[1]李博,黄敏,周晓鸿.多菌型麻风伴Ⅱ型麻风反应1例[J].中国皮肤性病学杂志,2019,(10):1177-1179.[doi:10.13735/j.cjdv.1001-7089.201810063]
 LI Bo,HUANG Min,ZHOU Xiaohon.A Case of Multibacillary Leprosy with Type Ⅱ Leprosy Reaction[J].The Chinese Journal of Dermatovenereology,2019,(10):1177-1179.[doi:10.13735/j.cjdv.1001-7089.201810063]
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多菌型麻风伴Ⅱ型麻风反应1例
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年10期
页码:
1177-1179
栏目:
病例报告
出版日期:
2019-09-13

文章信息/Info

Title:
A Case of Multibacillary Leprosy with Type Ⅱ Leprosy Reaction
文章编号:
1001-7089(2019)10-1177-03
作者:
李博黄敏周晓鸿
昆明医科大学第二附属医院皮肤科,云南 昆明 650101
Author(s):
LI BoHUANG MinZHOU Xiaohon
(Department of Dermatology,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)
关键词:
多菌型麻风 Ⅱ型麻风反应
Keywords:
Multibacillary leprosy Type Ⅱ leprosy reaction
分类号:
R 755.2
DOI:
10.13735/j.cjdv.1001-7089.201810063
文献标志码:
B
摘要:
患者女,25岁,双眉脱落,面、臀部、四肢浸润红斑、紫癜、血疱、疼痛4 d。皮肤科情况:双眉、睫毛、体毛脱落,爪形手,面、臀部、四肢远端皮肤见散在浸润性坏死性红斑和紫癜,部分皮损上可见血疱、破溃形成糜烂面。皮损组织病理示:表皮坏死,其下可见大疱,疱内见大量红细胞,真皮内血管及周围纤维素样坏死,周围见中性粒细胞浸润、核碎裂、管外红细胞,真皮内可见泡沫细胞肉芽肿; 抗酸染色分枝杆菌阳性。BI=4.0。诊断为界线类偏瘤型麻风伴Lucio现象。
Abstract:
A 25-year-old female presented the loss of eyebrows along with infiltrated erythemas,purpura,blood blister and pain on the face,buttocks and limbs for 4 days.The skin lesions manifested as scattered infiltrative necrotic erythema and purpura with blood blisters on the face,buttocks and extremities,along with loss of eyebrows,eyelashes and body hair,and claw hand.Skin biopsies showed epidermal necrosis and blisters,which contained large number of erythrocytes. Changes in the dermis included vascular and fibrinoid necrosis,perivascular infiltrate of neutrophils with nuclear debris,extravascular erythrocytes,and foam cell granuloma.Acid fast staining was positive for mycobacterium.Bacteriological index was 4.0.The diagnosis was borderline lepromatous leprosy with Lucio phenomenon.

参考文献/References:

[1] 赵辨.中国临床皮肤病学[M].江苏:凤凰科学技术出版社,2017:493-1011.
[2] Ranugha P,Chandrashekar L,Kumari R,et al.Is it Lucio phenomenon or necrotic erythema nodosum leprosum[J].Indian J Dermatol,2013,58(2):160.
[3] Ramal C,Casapia M,Marin J,et al.Diffuse multibacillary leprosy of lucio and latapí with Lucio's phenomenon,peru[J].Emerg Infect Dis,2017,23(11):1929-1930.
[4] Jurado F,Rodriguez O,Novales J,et al.Lucio's leprosy:a clinical and therapeutic challenge[J].Clin Dermatol,2015,33(1):66-78.
[5] 刘伟军,杨春华,王小兵,等.Ⅱ型麻风反应1例[J].中国皮肤性病学杂志,2016,30(10):1091.
[6] 刘勤思,吕小岩,刘宏杰.界线类偏瘤型麻风伴Ⅱ型麻风反应1例[J].中国皮肤性病学杂志,2015,29(11):1180-1183.

相似文献/References:

[1]王琦,王佳曼,彭晓明,等.瘤型麻风合并Ⅱ型麻风反应3例[J].中国皮肤性病学杂志,2013,(11):1156.
 WANG Qi,WANG Jia-man,PENG Xiao-ming,et al.Three Cases of Lepromatous Leprosy with TypeⅡ Leprosy Reaction[J].The Chinese Journal of Dermatovenereology,2013,(10):1156.

备注/Memo

备注/Memo:
[作者单位] 昆明医科大学第二附属医院皮肤科,云南 昆明 650101
[通讯作者] 周晓鸿,E-mail:xiaohongzhou @126.com
更新日期/Last Update: 2019-09-12