[1]何波,农丽萍,黎舒,等.南宁市农村地区结核病患者HIV感染状况分析[J].中国皮肤性病学杂志,2019,(05):553-559.[doi:10.13735/j.cjdv.1001-7089.201805093]
 HE Bo,NONG Liping,LI Shu,et al.Analysis of HIV Infection in Tuberculosis Patients in Rural Areas of Nanning City[J].The Chinese Journal of Dermatovenereology,2019,(05):553-559.[doi:10.13735/j.cjdv.1001-7089.201805093]
点击复制

南宁市农村地区结核病患者HIV感染状况分析
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年05期
页码:
553-559
栏目:
性传播疾病
出版日期:
2019-04-01

文章信息/Info

Title:
Analysis of HIV Infection in Tuberculosis Patients in Rural Areas of Nanning City
文章编号:
1001-7089(2019)05-0553-07
作者:
何波农丽萍黎舒陈文才农梦妮岑平林倩姚敏 李斯斯
广西南宁市疾病预防控制中心,广西 南宁530023
Author(s):
HE Bo NONG Liping LI Shu CHEN WencaiNONG Mengni CEN Ping LIN Qian YAO Min LI Sisi
(Nanning City Center for Disease Control and Prevention in Guangxi, Nanning 530023, China)
关键词:
结核病艾滋病病毒双重感染农村地区
Keywords:
TuberculosisHIVCo-infectionRural areas
分类号:
R 52;R 512.91
DOI:
10.13735/j.cjdv.1001-7089.201805093
文献标志码:
B
摘要:
目的了解南宁市农村地区结核病(TB)患者中艾滋病病毒(HIV)感染情况,为今后的防治工作提供科学依据。方法2015-2017年在南宁市所辖的县级结核病防治机构门诊对新登记的结核病患者进行HIV抗体初筛,初筛阳性者标本送市级疾病预防控制中心进行确证,并按照年份、不同县等人口学特征进行分析。结果2015-2017年南宁市所辖的4个县级结核病防治机构门诊共诊断登记TB患者5 031例,TB患者中HIV抗体检测率为88.33%(4 444/5 031)。其中查出HIV抗体阳性29例,HIV感染率为0.65%(29/4 444),各年间的差异无统计学意义(χ2=5.493,P>0.05)。按县分布看,LA县HIV感染率最高(1.11%),但各县之间的差异无统计学意义(χ2=4.752,P>0.05)。TB/HIV双重感染患者的传播途径以异性性接触传播为主。多因素分析显示:50岁及以上年龄段(OR=2.823, 95%CI: 1.332~5.991)、治疗结局为死亡者(OR=7.832, 95%CI: 3.951~7.817)是结核病患者感染HIV的危险因素(OR>1),女性(OR=0.661, 95%CI: 0.588~0.744)是合并HIV感染率低(OR<1)。结论南宁市农村地区结核病患者的HIV感染率处于中等水平;50岁及以上中老年男性人群是TB/HIV双重感染防治工作的重点关注对象;应进一步加强结核病患者HIV筛查监测和宣传干预工作,尽早发现、规范治疗和管理TB/HIV双重感染患者,减少结核病/艾滋病的感染和传播。
Abstract:
Objective To study HIV infection in tuberculosis (TB) patients in rural areas of Nanning city in order to provide scientific basis for the prevention and treatment in the future.Methods From 2015 to 2017, HIV antibody screening was carried in new registered TB patients in the county tuberculosis clinics, and HIV positive samples were further verified by the municipal disease prevention and control center.Epidemiological methods were used to analyze the demographic characteristics of HIV infection.ResultsOut of 5 031 registered TB patients, 4 444 cases (88.33%) received HIV antibody screen. A total of 29 patients (0.65%) were HIV antibody-positive.The highest positive rate was found in LA county (1.11%).HIV infection rates did not differ significantly either among the years (χ2=5.493, P>0.05) or the counties (χ2=4.752, P>0.05).Co-infections of TB/HIV were mainly transmitted by heterosexual contact.Logistic regression analysis showed that the risk factors of co-infections of TB/HIV were patients′ aged ≥50 years (OR=2.823,95%CI: 1.332~5.991) and treatment outcome of death (OR=7.832,95%CI: 3.951~7.817).On the other hand, females displayed lower rate of TB/HIV co-infections (OR=0.661,95%CI: 0.588~0.744).ConclusionThe HIV infection rate in TB patients is at medium level in rural areas of Nanning.Prevention and treatment of TB/HIV co-infection should be focused on males ≥50 years of age.Management approaches of TB/HIV co-infection include routine HIV screening, public health education, monitoring, earlier diagnosis and intervention of TB and HIV infections.

