[1]陈文慧,刘乐,赵玢,等.盐酸奥洛他定联合曲尼司特治疗慢性荨麻疹疗效观察[J].中国皮肤性病学杂志,2019,(06):734-737.[doi:10.13735/j.cjdv.1001-7089.201804019]
 CHEN Wenhui,LIU Le,ZHAO Bin,et al.Clinical Observation of Olopatadine Hydrochloride Combined with Tranilast in the Treatment of Chronic Urticaria[J].The Chinese Journal of Dermatovenereology,2019,(06):734-737.[doi:10.13735/j.cjdv.1001-7089.201804019]
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盐酸奥洛他定联合曲尼司特治疗慢性荨麻疹疗效观察
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年06期
页码:
734-737
栏目:
药物与临床
出版日期:
2019-05-16

文章信息/Info

Title:
Clinical Observation of Olopatadine Hydrochloride Combined with Tranilast in the Treatment of Chronic Urticaria
文章编号:
1001-7089(2019)06-0734-04
作者:
陈文慧1刘乐1赵玢1李伯埙2
1.陕西省皮肤性病防治所,陕西 西安 710003; 2.西安交通大学第二附属医院,陕西 西安 710004
Author(s):
CHEN Wenhui1LIU Le1ZHAO Bin1 LI Boxun2
(1.The Shaanxi Provincial Institute of Dermatovenereology,Xi'an 710003,China; 2.The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)
关键词:
盐酸奥洛他定 曲尼司特 荨麻疹
Keywords:
Olopatadine hydrochloride Tranilast Urticaria
分类号:
R 758.24
DOI:
10.13735/j.cjdv.1001-7089.201804019
文献标志码:
B
摘要:
目的 评价盐酸奥洛他定联合曲尼司特治疗慢性荨麻疹的临床疗效及安全性。方法 共入选129例慢性荨麻疹患者,随机分为治疗组、对照A组和对照B组,治疗组患者口服盐酸奥洛他定片5 mg,2次/d,同时口服曲尼司特胶囊100 mg,3次/d; 对照A组单纯口服盐酸奥洛他定片5 mg,2次/d; 对照B组单纯口服曲尼司特胶囊100 mg,3次/d; 三组疗程均为4周。结果 治疗2周和4周后,治疗组和对照组症状积分均较治疗前下降,治疗2周后治疗组与对照A组症状积分差异无统计学意义(P>0.05),与对照B组差异有统计学意义(P<0.05); 治疗4周后,治疗组与对照A、B组症状积分差异均有统计学意义(P均<0.05); 治疗2周后,三组有效率分别为69.77%、59.52%和45.24%,治疗组与对照A组差异无统计学意义(P>0.05),与对照B组差异有统计学意义(P<0.05); 治疗4周后,三组的有效率分别为90.70%、71.43%和59.52%,治疗组与对照A、B组差异均有统计学意义(P均<0.05)。三组治疗中均无严重不良反应发生。结论 盐酸奥洛他定联合曲尼司特治疗慢性荨麻疹疗效确切,安全性好。
Abstract:
Objective To evaluate the clinical efficacy and safety of olopatadine hydrochloride combined with tranilast in the treatment of chronic urticaria.Methods Totally 129 patients with chronic urticaria were randomly divided into three groups including treatment group,control group A,control group B.The patients in treatment group were given 5 mg olopatadine hydrochloride twice daily and 100 mg tranilast capsule three times daily; the patients in control group A were given 5 mg olopatadine hydrochloride twice daily; the patients in control group B were given 100 mg tranilast capsule three times daily.The patients in the three groups took medicine four weeks continuously.Results After 2,4 weeks of treatment,the clinical symptom score of three groups declined more dramatically,but there was no significant difference between the treatment group and the control group A after two weeks(P >0.05).After two weeks of treatment,the effective rates of three groups was 69.77%,59.52%,45.24%,respectively.There was no significant difference between the treatment group and the control group A(P>0.05).After 4 weeks of treatment,the effective rates of three groups was 90.70%,71.43%,59.52%,respectively.There was significant difference between the treatment group and the control group(P< 0.05).There were no obvious adverse reactions in the three groups during the treatment period.Conclusion Olopatadine hydrochloride combined with tranilast is effective and safe in the treatment of chronic urticaria.

