[1]周霖,王鸿,杨毅,等.寻常痤疮患者肠道-宿主共代谢产物分析[J].中国皮肤性病学杂志,2019,(07):761-765.[doi:DOI]10.13735/j.cjdv.1001-7089.201808109]
 ZHOU Lin,WANG Hong,YANG Yi,et al.Analysis of Gut Microbiota-host Co-metabolites in Patients with Acne Vulgaris[J].The Chinese Journal of Dermatovenereology,2019,(07):761-765.[doi:DOI]10.13735/j.cjdv.1001-7089.201808109]
点击复制

寻常痤疮患者肠道-宿主共代谢产物分析
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年07期
页码:
761-765
栏目:
论著
出版日期:
2019-06-16

文章信息/Info

Title:
Analysis of Gut Microbiota-host Co-metabolites in Patients with Acne Vulgaris
文章编号:
1001-7089(2019)07-0761-05
作者:
周霖王鸿杨毅黄书莉毛静熊霞邓永琼
西南医科大学附属医院,四川 泸州 646000
Author(s):
ZHOU LinWANG HongYANG YiHUANG ShuliMAO JingXIONG XiaDENG Yongqiong
(Department of Dermatology,the Affiliated Hospital of Southwest Medical University,Sichuan 646000,China)
关键词:
寻常痤疮 肠道代谢产物 睡眠
Keywords:
Acne vulgaris Gut metabolites Sleep quality
分类号:
R 758.73+3
DOI:
DOI]10.13735/j.cjdv.1001-7089.201808109
文献标志码:
A
摘要:
目的 分析寻常痤疮患者与健康对照肠道-宿主共代谢产物差异,为肠道菌群参与寻常痤疮发病机制的研究提供理论依据。方法 采集 43 例未经治疗的寻常痤疮患者和43例年龄、性别匹配的健康对照组的粪便标本,对入组者病程、身高、体重、睡眠质量等一般资料进行调查。采用 Agilent7890B 型气相色谱仪对 118 种代谢产物进行定量分析,非参数检验比较两组代谢产物差异。结果 寻常痤疮组与健康对照组代谢产物组成存在差异; 不同病情严重程度痤疮患者代谢产物组成差异不明显; 非参数检验分析发现24种肠道-宿主共代谢物含量在痤疮组和对照组之间存在明显的差异(P<0.05); 另外,寻常痤疮患者睡眠质量较健康对照组差异有统计学意义(P<0.05); Pearson相关性分析提示肠道代谢产物与睡眠质量呈明显负相关。结论 寻常痤疮患者与健康对照肠道-宿主共代谢产物差异明显,可能成为解释肠道菌群参与寻常痤疮发病机制的纽带。
Abstract:
Objective To analyze the differences of gut microbiota-host co-metabolites between patients with acne vulgaris and healthy controls,which could help the study of gut microbiota involved in the pathogenesis of acne vulgaris.Methods Fecal samples from 43 untreated acne patients and 43 age- and sex-matched healthy controls were collected.The disease duration,height,weight,and sleep quality of the participants were recorded.The 118 metabolites were detected using Agilent model 7890B gas chromatograph.Then the non-parametric tests were conducted to find the differences of gut metabolites between acne patients and healthy controls.Results Significant difference was found in the composition of metabolites between patients with acne vulgaris and healthy controls.There was no correlation of the metabolites with disease severity of the acne patients.Twenty-four different gut microbiota-host metabolites between patients and control group were found to be significantly different with non-parametric analysis(P<0.05).Compared with healthy controls,sleep quality was worse in patients with acne vulgaris(P<0.05).Pearson correlation analysis showed that the gut metabolites were negatively correlated with sleep quality.Conclusion Gut microbiota-host metabolites are significantly different between patients with acne vulgaris and healthy controls,which may be a link to explain the involvement of gut microbiota in the pathogenesis of acne vulgaris.

参考文献/References:

