[1]路坦,申春平,田晶,等.保湿润肤剂在儿童中重度特应性皮炎治疗中的辅助作用[J].中国皮肤性病学杂志,2019,(07):757-760.[doi:10.13735/j.cjdv.1001-7089.201901132]
 LU Tan,SHEN Chunping,TIAN Jing,et al.Auxiliary Effects of Emollient in Children with Moderate to Severe Atopic Dermatitis[J].The Chinese Journal of Dermatovenereology,2019,(07):757-760.[doi:10.13735/j.cjdv.1001-7089.201901132]
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保湿润肤剂在儿童中重度特应性皮炎治疗中的辅助作用
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年07期
页码:
757-760
栏目:
论著
出版日期:
2019-06-16

文章信息/Info

Title:
Auxiliary Effects of Emollient in Children with Moderate to Severe Atopic Dermatitis
文章编号:
1001-7089(2019)07-0757-04
作者:
路坦申春平田晶马琳
首都医科大学附属北京儿童医院皮肤科,北京 100045
Author(s):
LU TanSHEN ChunpingTIAN JingMA Lin
(Department of Dermatology,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China)
关键词:
糖皮质激素 润肤剂 儿童 特应性皮炎
Keywords:
Glucocorticoids Emollients Children Atopic dermatitis
分类号:
R 758.2
DOI:
10.13735/j.cjdv.1001-7089.201901132
文献标志码:
A
摘要:
目的 探讨外用保湿润肤剂对儿童中重度特应性皮炎外用糖皮质激素治疗的辅助作用。方法 采用自身对照的研究设计,入组2~12岁中重度特应性皮炎患儿,试验部位(左肘屈侧)予糖皮质激素(0.1%糠酸莫米松乳膏)1次/d联合保湿润肤剂2次/d治疗,对照部位(右肘屈侧)予糖皮质激素(0.1%糠酸莫米松乳膏)1次/d治疗,分别于治疗后1周、2周、4周随访,进行无创皮肤参数测定、记录0.1%糠酸莫米松用量。结果 共入组2~12岁中重度AD患儿36例,完成随访30例,治疗14 d、28 d随访时试验部位激素用量较对照部位减少,试验部位pH值较对照部位低,差异有统计学意义(P<0.05); 治疗后28 d随访,试验部位皮肤角质层含水量较对照部位高,差异有统计学意义(P<0.05)。结论 儿童中重度特应性皮炎使用保湿润肤剂辅助治疗,可有效减少外用糖皮质激素用量,同时对修复皮肤屏障有辅助作用。
Abstract:
Objective To observe the auxiliary role of topical emollient in topical glucocorticoid therapy in children with moderate to severe atopic dermatitis(AD).Methods Using a self-controlled study design,children aged 2~12 years with moderate to severe AD were enrolled.The test site(left elbow flexion)was given glucocorticoid(0.1% mometasone furoate cream)once daily combined with emollient twice a day,while the control site(right elbow flexion)was given glucocorticoid(0.1% mometasone furoate cream)once daily.They were followed up at 1 week,2 weeks,and 4 weeks after treatment.Non-invasive skin parameters were measured and the amount of 0.1% mometasone furoate was recorded.Results Thirty-six children aged 2~12 years with moderate to severe AD were enrolled in the study.Thirty children who were followed up were included in the analysis.At the 14th and 28th day of follow-up,the amount of glucocorticoid in the test site was decreased compared with the control site,the pH value of the test site was lower than that of the control site,and the difference was statistically significant(P<0.05).After 28 days of treatment,the water content of the stratum corneum of the test site was higher than that of the control site,and the difference was statistically significant(P<0.05).Conclusion In children with moderate to severe AD,emollients,as an auxiliary therapy,can effectively reduce the amount of topical glucocorticoids used,and help to repair the skin barrier.

参考文献/References:

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[3] Msika P,De Belilovsky C,Piccardi N,et al.New emollient with topical corticosteroid-sparing effect in treatment of childhood atopic dermatitis:SCORAD and quality of life improvement[J].Pediatr Dermatol,2008,25(6):606-612.
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备注/Memo

备注/Memo:
[作者单位] 首都医科大学附属北京儿童医院皮肤科,北京 100045
[通讯作者] 马琳,E-mail:bch_maleen@aliyun.com
[Corresponding author] MA Lin,E-mail:bch_maleen@aliyun.com
更新日期/Last Update: 2019-06-15