[1]刘琼,许贵霞,张思平.天疱疮患者感染危险因素分析[J].中国皮肤性病学杂志,2019,(07):788-791.[doi:10.13735/j.cjdv.1001-7089.201809116]
 LIU Qiong,XU Guixia,ZHANG Siping.Risk Factors for Infection in Patients with Pemphigus[J].The Chinese Journal of Dermatovenereology,2019,(07):788-791.[doi:10.13735/j.cjdv.1001-7089.201809116]
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天疱疮患者感染危险因素分析
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年07期
页码:
788-791
栏目:
临床经验
出版日期:
2019-06-16

文章信息/Info

Title:
Risk Factors for Infection in Patients with Pemphigus
文章编号:
1001-7089(2019)07-0788-04
作者:
刘琼许贵霞张思平
中国科学技术大学附属第一医院(安徽省立医院)皮肤科,安徽 合肥 230001
Author(s):
LIU QiongXU GuixiaZHANG Siping
(Department of Dermatology,the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China)
关键词:
天疱疮 感染 糖尿病 低蛋白血症 念珠菌
Keywords:
Pemphigus Infection Diabetes Hypoalbuminemia Candida
分类号:
R 758.66
DOI:
10.13735/j.cjdv.1001-7089.201809116
文献标志码:
B
摘要:
目的 探讨天疱疮患者感染的危险因素。方法 回顾性分析2012-2017年本科58例住院的天疱疮患者的临床特点、感染部位、病原体,分析可能的易感因素。结果 有39例发生感染,感染率67.24%; 单因素分析显示寻常型天疱疮、口腔受累、病情重、合并糖尿病、低蛋白血症的患者感染率更高,差异有统计学意义(P<0.05); 病情重、合并糖尿病的患者院感率也更高,差异有统计学意义(P<0.05); 单独糖皮质激素和糖皮质激素联合环磷酰胺治疗的患者感染率和院感率差异均无统计学意义(P>0.05)。多因素分析显示口腔受累(OR=12.373)、病情重(OR=11.300)、合并糖尿病(OR=17.268)、低蛋白血症(OR=8.699)是感染的独立危险因素; 病情重(OR=8.390)、合并糖尿病(OR=4.109)也是院感的独立危险因素。结论 天疱疮患者病情严重程度、合并糖尿病、低蛋白血症、口腔黏膜损害是感染的危险因素,环磷酰胺的应用没有增加感染的风险。
Abstract:
Objective To explore the risk factors for infection in patients with pemphigus.Methods Clinical characteristics,infection sites and pathogens of 58 pemphigus patients who were hospitalized in our department between 2012 and 2017 were retrospectively analyzed.Predisposing factors were also analyzed.Results Thirty-nine patients were infected and the rate of infection was 67.24%.Univariate analysis showed that patients with pemphigus vulgaris,oral involvement,severe disease,diabetes mellitus(DM)and hypoalbuminemia had higher infection rate,and the difference was significant(P<0.05).In addition,patients with severe disease and DM had higher nosocomial infection rate,and the difference was significant(P<0.05).The rates of infection and nosocomial infection between patients treated with glucocorticoid and those treated with glucocorticoid combined with cyclophosphamide were not significantly different(P>0.05).Multivariate analysis showed that oral involvement(OR=12.373),severity(OR=11.300),DM(OR=17.268)and hypoalbuminemia(OR=8.699)were independent risk factors for infection.Severity(OR=8.390)and DM(OR=4.109)were independent risk factors for nosocomial infection.Conclusion The severity of pemphigosis,DM,hypoalbuminemia and oral mucosa damage are the risk factors for infection.The application of cyclophosphamide dose not increase the risk of infection.

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备注/Memo

备注/Memo:
[作者单位] 中国科学技术大学附属第一医院(安徽省立医院)皮肤科,安徽 合肥 230001
[通讯作者] 张思平,E-mail:zh_siping@126.com
[Corresponding author] ZHANG Siping,E-mail:zh_siping@126.com
更新日期/Last Update: 2019-06-15