[1]赵洁,曾雪,王俊慧,等.毛发-牙-骨综合征1例[J].中国皮肤性病学杂志,2019,(06):698-700.[doi:10.13735/j.cjdv.1001-7089.201810043]
 ZHAO Jie,ZENG Xue,WANG Junhui,et al.A Case of Tricho-Dento-Osseous Syndrome[J].The Chinese Journal of Dermatovenereology,2019,(06):698-700.[doi:10.13735/j.cjdv.1001-7089.201810043]
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毛发-牙-骨综合征1例
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年06期
页码:
698-700
栏目:
病例报告
出版日期:
2019-05-16

文章信息/Info

Title:
A Case of Tricho-Dento-Osseous Syndrome
文章编号:
1001-7089(2019)06-0698-03
作者:
赵洁曾雪王俊慧崔炳南
中国中医科学院广安门医院皮肤科,北京 100053
Author(s):
ZHAO JieZENG XueWANG JunhuiCUI Bingnan
(Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)
关键词:
脱发 毛发-牙-骨综合征
Keywords:
Hair loss Tricho-Dento-Osseous syndrome
分类号:
R 596.1
DOI:
10.13735/j.cjdv.1001-7089.201810043
文献标志码:
B
摘要:
患者女,28岁,头发稀疏脱落10余年,加重1年。头发稀疏减少,发质硬,似钢丝,不易折断,前额突出; 双手指甲薄且脆,表面凹凸不平,双足趾甲小、薄、脆,部分缺如; 牙齿小,牙间隙增宽。头皮组织病理角质层呈网篮状,表皮基本正常,真皮内胶原纤维增加,毛囊数量明显减少,毛囊周围可见少量淋巴细胞浸润,可见已纤维化毛囊。诊断:毛发-牙-骨综合征。
Abstract:
A 28-year-old female had hair loss for more than 10 years and aggravated for one year.The hair was hard and sparsely reduced.Her forehead was prominent,and her nails were thin and brittle.The surface of the nails were uneven,the toenails were small,thin,brittle and partially absent.Her teeth were small and the interdental space was widened.The scalp tissue pathological stratum corneum was net-like,the epidermis was basically normal,the collagen fibers in the dermis increased,the number of hair follicles significantly reduced,and a small amount of lymphocytes infiltrated around the hair follicle,the fibrotic hair follicles were seen.Tricho-dento-osseous syndrome was diagnosed.

参考文献/References:


[1] Price JA,Bowden DW,Wright JT,et al.Identification of a mutation in DLX3 associated with tricho-dento-osseous(TDO)syndrome[J].Hum Mol Genet,1998,7(3):563-569.
[2] 李玥,韩冬,赵娜,等.毛-牙-骨综合征基因检测及形态学研究[C].第八次全国口腔修复学学术年会论文汇编,2014:45.
[3] Jain P,Kaul R,Saha S,et al.Tricho-dento-osseous syndrome and precocious eruption[J].J Clin Exp Dent,2017,9(3):e494-497.
[4] Mayer DE,Baal C,Litschauer-Poursadrollah M,et al.Uncombable hair and atopic dermatitis in a case of tricho-dento-osseous syndrome[J].J Dtsch Dermatol Ges,2010,8(2):102-103.
[5] 赵辨.中国临床皮肤病学[M].江苏:江苏科学技术出版社,2010:1717.
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备注/Memo

备注/Memo:
[作者单位] 中国中医科学院广安门医院皮肤科,北京 100053
[通讯作者] 崔炳南,E-mail:cbn1998@163.com
更新日期/Last Update: 2019-05-16