[1]吕超,胡小平,于波,等.瘤型麻风误诊1例分析[J].中国皮肤性病学杂志,2019,(07):851-853.[doi:10.13735/j.cjdv.1001-7089.201806013]
 LYU Chao,HU Xiaoping,YU Bo,et al.Analysis of a Case of Misdiagnosed Lepromatous Leprosy[J].The Chinese Journal of Dermatovenereology,2019,(07):851-853.[doi:10.13735/j.cjdv.1001-7089.201806013]
点击复制

瘤型麻风误诊1例分析
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年07期
页码:
851-853
栏目:
误诊教训
出版日期:
2019-06-16

文章信息/Info

Title:
Analysis of a Case of Misdiagnosed Lepromatous Leprosy
文章编号:
1001-7089(2019)07-0851-03
作者:
吕超1胡小平2于波2叶庭路2
1.安徽医科大学北京大学深圳医院临床学院皮肤科,广东 深圳 518000; 2.北京大学深圳医院皮肤科,广东 深圳 518000
Author(s):
LYU Chao1HU Xiaoping2YU Bo2YE Tinglu2
(1.Department of Dermatology,Clinical Institute of Peking University Shenzhen Hospital,Anhui Medical University,Shenzhen 518000,China; 2.Department of Dermatology,Clinical Institute of Peking University Shenzhen Hospital,Shenzhen 518000,China)
关键词:
瘤型麻风 麻风 过敏 荨麻疹
Keywords:
Lepromatous leprosy(LL) Leprosy Allergy Urticaria
分类号:
R 755.2
DOI:
10.13735/j.cjdv.1001-7089.201806013
文献标志码:
B
摘要:
患者男,38岁。全身反复出现暗红斑3年,伴眉毛脱落、面部数个黄豆大肤色结节3个月余。多次予以抗过敏治疗,红斑可暂时减少,但反复发作。皮损组织病理示:真皮层见大量组织细胞,巢团状,弥漫分布,淋巴细胞少见,组织细胞胞浆空泡状,内见细短杆状的可疑微生物样结构; 抗酸染色检查(+)。皮肤组织液查菌结果(2+~5+)。细菌密度指数(BI)4.2。诊断:瘤型麻风。
Abstract:
A 38-year-old male presented with recurrent erythema all over the body for three years.He had partial eyebrow hair loss and several soybean-sized nodules on his face for more than three months.After repeated anti-allergy treatment,erythema was temporarily reduced,however,there was repeated attack.Histopathology showed that abundant histocytes in the dermis with nest-like structure,which were diffusely distributed.In addition,lymphocytes were rare,and intracytoplasmic vacuoles were seen in histocytes,with suspicious short-rod-shaped microbial structure.Acid-fast staining assay showed positive results.The result of bacteria detection of skin tissue fluid was 2+ ~ 5+.The bacterial density index(BI)was 4.2.The final diagnosis was lepromatous leprosy(LL).

参考文献/References:

[1] 王景权,侯启年,潘春枝,等.我国麻风病例发现策略的探讨[J].中国公共卫生管理,2012,28(1):23-25.
[2] Gupta SK,Kaur S, Malhotra V,et al.Lepromatous leprosy:An unusual presentation[J].Indian J Lepr,2015,87(1):27-32.
[3] Zeng XZ,Wang YN,Wang JS,et al.A case of lepromatous leprosy complicated by hemop- hagocytosis misdiagnosed as hemophagocytic lymphohistiocytosis[J].Int J Infect Dis,2014,23:28-30.
[4] 龙福泉,蒙秉新,陈浩,等.Ⅱ型麻风反应误诊并死亡1例[J].中国皮肤性病学杂志,2011,25(4):318-319.
[5] 时淑舫,刘金香,周晓鸽,等.麻风病临床及病理特点[J].临床和实验医学杂志,2011,10(24):1891-1893.
[6] Alvarado-Navarro A,Montoya-Buelna M,Muñoz-Valle JF,et al.The 3'UTR 1188 A/C polymorphism in the interleukin-12p40 gene(IL-12B)is associated with lepromatous leprosy in the west of Mexico[J]. Immunol Lett,2008,118(2):148-151.
[7] Brochado MJ,Gatti MF,Zago MA,et al.Association of the solute carrier family 11 member 1 gene polymorphisms with susceptibility to leprosy in a Brazilian sample[J].Mem Inst Oswaldo Cruz,2016,111(2):101-105.
[8] Zhang FR,Liu H,Irwanto A,et al.HLA-B*13:01 and the dapsone hypersensitivity syndrome[J].N Engl J Med,2013,369(17):1620-1628.

相似文献/References:

[1]樊俊威,吕金,张丽娟,等.界限类偏瘤型麻风误诊为银屑病1例[J].中国皮肤性病学杂志,2017,(01):102.[doi:10.13735/j.cjdv.1001-7089.201601075]
 FAN jun-wei,LV Jin,ZHANG Li-juan,et al.A case of Borderline Lepromatous Leprosy Misdiagnosed as Psoriasis[J].The Chinese Journal of Dermatovenereology,2017,(07):102.[doi:10.13735/j.cjdv.1001-7089.201601075]
[2]尚盼盼,糜自豪,曹静,等.ALDH2基因和其他脂质代谢基因在麻风患者外周血中的表达[J].中国皮肤性病学杂志,2017,(07):735.[doi:10.13735/j.cjdv.1001-7089.201610116]
 SHANG Pan-pan,MI Zi-hao,CAO Jing,et al.The Expressions of Gene Aldehyde Dehydrogenase 2 and Lipid Metabolism Genes in Leprosy[J].The Chinese Journal of Dermatovenereology,2017,(07):735.[doi:10.13735/j.cjdv.1001-7089.201610116]
[3]张刚,杨钢,张金玲,等.艾滋病免疫重建炎性综合征并发麻风1例并文献复习[J].中国皮肤性病学杂志,2017,(10):1102.[doi:10.13735/j.cjdv.1001-7089.201703154]
 ZHANG Gang,YANG Gang,ZHANG Jin-ling,et al.Case Report and Review of AIDS IRIS with Leprosy[J].The Chinese Journal of Dermatovenereology,2017,(07):1102.[doi:10.13735/j.cjdv.1001-7089.201703154]

备注/Memo

备注/Memo:
[基金项目] 深圳市三名工程项目资助(SZSM 201812059)
[作者单位] 1.安徽医科大学北京大学深圳医院临床学院皮肤科,广东 深圳 518000; 2.北京大学深圳医院皮肤科,广东 深圳 518000
[通讯作者] 胡小平,E-mail:47776040@qq.com
[Corresponding author] HU Xiaoping,E-mail:47776040@qq.com
更新日期/Last Update: 2019-06-15