[1]赖玮婧,江玉波,王少清.下肢钙化防御1例并文献复习[J].中国皮肤性病学杂志,2019,(07):811-813.[doi:10.13735/j.cjdv.1001-7089.201807156]
 LAI Weijing,JIANG Yubo,WANG Shaoqing.A Case of Calciphylaxis in the Lower Extremities and Literature Review[J].The Chinese Journal of Dermatovenereology,2019,(07):811-813.[doi:10.13735/j.cjdv.1001-7089.201807156]
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下肢钙化防御1例并文献复习
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年07期
页码:
811-813
栏目:
病例报告
出版日期:
2019-06-16

文章信息/Info

Title:
A Case of Calciphylaxis in the Lower Extremities and Literature Review
文章编号:
1001-7089(2019)07-0811-03
作者:
赖玮婧江玉波王少清
成都医学院第一附属医院肾病科,四川 成都 610500
Author(s):
LAI WeijingJIANG YuboWANG Shaoqing
(Department of Nephrology,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)
关键词:
血液透析 钙化防御 皮肤溃疡
Keywords:
Hemodialysis Calciphylaxis Skin ulcer
分类号:
R 692.5
DOI:
10.13735/j.cjdv.1001-7089.201807156
文献标志码:
B
摘要:
患者男,50岁,下肢远端皮肤破溃伴疼痛20余天。患者既往有慢性肾功能衰竭病史,行维持性血液透析6年,伴严重钙磷代谢紊乱。辅助检查发现腹主动脉钙化、心脏瓣膜钙化、下肢动脉钙化。诊断钙化防御后予以扩血管、抗感染、止痛、口服非含钙磷结合剂、调整透析处方及使用硫代硫酸钠等综合治疗,患者皮肤溃疡逐渐愈合。
Abstract:
A 50-year-old male presented with skin ulcers and pain in the lower extremity for more than 20 days.He had a history of chronic renal failure,and severe calcium and phosphorus metabolism disorder,and underwent maintenance hemodialysis for 6 years.Auxiliary examination found calcification of abdominal aorta,heart valves and lower limb arteries.Accordingly,diagnosis of calciphylaxis was made,which was resolved by combination therapy,including dilating blood vessel,fighting infection,relieving pain,as well as oral administration of non-calcium phosphate binder,adjustment of dialysis prescription,and intravenous infusion of sodium thiosulfate.The patient's skin ulcers gradually healed.

参考文献/References:

[1] Guldbakke KK,Khaehemoune A.Calciphylaxis[J].Int J Dermatol,2007,46(3):231-238.
[2] Allegretti AS,Nazarian RM,Goverman J,et al.Calciphylaxis:a rare but fatal delayed complication of Roux-en-Y gastric bypass surgery[J].Am J Kidney Dis,2014,64(2):274-277.
[3] Weenig R,Sewell L,Davis M,et al.Calciphylaxis:natural history,risk factor analysis,and outcome[J].J Am Acad Dermatol,2007,56(4):569-579.
[4] Selye H,Gentile G,Prioreschi P.Cutaneous molt induced by calciphylaxis in the rat[J].Science,1961,134(3493):1876-1877.
[5] Nigwekar SU,Kroshinsky D,Nazarian RM,et al.Calciphylaxis:risk factors,diagnosis,and treatment[J].Am J Kidney Dis,2015,66(1):133-146.
[6] Lin WT,Chao CM.Tumoral calcinosis in renal failure[J].Q J Med,2014,107(5):387.
[7] Jeong HS,Dominguez AR.Calciphylaxis:controversies in pathogenesis,diagnosis and treatment[J].Am J Med Sci,2016,351(2):217-227.
[8] London GM,Marty C,Marchais SJ,et al.Arterial calcifications and bone histomorphometry in end-stage renal disease[J].J Am Soc Nephrol,2004,15(7):1943-1951.
[9] Hayashi M.Calciphylaxis:diagnosis and clinical features[J].Clin Exp Nephrol,2013,17(4):498-503.
[10] Cicone JS,Petronis JB,Embert CD,et al.Successful treatment of calciphylaxis with intravenous sodium thiosulfate[J].Am J Kidney Dis,2004,43(6):1104-1108.
[11] Peng T,Zhuo L,Wang Y,et al.A systematic review of sodium thiosulfate in treating calciphylaxis in chronic kidney disease patients[J].Nephrology(Carlton),2018,23(7):669-675.
[12] Nigwekar SU,Brunelli SM,Meade D,et al.Sodium thiosulfate therapy for calcific uremic arteriolopathy[J].Clin J Am Soc Nephrol,2013,8(7):1162-1170.
[13] Nayak-Rao S.Achieving effective pain relief in patients with chronic kidney disease:a review of analgesics in renal failure[J].J Nephrol,2011,24(1):35-40.

备注/Memo

备注/Memo:
[基金项目] 四川省老年医学临床医学研究中心专项科研项目(SCLNZX201801)
[作者单位] 成都医学院第一附属医院肾病科,四川 成都 610500
[通讯作者] 王少清,E-mail:wowosasa2003@163.com
更新日期/Last Update: 2019-06-15