[1]罗璇,王华.新生儿红斑狼疮研究进展[J].中国皮肤性病学杂志,2019,(06):717-720.[doi:10.13735/j.cjdv.1001-7089.201805184]
 LUO Xuan,WANG Hua.Updates on Neonatal Lupus Erythematosus[J].The Chinese Journal of Dermatovenereology,2019,(06):717-720.[doi:10.13735/j.cjdv.1001-7089.201805184]
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新生儿红斑狼疮研究进展
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年06期
页码:
717-720
栏目:
综述
出版日期:
2019-05-16

文章信息/Info

Title:
Updates on Neonatal Lupus Erythematosus
文章编号:
1001-7089(2019)06-0717-04
作者:
罗璇王华
重庆医科大学儿童医院皮肤科,重庆 400014
Author(s):
LUO XuanWANG Hua
(Department of Dermatology,Children's Hospital of Chongqing Medical University,Chongqing 400014,China)(Department of Dermatology,Children's Hospital of Chongqing Medical University,Chongqing 400014,China
关键词:
新生儿红斑狼疮 SSA抗体 SSB抗体 先天性心脏传导阻滞
Keywords:
Neonatal lupus erythematosus SSA-antibodies SSB-antibodies Congenital heart block
分类号:
R 593.24; R 722
DOI:
10.13735/j.cjdv.1001-7089.201805184
文献标志码:
A
摘要:
新生儿红斑狼疮(neonatal lupus erythematosus,NLE)是由于母亲体内的自身抗体(主要为SSA抗体和SSB抗体)通过胎盘进入胎儿,在胎儿体内引起自身免疫反应所致。临床表现主要为皮肤环形红斑和先天性心脏传导阻滞(congenital heart block,CHB),也可伴有消化、血液、呼吸、神经系统等不同程度的损害。该病具有自限性,随着母亲抗体从患儿血液循环中清除,患儿临床症状逐渐缓解,但心脏病变常持续存在且是造成患儿死亡的主要病因。
Abstract:
Neonatal lupus erythematosus(NLE)is an acquired autoimmune disease that is associated with maternal autoantibodies,especially anti-Sjogren's syndrome antigen A(SSA)/SSB,which can transmit across the placenta.Annular skin erythema and congenital heart block are the typical clinical manifestations.Meanwhile,the hepatobiliary,respiratory,hematologic and nervous system are also involved.NLE is a self-limited disease because maternal autoantibodies can be cleared from the circulation over time.The symptoms of NLE can improve gradually,however,heart involvement is mostly permanent and exists as a major cause of death in the patients with NLE.

参考文献/References:


