[1]谭强,肖敏,余倩颖,等.四川文氏皮外科协定方马齿苋汤加减治疗慢性湿疹疗效及对IL-4、IL-22、IFN-γ的影响[J].中国皮肤性病学杂志,2019,(07):824-827.[doi:10.13735/j.cjdv.1001-7089.201811199]
 TAN Qiang,XIAO Min,YU Qianying,et al.Therapeutic Effects of Sichuan Wen's Dermatological Cipher Prescription Modified Machixian Decoction on Chronic Eczema and Its Effects on IL-4,IL-22 and IFN-γ[J].The Chinese Journal of Dermatovenereology,2019,(07):824-827.[doi:10.13735/j.cjdv.1001-7089.201811199]
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四川文氏皮外科协定方马齿苋汤加减治疗慢性湿疹疗效及对IL-4、IL-22、IFN-γ的影响
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年07期
页码:
824-827
栏目:
中医中药
出版日期:
2019-06-16

文章信息/Info

Title:
Therapeutic Effects of Sichuan Wen's Dermatological Cipher Prescription Modified Machixian Decoction on Chronic Eczema and Its Effects on IL-4,IL-22 and IFN-γ
文章编号:
1001-7089(2019)07-0824-04
作者:
谭强12 肖敏3余倩颖3尤雯丽4雷晴3陈明岭3艾儒棣3
1.成都中医药大学,四川 成都 610075; 2.第四军医大学西京皮肤医院,陕西 西安 710032; 3.成都中医药大学附属医院,四川 成都 610075; 4.青岛大学附属医院,山东 青岛 266003
Author(s):
TAN Qiang12XIAO Min3YU Qianying3YOU Wenli4LEI Qing3CHEN Mingling3AI Rudi3
(1.Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China; 2.Department of Dermatology,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,China; 3.Hospital Affiliated to Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China; 4.The Affiliated Hospital of Qingdao University,Qingdao 266003,China)
关键词:
慢性湿疹 湿热蕴肤证 马齿苋汤
Keywords:
Chronic eczema Damp heat storage in skin syndrome Machixian decoction
分类号:
R 758.23
DOI:
10.13735/j.cjdv.1001-7089.201811199
文献标志码:
B
摘要:
目的 观察四川文氏皮外科协定方马齿苋汤加减对慢性湿疹(湿热蕴肤证)患者的疗效,探讨其可能的作用机制。方法 用马齿苋汤加减治疗慢性湿疹,共治疗4周,观察治疗前后EASI评分及瘙痒评分变化; 采用ELISA法检测慢性湿疹(湿热蕴肤证)患者外周血IL-4、IL-22、IFN-γ的水平,观察口服马齿苋汤加减治疗4周后对其影响。结果 治疗后患者EASI评分及瘙痒评分均明显下降,差异有统计学意义(P<0.01); 治疗后外周血IFN-γ水平升高,与治疗前比较差异无统计学意义(P>0.05),IL-4、IL-22水平下降,与治疗前比较差异有统计学意义(P<0.01)。结论 采用马齿苋汤加减治疗慢性湿疹可取得满意疗效,其可能通过下调IL-4、IL-22水平发挥治疗作用。
Abstract:
Objective To observe the efficacy of Sichuan Wen's dermatological cipher prescription modified Machixian decoction in patients with chronic eczema(damp heat storage in skin syndrome)and to investigate the potential mechanism of action.Methods Patients with chronic eczema were administered modified Machixian decoction for 4 weeks,and changes of their EASI scores and pruritus scores were observed.Peripheral blood from patients with chronic eczema(damp heat storage in skin syndrome)was determined for IL-4,IL-22 and IFN-γ expression with ELISA.Changes of the above indicators after 4 weeks of taking modified Machixian decoction were also observed.Results EASI scores and pruritus scores were significantly decreased after treatment(P<0.01).IFN-γ was increased after treatment,which did not differ significantly from that before treatment(P>0.05).IL-4 and IL-22 were significantly decreased after treatment(P<0.01).Conclusion Modified Machixian decoction have a good effect on chronic eczema(damp heat storage in skin syndrome),which may have a therapeutic effect by down-regulating IL-4 and IL-22.

参考文献/References:

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备注/Memo

备注/Memo:
[基金项目] 四川省中医药管理局科研重点项目(2016Z004)
[作者单位] 1.成都中医药大学,四川 成都 610075; 2.第四军医大学西京皮肤医院,陕西 西安 710032; 3.成都中医药大学附属医院,四川 成都 610075; 4.青岛大学附属医院,山东 青岛 266003
[通讯作者] 陈明岭,E-mail:cmlll388@sina.com
[Corresponding author] CHEN Mingling,E-mail:cmlll388@sin
更新日期/Last Update: 2019-06-15