WANG Yimeng,ZHANG Chunlei.Progress in Molecular Mechanisms Relating to the Onset of Cutaneous T-cell Lymphoma[J].The Chinese Journal of Dermatovenereology,2019,(05):580-584.[doi:10.13735/j.cjdv.1001-7089.201809002]





Progress in Molecular Mechanisms Relating to the Onset of Cutaneous T-cell Lymphoma
WANG YimengZHANG Chunlei
(Department of Dermatology,Peking University Third Hospital,Beijing 100191,China)
Cutaneous T-cell lymphomaMolecular mechanismSignal pathwayGene
R 739.5
皮肤T细胞淋巴瘤(cutaneous T-cell lymphoma,CTCL)代表了一类由皮肤归巢恶性T淋巴细胞克隆性增生引起的疾病。CTCL发病机制复杂,目前尚不明确。公认的与CTCL发生密切相关的分子机制包括JAK/STAT、MAPK、NOTCH通路的失调,以及一些原癌/抑癌基因的异常以及非编码RNA引起的表观遗传学的变化等。本文对CTCL相关的分子机制的研究进展进行综述。
Cutaneous T-cell lymphomas (CTCLs) represent a heterogeneous group of neoplasms caused by skin-homing malignant T-lymphocytes.Currently, the pathogenesis of CTCL is complex and unclear.It generally accepted that the molecular mechanisms involved in the onset of CTCL include dysregulation of JAK/STAT, MAPK and NOTCH signal pathways, abnormal oncogenes/tumor suppressor genes and epigenetic changes caused by non-coding RNA.In this article, we overview recent progress in molecular mechanisms of CTCL.


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[基金项目]国家自然科学基金面上项目( 81372915)
[作者单位] 北京大学第三医院皮肤科,北京100191
[通讯作者] 张春雷,E-mail: zhangchunleius@163.com
更新日期/Last Update: 2019-04-15