[1]郭碧蓉,蔡海斌,周欣,等.口腔外疣状黄瘤10例临床表现与组织病理分析[J].中国皮肤性病学杂志,2019,(06):674-678.[doi:10.13735/j.cjdv.1001-7089.201809027]
 GUO Birong,CAI Haibin,ZHOU Xin,et al.Clinicopathological Analysis of 10 Cases with Verrucous Xanthoma Locating in the External Position of Oral Cavity[J].The Chinese Journal of Dermatovenereology,2019,(06):674-678.[doi:10.13735/j.cjdv.1001-7089.201809027]
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口腔外疣状黄瘤10例临床表现与组织病理分析
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年06期
页码:
674-678
栏目:
临床经验
出版日期:
2019-05-16

文章信息/Info

Title:
Clinicopathological Analysis of 10 Cases with Verrucous Xanthoma Locating in the External Position of Oral Cavity
文章编号:
1001-7089(2019)06-0674-05
作者:
郭碧蓉1蔡海斌2周欣3李卉4
1.安徽医科大学第三附属医院,合肥市第一人民医院皮肤科,安徽 合肥 230061; 2.上海市浦东新区人民医院皮肤科,上海 201299; 3.广州市皮肤病防治所,广东 广州 510095; 4.安徽医科大学第一附属医院皮肤科,安徽 合肥 230022
Author(s):
GUO Birong1CAI Haibin2ZHOU Xin3LI Hui4
(1.Department of Dermatology,the Third Affiliated Hospital of Anhui Medical University,the First People's Hospital of Hefei,Hefei 230061,China; 2.Department of Dermatology,the People's Hospital of Pudong New Area,Shanghai 201299,China,3.The Skin Disease Prevention and Treatment Hospital of Gangzhou,Guangzhou 510095,China; 4.Department of Dermatology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China )
关键词:
疣状黄瘤 临床表现 病理
Keywords:
Verrucous xanthoma Clinical manifestations Pathology
分类号:
R 758.6
DOI:
10.13735/j.cjdv.1001-7089.201809027
文献标志码:
B
摘要:
目的 探讨发生口腔外疣状黄瘤患者的临床及病理特征。方法 回顾性分析10例口腔外疣状黄瘤患者的临床和病理资料。结果 10例患者中,男8例,女2例,其中7例发生在会阴部位(阴囊,龟头)。临床误诊为尖锐湿疣3例,皮肤纤维瘤2例,疣状痣、增殖性红斑、皮脂腺痣、毛发上皮瘤及化脓性肉芽肿各1例,无临床疑诊为疣状黄瘤病例。10例患者经组织病理确诊均符合疣状黄瘤。结论 口腔外疣状黄瘤皮损临床上与多种疾病相似,误诊率极高。组织病理学有特征性改变,是诊断疾病的重要依据。
Abstract:
Objective To investigate the clinical and pathological features of verrucous xanthoma locating in the external position of oral cavity.Methods The data of 10 cases with verrucous xanthoma was analyzed retrospectively.Results Out of the 10 cases,8 were male,2 were female,and 7 cases were located in the perineum(scrotum,penis glans).The clinical diagnosis included 3 cases of condyloma acuminatum,2 cases of cutaneous fibroma,1 case of verrucous nevus,1 case of proliferative erythema,1 case of sebaceous nevus,1 case of trichoepithelioma and 1 case of suppurative granuloma.The pathological features were in accordance with the diagnosis of verrucous xanthoma in all of the 10 patients. Conclusion The lesions of verrucous xanthoma are clinically similar to many diseases and the misdiagnosis rate is high.Histopathology with characteristic changes is an important basis for the diagnosis.

参考文献/References:


[1] Shafer WG.Verruciform xanthoma[J].Oral Surg Oral Med Oral Pathol,1971,31(6):784-789.
[2] 孙建方,高天文,涂平,等.麦基皮肤病理学—与临床的联系[M].4版.北京:北京大学出版社,2017:522-524.
[3] 苏飞,黄萌,陈柳青,等.包皮疣状黄瘤1例[J].中国皮肤性病学杂志,2018,32(1):75-76.
[4] Philipsen HP,Reichart PA,Takata T,et al. Verruciform xanthoma-biological profile of 282 oral lesions based on a literature survey with nine new cases from Japan[J].Oral Oncol,2003,39(4):325-336.
[5] Gill BJ,Chan AJ,Hsu S.Verruciform xanthoma[J].Dermatol Online J,2014,20(1):21253.
[6] 李清,钟萍,陆原,等.阴囊疣状黄瘤1例[J].中国皮肤性病学杂志,2013,27(4):391-392.
[7] Hegde U,Doddawad VG,Sreeshyla H,et al.Verruciform xanthoma:a view on the concepts of its etiopathogenesis[J].J Oral Maxillofac Pathol,2013,17(3):392-396.
[8] Ide F,Obara K,Yamada H,et al.Cellular basis of verruciform xanthoma:immunohistochemical and ultrastructural characterization[J].Oral Dis,2008,14(2):150-157.
[9] Oliveira PT,Jaeger RG,Cabral LA,et al.Verruciform xanthoma of the oral mucosa.Report of four cases and a review of the literature[J].Oral Oncol,2001,37(3):326-331.
[10] Stiff KM,Cohen PR.Vegas(Verruciform Genital-Associated)Xanthoma:A comprehensive literature review[J].Dermatol Ther(Heidelb),2017,7(1):65-79.
[11] Shahrabi Farahani S,Treister NS,Khan Z,et al.Oral verruciform xanthoma associated with chronic graft-versus-host disease:a report of five cases and a review of the literature[J].Head Neck Pathol,2011,5(2):193-198.
[12] De Andrade BA,Agostini M,Pires FR,et al.Oral verruciform xanthoma:a clinicopathologic and immunohistochemical study of 20 cases[J].J Cutanathol,2015,42(7):489-495.
[13] Khaskhely NM,Uezato H,Kamiyama T.Association of human papillomavirus type 6 with a verruciform xanthoma[J].Am J Dermatopathol,2000,22(5):447-452.
[14] Anbinder AL,Quirino MR,Brandão AA.Verruciform xanthoma and neurofibromatosis:a case report[J].Br J Oral Maxillofac Surg,2011,49(4):e6-7.
[15] Fite C,Plantier F,Dupin N,et al.Vulvar verruciform xanthoma:ten cases associated with lichen sclerosus,lichen planus,or other conditions[J].Arch Dermatol,2011,147(9):1087-1092.
[16] Aggarwal S,Aggarwal A,Gill S,et al.Verruciform xanthoma of oral cavity-a case report[J].J Clin Diagn Res,2014,8(7):FD11-12.
[17] Guo Y,Dang Y,Toyohara JP,et al.Successful treatment of verruciform xanthoma with imiquimod[J].J Am Acad Dermatol,2013,69(4):e184-186.

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备注/Memo

备注/Memo:
[基金项目] 国家自然科学基金项目(81301352); 安徽省合肥市卫计委应用项目(hwk2017yb008); 合肥市学术和技术带头人及后备人选科研项目(2018547); 上海市浦东新区卫计委重点专科(PWZzk-2017-28)
[作者单位] 1.安徽医科大学第三附属医院,合肥市第一人民医院皮肤科,安徽 合肥 230061; 2.上海市浦东新区人民医院皮肤科,上海 201299; 3.广州市皮肤病防治所,广东 广州 510095; 4.安徽医科大学第一附属医院皮肤科,安徽 合肥 230
更新日期/Last Update: 2019-05-16