuang Decoction for psoriasis vulgaris with cold enveloping fire syndrome in winter, and to explore its underlying mechanisms.Methods Ninety patients with psoriasis vulgaris with cold enveloping fire syndrome in winter were randomly divided into treatment group,control groups A and B(30 cases/group).The treatment group was treated with Ma Fang Xijiao Dihuang decoction,while the control groups A and B were treated with Xijiao Dihuang decoction,and Acitretin capsule,respectively.All three groups were also treated with calcipotriol ointment.After 8-week treatments,efficacy and changes in IL-17 and VEGF levels were assessed.Results The effective rates were significant higher in the treatment group(90.00%,27/30)than in either control groups(group A:40.00%,12/30; group B:66.67%,14/30; P<0.05 for both controls vs.treatment group).Similarly,reductions in PASI scores were more significant in the treatment group than in the controls(P<0.05 for both groups A and B vs.treatment group).Expression levels of IL-17 and VEGF did not differ significantly among three groups before the treatment(P>0.05).However,treatments changed IL-17 levels significantly in both the treatment group and control group B(P<0.05 vs.pretreatment)although IL-17 levels did not differ between these two groups after treatment.Moreover,all three treatments altered VEGF levels significantly(P<0.05 vs.pretreatment).In addition,VEGF levels were significantly lower in the treatment group than in the controls(P<0.05 for treated group vs.controls).Conclusion Ma Fang Xijiao Dihuang decoction is effective for psoriasis vulgaris with cold enveloping fire syndrome,possibly via down-regulation of IL-17 and VEGF expression.

参考文献/References:

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备注/Memo

备注/Memo:
[基金项目] 河南省科技计划(162102310181)
[作者单位] 1.河南省中医院皮肤科,河南中医药大学皮肤性病研究所,河南 郑州450002; 2.河南中医药大学,河南 郑州450046
更新日期/Last Update: 2019-09-12