[1]刘倩,申小平,陆洪光.类风湿性嗜中性皮炎1例[J].中国皮肤性病学杂志,2019,(10):1180-1182.[doi:10.13735/j.cjdv.1001-7089.201807019]
 LIU Qian,SHEN Xiaoping,LU Hongguang.A Case of Rheumatoid Neutrophilic Dermatitis[J].The Chinese Journal of Dermatovenereology,2019,(10):1180-1182.[doi:10.13735/j.cjdv.1001-7089.201807019]
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类风湿性嗜中性皮炎1例
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年10期
页码:
1180-1182
栏目:
病例报告
出版日期:
2019-09-13

文章信息/Info

Title:
A Case of Rheumatoid Neutrophilic Dermatitis
文章编号:
1001-7089(2019)10-1180-03
作者:
刘倩12申小平2陆洪光2
1.贵州医科大学,贵州 贵阳 550004; 2.贵州医科大学附属医院皮肤科,贵州 贵阳 550004
Author(s):
LIU Qian12SHEN Xiaoping2LU Hongguang2
(1.Guizhou Medical University,Guiyang 550004,China; 2.Department of Dermatology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)
关键词:
类风湿性嗜中性皮炎 类风湿关节炎
Keywords:
Rheumatoid neutrophilic dermatitis Rheumatoid arthritis
分类号:
R 593.22
DOI:
10.13735/j.cjdv.1001-7089.201807019
文献标志码:
B
摘要:
患者女,31岁,反复全身红斑、丘疹、结节伴瘙痒2年。类风湿因子测定为60.70 IU/mL,抗环瓜氨酸肽抗体115.39 RU/mL; 皮损组织病理示:表皮呈银屑病样增生,真皮浅层及深层血管周围炎,浸润的炎症细胞以嗜中性粒细胞、淋巴细胞及浆细胞为主,脂肪小叶周围见较多嗜中性粒细胞及少量淋巴细胞、浆细胞浸润,伴大片胶原变性、红染。诊断:类风湿性嗜中性皮炎。
Abstract:
A 31-year-old female presented pruritus,erythemas,papules and nodules all over the body for two years.Levels of rheumatoid factor and anti-cyclic citrullinated peptide antibody were 60.70 IU/mL and 115.39 RU/mL,respectively.Histological examination of the skin lesion showed psoriatic hyperplasia in the epidermis,perivascular infiltrates of predominantly neutrophils,lymphocytes,and plasma cells in the superficial and deep dermis.In addition to collagen degeneration and positive for eosin staining,abundant neutrophils,a few lymphocytes and plasma cells were also observed around fat lobules.The diagnosis of rheumatoid neutrophilic dermatitis was made.

参考文献/References:

[1] 赵辨.中国临床皮肤病学[M].2版.南京:江苏凤凰科学技术出版社,2017:898-900.
[2] Ackerman AB.Histologic diagnosis of inflammatory skin diseases:a method of pattern analysis[M].Philadelphia:Lea & Febiger,1978:449-451.
[3] Lazarov A,Mor A,Cordoba M,et al.Rheumatoid neutrophilic dermatitis:an initial dermatological manifestation of seronegative rheumatoid arthritis[J].J Euro Acad Dermatol Venereol,2002,16(1):74-76.
[4] 杨光艳,邢建军,黄茜,等.表现为匍行性回状红斑的类风湿性嗜中性皮炎1例[J].中国皮肤性病学杂志,2010,24(5):462-463.
[5] Lu CI,Yang CH,Hong HS.A bullous neutrophilic dermatosis in a patient with severe rheumatoid arthritis and monoclonal IgA gammopathy[J].J Am Acad Dermatol,2004,51(2 Suppl):S94-S96.
[6] Fujio Y,Funakoshi T,Nakayama K,et al.Rheumatoid neutrophilic dermatosis with tense blister formation:a case report and review of the literature[J].Australas J Dermatol,2014,55(1):e12-e14

备注/Memo

备注/Memo:
[作者单位] 1.贵州医科大学,贵州 贵阳 550004; 2.贵州医科大学附属医院皮肤科,贵州 贵阳 550004
[通讯作者] 陆洪光,E-mail:hongguanglu@hotmail.com
更新日期/Last Update: 2019-09-12