参考文献/References:


[1] 张建中.中外皮肤病诊疗指南[M].北京:中华医学电子影像出版社,2014:29-36.
[2] Nishiyama S,Okamoto S,Ishibashi Y,et al.Phase Ⅲ study of KW-4679(olopatadine hydrochloride)on chronic urticaria [J].J Clin Ther Med,2001,17(3):237-264.
[3] 翟志芳,韦应波,雷铁池,等.盐酸奥洛他定治疗慢性自发性荨麻疹多中心、随机、双盲、平行对照临床研究[J].中华皮肤科杂志,2015,48(12):831-834.
[4] 赵建华,乔少华,耿文军,等.左西替利嗪、曲尼司特联合卡介苗素治疗慢性荨麻疹的临床观察[J].中国皮肤性病学杂志,2010,24(7):683-684.
[5] 马孝,康丽,付敏.地氯雷他定联合曲尼司特治疗慢性荨麻疹疗效观察[J].中国医药,2013,8(2):221-222.
[6] 刘玲玲,朱学骏,姜薇,等.咪唑斯汀治疗慢性荨麻疹的随机双盲研究[J].中华皮肤科杂志,2003,36(6):306-309.
[7] Kocatürk E,Maurer M,Metz M,et al.Looking forward to new targeted treatments for chronic spontaneous urticaria[J].Clin Transl Allergy,2017,4(3):7-11.
[8] Zuberbier T,Aberer W,Asero R,et al.The EAACI/GA(2)LEN/EDF/WAO Guideline for the definition,classification,diagnosis,and management of urticaria:the 2013 revision and update[J].Allergy,2014,69(7):868-887.
[9] Ohmori K,Hayashi K,Kaise T,et al.Pharmacological,pharmacokinetic and clinical properties of olopatadine hydrochloride,a new antiallergic drug[J].Jpn J Pharmacol,2002,88(4):379-397.
[10] Quan L,He H.Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation,NGF and VEGF[J].Mol Med Rep,2016,13(4):3319-3325.
[11] Kishimoto K,Kaneko S,Ohmori K,et al.Olopatadine suppresses the migration of THP-1 monocytes induced by S100A12 protein[J].Mediators Inflamm,2006,2006(1):42726.
[12] Dakhale G,Tathod Y,Patel S,et al.Comparison of efficacy,safety,and cost-effectiveness of rupatadine and olopatadine in patients of allergic rhinitis:A prospective,randomized,double-blind,parallel group study[J].J Pharmacol Pharmacother,2016,7(4):171-176.
[13] Dakhale GN,Wankhede SS,Mahatme MS,et al.Comparison of efficacy,safety and cost-effectiveness of rupatadine and olopatadine in patients of chronic spontaneous urticaria:a randomized,double-blind,comparative,parallel group trial[J].Indian J Dermatol,2016,61(1):63-69.
[14] Sil A,Tripathi SK,Chaudhuri A,et al. Olopatadine versus levocetirizine in chronic urticaria:an observer-blind,randomized,controlled trial of effectiveness and safety[J].J Dermatolog Treat,2013,24(6):466-472.
[15] Kamei H,Isaji A,Noda Y,et al.Effects of single therapeutic doses of promethazine,fexofenadine and olopatadine on psychomotor function and histamine-induced wheal-and flare-responses:a randomized double-blind,placebo-controlled study in healthy volunteers[J].Arch Dermatol Res,2012,304(4):263-272.
[16] 曹元华,董自立,靳培英.曲尼司特的研究进展及其在皮肤科的应用[J].中国麻风皮肤病杂志,2002,18(2):156-158.
[17] 邹晴,郭在培.曲尼司特药理作用研究进展[J].中国麻风皮肤病杂志,2008,24(3):216-218.
[18] 吴潞明,张超,邹勇莉.盐酸非索非那丁联合曲尼司特治疗慢性荨麻疹疗效观察[J].皮肤病与性病,2012,34(3):156-157.
[19] 潘武辉.依匹斯汀联合曲尼司特治疗慢性荨麻疹的疗效分析[J].白求恩军医学院学报,2013,11(4):346-347.

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备注/Memo

备注/Memo:
[作者单位] 1.陕西省皮肤性病防治所,陕西 西安 710003; 2.西安交通大学第二附属医院,陕西 西安 710004
更新日期/Last Update: 2019-05-16