[1]侯明慧,刘升云.临床无肌病性皮肌炎与皮肌炎临床差异的探究[J].中国皮肤性病学杂志,2019,(08):895-898.[doi:10.13735/j.cjdv.1001-7089.201809170]
 HOU Minghui,LIU Shengyun.The Clinical Differences Between Amyopathic Dermatomyositis and Typical Dermatomyositis[J].The Chinese Journal of Dermatovenereology,2019,(08):895-898.[doi:10.13735/j.cjdv.1001-7089.201809170]
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临床无肌病性皮肌炎与皮肌炎临床差异的探究
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年08期
页码:
895-898
栏目:
临床经验
出版日期:
2019-07-15

文章信息/Info

Title:
The Clinical Differences Between Amyopathic Dermatomyositis and Typical Dermatomyositis
文章编号:
1001-7089(2019)08-0985-04
作者:
侯明慧刘升云
郑州大学第一附属医院风湿免疫科,河南 郑州 450001
Author(s):
HOU MinghuiLIU Shengyun
(Department of Rheumatology and Immunology,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450001,China)
关键词:
无肌病性皮肌炎 皮肌炎 肺间质病变 血脂异常
Keywords:
Amyopathy dermatomyositis Dermatomyositis Interstitial lung disease Dyslipidemia
分类号:
R 593.26
DOI:
10.13735/j.cjdv.1001-7089.201809170
文献标志码:
B
摘要:
目的 通过对本研究中临床无肌病性皮肌炎(CADM)及皮肌炎(DM)的回顾性对比分析,加深对CADM与DM各方面差别的了解。方法 回顾性研究郑州大学第一附属医院2014年1月1日-2016年1月1日期间入院治疗的111例皮肌炎患者,对30例CADM及81例DM患者进行对比分析。结果 CADM组合并肺间质病变和关节炎的比例显著高于DM组,在发病年龄、始发症状、血脂水平等方面两组间差异有统计学意义(P<0.05); 而在抗核抗体谱、ESR、CRP水平方面两组间差异无统计学意义; 两组在糖皮质激素用量方面差异无统计学意义。结论 CADM较DM有更高的肺间质病变、关节炎及恶性肿瘤的发生率,DM有更高的血脂异常的发生率。
Abstract:
Objective To deepen the understanding of the differences between amyopathic dermatomyositis(CADM)and typical dermatomyositis(DM)through retrospective comparative analysis.Methods A retrospective study was performed on 111 patients with dermatomyositis admitted to the First Affiliated Hospital of Zhengzhou University from January 1st,2014,to January 1st,2016.We compared 30 patients with CADM and 81 patients with DM.Results The proportion of CADM combined with interstitial lung disease(ILD)and arthritis was significantly higher than that of the DM group.There were significant differences in age of onset,initial symptoms,and lipid levels between the two groups(P<0.05).There were no significant differences in ANA,ESR and CRP levels,and amount of glucocorticoid between the two groups.Conclusion CADM has a higher incidence of ILD and arthritis than DM,and DM has a higher prevalence of dyslipidemia.

参考文献/References:

[1] Sontheimer RD.Dermatomyositis:an overview of recent progress with emphasis on dermatologic aspects[J].Dermatol Clin,2002,20(3):387-408.
[2] Tymms KE,Webb J.Dermatomyositis and other connective tissue diseases:a review of 105 cases[J].J Rheumatol,1985,12(6):1140.
[3] Bendewald MJ,Wetter DA,Li X,et al.Incidence of dermatomyositis and clinically amyopathic dermatomyositis:a population-based study in Olmsted County,Minnesota[J].Arch Dermatol,2010,146(1):26-30.
[4] Gono T,Kawaguchi Y,Hara M,et al.Increased ferritin predicts development and severity of acute interstitial lung disease as a complication of dermatomyositis[J].Rheumatology,2010,49(7):1354-1360.
[5] Nara M,Komatsuda A,Omokawa A,et al.Serum interleukin 6 levels as a useful prognostic predictor of clinically amyopathic dermatomyositis with rapidly progressive interstitial lung disease[J].Mod Rheumatol,2014,24(4):633-636.
[6] Hazuki Y,Takaharu I,Yasuhito H,et al.Clinically amyopathic dermatomyositis with rapidly progressive interstitial pneumonia:The relation between the disease activity and the serum interleukin-6 level[J].J Dermatol,2017,44(10):1164-1167.
[7] Chen M,Quan C,Diao L,et al.Measurement of cytokines,chemokines and association with clinical severity of DM/CADM disease[J].Br J Dermotal,2018,179(6):1334-1341.
[8] Xu Y,Yang CS,Li YJ,et al.Predictive factors of rapidly progressiveinterstitial lung disease in patients with clinically amyopathic dermatomyositis[J].Clin Rheumatol,2016,35(1):113-116.
[9] Huemer C,Kitson H,Malleson PN,et al.Lipodystrophy in patients with juvenile dermatomyositiseevaluation of clinical and metabolic abnormalities[J].J Rheumatol,2001,28(3):610-615.
[10] Lee LA,Hobbs KF.Lipodystrophy and metabolic abnormalities in a case of adult dermatomyositis[J].J Am Acad Dermatol,2007,57(5 Suppl):S85-87.

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备注/Memo

备注/Memo:
[作者单位] 郑州大学第一附属医院风湿免疫科,河南 郑州 450001
更新日期/Last Update: 2019-07-15