[1]王思宇,孙超楠,沈柱.组织常驻记忆性T细胞参与银屑病复发的研究进展[J].中国皮肤性病学杂志,2019,(06):704-708.[doi:10.13735/j.cjdv.1001-7089.201807092]
 WANG Siyu,SUN Chaonan,SHEN Zhu.Tissue Resident Memory T Cells in Psoriasis Recurrence[J].The Chinese Journal of Dermatovenereology,2019,(06):704-708.[doi:10.13735/j.cjdv.1001-7089.201807092]
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组织常驻记忆性T细胞参与银屑病复发的研究进展
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年06期
页码:
704-708
栏目:
综述
出版日期:
2019-05-16

文章信息/Info

Title:
Tissue Resident Memory T Cells in Psoriasis Recurrence
文章编号:
1001-7089(2019)06-0704-05
作者:
王思宇1孙超楠12沈柱12
1.四川省医学科学院·四川省人民医院皮肤病性病研究所,四川 成都 610072; 2.电子科技大学医学院,四川 成都 610054
Author(s):
WANG Siyu1SUN Chaonan12SHEN Zhu12
(1.Department of Dermatology,Institute of Dermatology and Venereology,Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital,Chengdu 610072,China; 2.Affiliated Hospital of University of Electronic Science and Technology of China & Sichuan Provincial People's Hospital,Chengdu 610054,China)
关键词:
银屑病 组织常驻记忆性T细胞 外周驻留 长期存活 低迁徙
Keywords:
Psoriasis Tissue resident memory T cells Peripheral residence Long-lived survival Low migration
分类号:
R 758.63
DOI:
10.13735/j.cjdv.1001-7089.201807092
文献标志码:
A
摘要:
皮损反复发作是银屑病重要的临床特点和治疗难点之一,且复发常可位于原皮损消退区域,提示银屑病的复发与“免疫记忆”有关。皮肤组织常驻记忆性T细胞(tissue resident memory T cells,TRM)是记忆性T细胞中的重要亚群,具有在皮肤中长期存活(long-lived)和低迁移(lowmigration)的显著特点。研究提示,TRM细胞在银屑病复发中发挥重要作用,本文就TRM细胞的生物学特性及其参与银屑病复发的研究进展进行综述。
Abstract:
Recurrence is one of the important clinical features and treatment obstacles of psoriasis.Its recurrence often occurs in the remission area of the primary lesions,suggesting that the recurrence of psoriasis is related to the “immune memory”.Tissue resident memory T cells(TRM)are the important members of memory T cells.The permanent characteristics of TRM cells have the features of long-lived survival and lowmigration in the skin.It has been suggested that the TRM cells play an important role in the recurrence of psoriasis.This article reviews the research progress of biological characteristics of TRM cells and their participation in the recurrence of psoriasis.

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备注/Memo

备注/Memo:
[基金项目] 国家自然科学基金面上项目(81573054); 四川省医学科学院·四川省人民医院临床研究与转化重点项目(2016LZ02)
[作者单位] 1.四川省医学科学院·四川省人民医院皮肤病性病研究所,四川 成都 610072; 2.电子科技大学医学院,四川 成都 610054
[通讯作者] 沈柱,E-mail:zhshencq@163.com
更新日期/Last Update: 2019-05-16