参考文献/References:


[1]王冬梅,李涛,周林,等.在中国新登记的结核病病人中开展HIV筛查策略的论证[J].中国艾滋病性病,2013,19(4):297-300.
[2] 李涛,成诗明,杜昕,等.对Mtb与HIV双重感染防治重点县(区)结核病患者进行HIV检测的效果分析[J].中国防痨杂志,2013,35(11):905-909.
[3] 梁大斌,林玫,崔哲哲,等.2014-2016年广西结核杆菌/艾滋病病毒双重感染监测结果分析[J].现代预防医学,2017, 44(14): 2628-2631.
[4] 要玉霞,甄新安,赵富山.河南省六县结核病患者中HIV感染筛查结果分析[J].中国防痨杂志,2013,35(6): 477-479.
[5] World Health Organization.Global tuberculosis control 2014[R].Geneva,2014.
[6] 袁薇,雷世光,陈慧娟,等.贵州省结核病和艾滋病双向筛查4年监测结果分析[J].中国卫生检验杂志,2015,25(13):2202-2206.
[7] 崔哲哲,林玫,蓝如束,等.症状筛查与影像学检查在结核杆菌/艾滋病病毒双重感染监测中的应用评价[J].现代预防医学,2017,44(11):2071-2075.
[8] Liang S, Shen Z, Yan J, et al.Low virologic failure and drug resistance among HIV-infected patients receiving Hospital-Based ART while care and outreach through community in Guangxi, China[J].Front Public Health, 2015, 3: 244.
[9] 陈阳贵,陆娟,马丽,等.乌鲁木齐市结核病患者中HIV感染状况调查[J].现代预防医学,2012,39(20):5410-5412.
[10] 李浩,汤晓斌,杨晓钊,等.2010-2012年南宁市老年人群艾滋病病例报告特征分析[J].职业卫生与病伤,2016 ,31(6):391-394.
[11] Gao L,Zhou F,Li XW, et al.HIV/TB Co-infection in mainland China:a Meta-Analysis[J].PLoS One,2010,5(5):e10736.
[12] 谢祎,李静,马平安,等.天津市结核病患者HIV感染现状调查[J].现代预防医学,2015, 42(8):1501-1504.
[13] 李斯斯,林新勤,徐永芳,等.1989-2014 年南宁市医疗卫生机构艾滋病报告病例回顾性分析[J].中国皮肤性病学杂志,2016,30(2):157-159.
[14] 覃春伟,李晓华,覃雄林,等.低档场所≥50岁老年男性嫖客HIV/梅毒感染及影响因素分析[J].现代预防医学,2015,42(5):864-867.

相似文献/References:

[1]孙小华,李学平,孟淑娟.庆阳市2012-2014年艾滋病自愿咨询检测情况分析[J].中国皮肤性病学杂志,2016,(05):487.[doi:10.13735/j.cjdv.1001-7089.201504037]
 SUN Xiao hua,LI Xue ping,MENG Shu juan.Analysis of HIV Voluntary Counseling and Testing Situation in Qingyang City from 2012 to 2014[J].The Chinese Journal of Dermatovenereology,2016,(05):487.[doi:10.13735/j.cjdv.1001-7089.201504037]
[2]路新利,赵宏儒,张玉琪,等.高效抗病毒治疗后病毒学失败的儿童艾滋病29例HIV-1基因突变和耐药分析[J].中国皮肤性病学杂志,2014,(10):1035.[doi:10.13735/j.cjdv.1001-7089.2014.1035]
 LU Xin-li,ZHAO Hong-ru,ZHANG Yu-qi,et al.Analyzing of HIV-1 Drug resistance And Gene Mutation Among 29 Children with Virological Failure after Highly Active Anti-retroviral Therapy(HAART)[J].The Chinese Journal of Dermatovenereology,2014,(05):1035.[doi:10.13735/j.cjdv.1001-7089.2014.1035]
[3]刘丹,刘艳,岳军,等.结核病患者3 545例梅毒血清学抗体试验结果分析[J].中国皮肤性病学杂志,2014,(07):716.[doi:10.13735/j.cjdv.10017089.2014.0716]
 LIU Dan,LIU Yan,YUE Jun,et al.Analysis of Serological Test Results for Syphilis Antibody of 3 545 Patients with Tuberculosis[J].The Chinese Journal of Dermatovenereology,2014,(05):716.[doi:10.13735/j.cjdv.10017089.2014.0716]

备注/Memo

备注/Memo:
[基金项目]广西卫生和计划生育委员会科研课题(Z20180347);广西卫生和计划生育委员会科研课题(Z20181042);南宁市科技局科研课题(20163112)
[作者单位]广西南宁市疾病预防控制中心,广西 南宁530023
更新日期/Last Update: 2019-04-15