[1] Buyon JP.Systemic Lupus Erythematosus [M].4th Ed.San Diego:Academic Press,2004:449-484.
[2] Izmirly PM,Saxena A,Kim MY,et al.Maternal and fetal factors associated with mortality and morbidity in a multi-racial/ethnic registry of anti-SSA/Ro-associated cardiac neonatal lupus[J].Circulation,2011,124(18):1927-1935.
[3] Silverman E,Jaeggi E.Non-cardiac manifestations of neonatal lupus erythematosus[J].Scand J Immunol,2010,72(3):223-225.
[4] Hon KL,Leung AK.Neonatal lupus erythematosus[J].Autoimmune Dis,2012,2012(1):301274.
[5] McCuistion CH,Schoch EP.Possible discoid lupus erythematosus in newborn infant.Report of a case with subsequent development of acute systemic lupus erythematosus in mother[J].AMA Arch Dermatol Syphilol,1954,70(6):782-785.
[6] Li YQ,Wang Q,Luo Y,et al.Neonatal lupus erythematosus:a review of 123 cases in China[J].Int J Rheum Dis,2015,18(7):761.
[7] Wisuthsarewong W,Soongswang J,Chantorn R.Neonatal lupus erythematosus:clinical character,investigation,and outcome[J].Pediatr Dermatol,2011,28(2):115-121.
[8] Kobayashi R,Mii S,Nakano T,et al.Neonatal lupus erythematosus in Japan:a review of the literature[J].Autoimmun Rev,2009,8(6):462-466.
[9] Maddison PJ.Anti-Ro antibodies and neonatal lupus[J].Clin Rheumatol,1990,9(1 Suppl 1):116-121.
[10] Askanase AD,Izmirly PM,Katholi M,et al.Frequency of neuro-psychiatric dysfunction in anti-SSA/SSB exposed children with and without neonatal lupus[J].Lupus,2010,19(3):300-306.
[11] Klein-Gitelman MS.Neonatal lupus:what we have learned and current approaches to care[J].Curr Rheumatol Rep,2016,18(9):60.
[12] Teixeira AR,Rodrigues M,Guimarães H,et al.Neonatal lupus-case series of a tertiary hospital[J].Acta Reumatol Port,2017,42(4):318-323.
[13] Inzinger M,Salmhofer W,Binder B.Neonatal lupus erythematosus and its clinical variability[J].J Dtsch Dermatol Ges,2012,10(6):407-411.
[14] Liu RF,Chung WH,Yang CY,et al.Neonatal lupus erythematosus presenting as Stevens-Johnson syndrome[J].Dermatologica Sinica,2018,36(2):97-100.
[15] Yildirim A,Tunaoolu FS,Karaaoac AT.Neonatal congenital heart block [J].Indian Pediatr,2013,50(5):483-488.
[16] Ambrosi A,Sonesson SE,Wahren-Herlenius M.Molecular mechanisms of congenital heart block[J].Exp Cell Res,2014,325(1):2-9.
[17] Johnson B.Overview of neonatal lupus[J].J Pediatr Health Care,2014,28(4):331-341.
[18] Chao MM,Luchtman-Jones L,Silverman RA.Hematological complications of neonatal lupus:case report and review of the literature[J].J Pediatr Hematol Oncol,2013,35(8):e344-346.
[19] Chen CC,Lin KL,Chen CL,et al.Central nervous system manifestations of neonatal lupus:a systematic review[J].Lupus,2013,22(14):1484-1488.
[20] 周志轩,吴凤岐,赖建铭,等.新生儿红斑狼疮12例临床特征和远期随访[J].中国循证儿科杂志,2009,4(6):504-508.
[21] Izmirly PM,Halushka MK,Rosenberg AZ,et al.Clinical and pathologic implications of extending the spectrum of maternal autoantibodies reactive with ribonucleoproteins associated with cutaneous and now cardiac neonatal lupus from SSA/Ro and SSB/La to U1RNP[J].Autoimmun Rev,2017,16(9):980-983.
[22] Barsalou J,Jaeggi E,Laskin CA,et al.Prenatal exposure to antimalarials decreases the risk of cardiac but not non-cardiac neonatal lupus:a single-centre cohort study[J].Rheumatol,2017,56(9):1552-1559.
[23] Clancy RM,Alvarez D,Komissarova E,et al.Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs:a novel pathway to autoimmune-associated heart block[J].J Immunol,2010,184(4):2148-2155.
[24] Sacre K,Criswell LA,Mc Cune JM.Hydroxychloroquine is associated with impaired interferon-alpha and tumor necrosis factor-alpha production by plasmacytoid dendritic cells in systemic lupus erythematosus[J].Arthritis Res Ther,2012,14(3):R155.
[25] Lazzaroni MG,Dall'Ara F,Fredi M,et al.A comprehensive review of the clinical approach to pregnancy and systemic lupus erythematosus[J].J Autoimmun,2016,74:106-117.
[26] Rivera TL,Izmirly PM,Birnbaum BK,et al.Disease progression in mothers of children enrolled in the Research Registry for Neonatal Lupus[J].Ann Rheum Dis,2009,68(6):828-835.
[27] Martin V,Lee LA,Askanase AD,et al.Long-term followup of children with neonatal lupus and their unaffected siblings[J].Arthritis Rheum,2002,46(9):2377-2383.

相似文献/References:

[1]罗璇,王华.新生儿红斑狼疮23例临床特点及随访分析[J].中国皮肤性病学杂志,2019,(09):1031.[doi:10.13735/j.cjdv.1001-7089.201810102]
 LUO Xuan,WANG Hua.Clinical Analysis and Follow-up of 23 Cases of Neonatal Lupus Erythematosus[J].The Chinese Journal of Dermatovenereology,2019,(06):1031.[doi:10.13735/j.cjdv.1001-7089.201810102]

备注/Memo

备注/Memo:
[作者单位] 重庆医科大学儿童医院皮肤科,重庆 400014
[通讯作者] 王华,E-mail:huawang63@hotmail.com
更新日期/Last Update: 2019-05-16