[1] Williams HC,Dellavalle RP,Garner S.Acne vulgaris [J].Lancet,2012,379(9813):361-372.
[2] 项蕾红.中国痤疮治疗指南(2014修订版)[J].临床皮肤科志,2015,44(1):52-57.
[3] Gupta MA,Pur DR,Vujcic B,et al.Suicidal behaviors in the dermatology patient[J].Clin Dermatol,2017,35(3):302-311.
[4] Deng Y,Wang H,Zhou J,et al.Patients with acne vulgaris have a distinct gut microbiota in comparison with healthy controls[J].Acta Derm Venereol,2018,98(8):783-790.
[5] Ni Y,Qiu Y,Jiang W,et al.ADAP-GC 2.0:deconvolution of coeluting metabolites from GC/TOF-MS data for metabolomics studies [J].Anal Chem,2012,84(15):6619-6629.
[6] Cani PD,Bibiloni R,Knauf C,et al.Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice[J].Diabetes,2008,57(6):1470-1481.
[7] Martinez-Medina M,Denizot J,Dreux N,et al.Western diet induces dysbiosis with increased E coli in CEABAC10 mice,alters host barrier function favouring AIEC colonisation[J].Gut,2014,63(1):116-124.
[8] Palm NW,De Zoete MR,Flavell RA.Immune-microbiota interactions in health and disease[J].Clin Immunol,2015,159(2):122-127.
[9] Sonnenburg JL,Backhed F.Diet-microbiota interactions as moderators of human metabolism[J].Nature,2016,535(7610):56-64.
[10] Song H,Yoo Y,Hwang J,et al.Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis [J].J Allergy Clin Immunol,2016,137(3):852-860.
[11] Bowe W,Patel NB,Logan AC.Acne vulgaris,probiotics and the gut-brain-skin axis:from anecdote to translational medicine[J].Benef Microbes,2014,5(2):185-199.
[12] Dodd KM,Tee AR.Leucine and mTORC1:a complex relationship [J].Am J Physiol Endocrinol Metab,2012,302(11):1329-1342.
[13] Zoncu R,Efeyan A,Sabatini DM.mTOR:from growth signal integration to cancer,diabetes and ageing [J].Nat Rev Mol Cell Biol,2011,12(1):21-35.
[14] Melnik B.Dietary intervention in acne:Attenuation of increased mTORC1 signaling promoted by Western diet [J].Dermatoendocrinol,2012,4(1):20-32.
[15] Park MY,Kim KH,Kang H,et al.Analysis of Korean acne patients according to age groups based on two multicenter studies[J].J Dermatol,2017,44(2):186-188.
[16] Bowe W,Patel NB,Logan AC.Acne vulgaris,probiotics and the gut-brain-skin axis:from anecdote to translational medicine[J].Benef Microbes,2014,5(2):185-199.
[17] Pagel R,Bar F,Schroder T,et al.Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine[J].FASEB J,2017,31(11):4707-4719.
[18] Karl JP,Hatch AM,Arcidiacono SM,et al.Effects of psychological,environmental and physical stressors on the gut microbiota[J].Front Microbiol,2018,9:2013.
[19] Leone V,Gibbons SM,Martinez K,et al.Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism[J].Cell Host Microbe,2015,17(5):681-689.
[20] Poroyko VA,Carreras A,Khalyfa A,et al.Chronicsleep disruption alters gut microbiota,induces systemic and adipose tissue inflammation and insulin resistance in mice[J].Sci Rep,2016,6:35405.

相似文献/References:

[1]郑淇,顾云东,曹艳云,等.润燥止痒胶囊治疗寻常痤疮的系统评价[J].中国皮肤性病学杂志,2018,(06):689.[doi:10.13735/j.cjdv.1001-7089.201711076]
 ZHENG Qi,GU Yundong,CAO Yanyun,et al.Runzaozhiyang Capsules in the Treatment of Acne Vulgaris:A Systematic Review[J].The Chinese Journal of Dermatovenereology,2018,(07):689.[doi:10.13735/j.cjdv.1001-7089.201711076]
[2]袁江,代国知,唐小滨,等.红、蓝光联合5%过氧化苯甲酰凝胶治疗寻常痤疮50例临床观察[J].中国皮肤性病学杂志,2013,(11):1198.
 YUAN Jiang,DAI Guo-zhi,TANG Xiao-bin,et al.Curative Effect Observation of 50 Cases Acne Vulgaris Treated by Red and Blue Light Combined with 5% Benzoyl Peroxide Gel[J].The Chinese Journal of Dermatovenereology,2013,(07):1198.
[3]麻翱,麻林玖.复方珍珠暗疮胶囊联合维胺脂胶囊及异维A酸红霉素凝胶治疗寻常痤疮68例临床观察[J].中国皮肤性病学杂志,2014,(06):656.[doi:10.13735/j.cjdv.1001-7089.2014.0656]
 MA Ao,MA Lin-Jiu.The clinical Efficacy of combination of Compound Zhenzhu Anchuang capsule, Viaminate capsule and Isotretinoin Erythromycin Gel in the Treatment of 68 Cases of Acne Vulgaris[J].The Chinese Journal of Dermatovenereology,2014,(07):656.[doi:10.13735/j.cjdv.1001-7089.2014.0656]
[4]张玉红.红蓝光治疗仪联合金花消痤丸及氯霉素酊治疗寻常痤疮疗效观察[J].中国皮肤性病学杂志,2013,(03):304.

备注/Memo

备注/Memo:
[基金项目] 四川省医学会创新青年基金(Q17084); 西南医科大学博士科研启动基金(16249)
[作者单位] 西南医科大学附属医院,四川 泸州 646000
[通讯作者] 邓永琼,E-mail:dengyongqiong1@126.com
[Corresponding author] DENG Yongqiong,E-mail:dengyongqiong1@126.com
更新日期/Last Update: 2019-06-15