[1]许美凤,刘艳,李晓莉,等.C1QTNF6基因遗传多态性与中国汉族人群的白癜风易感风险相关性[J].中国皮肤性病学杂志,2019,(10):1110-1115.[doi:10.13735/j.cjdv.1001-7089.201903101]
 XU Meifeng,LIU Yan,LI Xiaoli,et al.Association of Genetic Polymorphism of C1QTNF6 and Vitiligo Susceptibility Risk in Chinese Han Population[J].The Chinese Journal of Dermatovenereology,2019,(10):1110-1115.[doi:10.13735/j.cjdv.1001-7089.201903101]
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C1QTNF6基因遗传多态性与中国汉族人群的白癜风易感风险相关性
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年10期
页码:
1110-1115
栏目:
论著
出版日期:
2019-09-13

文章信息/Info

Title:
Association of Genetic Polymorphism of C1QTNF6 and Vitiligo Susceptibility Risk in Chinese Han Population
文章编号:
1001-7089(2019)10-1110-06
作者:
许美凤1刘艳1李晓莉1马慧群1王梅1刘亚乐1董炜2肖生祥1
1. 西安交通大学第二附属医院皮肤病院, 陕西 西安 710004; 2. 西安交通大学第二附属医院检验科, 陕西 西安 710004
Author(s):
XU Meifeng1LIU Yan1LI Xiaoli1MA Huiqun1WANG Mei1LIU Yale1DONG Wei2XIAO Shengxiang1
(1.Department of Dermatology,the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China; 2.Department of Clinical Laboratory,the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China)
关键词:
C1QTNF6基因 白癜风 单核苷酸多态性 疾病易感性 中国汉族人群
Keywords:
Gene C1QTNF6 Vitiligo Single nucleotide polymorphisms Association analyses Han Chinese
分类号:
R 758.4+1
DOI:
10.13735/j.cjdv.1001-7089.201903101
文献标志码:
A
摘要:
目的 研究中国汉族人群中C1QTNF6基因多态性与白癜风易感性之间的潜在关联。 方法 将所选择的C1QTNF6基因内14个标签单核苷酸多态性(SNP)在1 148例个体(白癜风患者326例,健康对照822例)中进行基因分型。为每个标签SNP使用Logistic模型以评估它们对白癜风风险的潜在贡献。使用基于单位点和单倍型的方法进行遗传关联分析。 结果 SNP rs229527在Bonferroni校正后依然具有与白癜风风险显著关联的信号(以年龄和性别校正后的等位基因P= 0.000 6)。rs229527的T等位基因是白癜风的风险等位基因,并且可能是导致白癜风风险增加的诱发因素(以年龄和性别校正后的OR = 1.58,95%CI=1.22~2.05)。单倍型分析也获得了与单位点分析相类似的结果。结论 C1QTNF6基因与中国汉族人群白癜风的遗传易感性密切相关,也进一步证明了C1QTNF6基因参与了白癜风的发生和发展。
Abstract:
Objective To investigate the potential association between genetic polymorphism of C1QTNF6 gene and vitiligo susceptibility in Han Chinese population.Methods Fourteen selected tag SNPs in C1QTNF6 gene were genotyped in 1 148 subjects, including 326 vitiligo patients and 822 healthy controls.Logistic models were fitted to estimate potential contribution of each SNP to the risk of vitiligo.Genetic association analyses were performed in both single-marker and haplotype-based methods.Results The SNP rs229527 was found to capture a significant association signal with the risk of vitiligo after a Bonferroni Correction(adjusted allelic P values with age and gender=0.000 6).Moreover,overall analyses indicated that the T allele of rs229527 was a risk allele of vitiligo,possibly a predisposing factor for the development of vitiligo(adjusted OR with age and gender=1.58,95%CI=1.22~2.05).The results of the haplotype analyses were similar to that of the single-SNP analyses.Conclusion C1QTNF6 is closely associated with the genetic susceptibility of vitiligo in the Han Chinese population,which further demonstrates that gene C1QTNF6 is involved in the onset and the development of vitiligo.

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备注/Memo

备注/Memo:
[基金项目] 陕西省重点研发计划一般项目(2018SF-008)
[作者单位] 1. 西安交通大学第二附属医院皮肤病院, 陕西 西安 710004; 2. 西安交通大学第二附属医院检验科, 陕西 西安 710004
[通讯作者] 肖生祥,E-mail:xiao_sx@163.com
更新日期/Last Update: 2019-09-12