[1]梁妮,黎炜,杨艳平,等.马拉色菌毛囊炎154例临床特点与病理观察[J].中国皮肤性病学杂志,2019,(05):534-537.[doi:10.13735/j.cjdv.1001-7089.201707002]
 LIANG Ni,LI Wei,YANG Yanping,et al.Clinical Features and Pathological Observation of Malassezia Folliculitis in 154 Cases[J].The Chinese Journal of Dermatovenereology,2019,(05):534-537.[doi:10.13735/j.cjdv.1001-7089.201707002]
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马拉色菌毛囊炎154例临床特点与病理观察
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2019年05期
页码:
534-537
栏目:
临床经验
出版日期:
2019-04-01

文章信息/Info

Title:
Clinical Features and Pathological Observation of Malassezia Folliculitis in 154 Cases
文章编号:
1001-7089(2019)05-0534-04
作者:
梁妮黎炜杨艳平黎世杰李文王洁娣樊翌明
广东医科大学附属医院皮肤科,广东湛江524001
Author(s):
LIANG Ni LI Wei YANG Yanping LI Shijie LI Wen WANG Jiedi FAN Yiming
(Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China)
关键词:
马拉色菌毛囊炎马拉色菌黏蛋白
Keywords:
Malassezia folliculitisMalasseziaMucin
分类号:
R 753.3
DOI:
10.13735/j.cjdv.1001-7089.201707002
文献标志码:
B
摘要:
目的总结马拉色菌毛囊炎(MF)临床病理特点。方法采用自行设计调查表收集154例马拉色菌毛囊炎患者临床资料,其中23例行组织病理检查。结果154例马拉色菌毛囊炎患者中男女之比为6.3∶1,平均年龄、病程分别为20.3岁、12.4个月;皮损主要为红色毛囊性丘疹(96.75%)、丘脓疱疹(65.58%),常见于背部(89.61%)、胸部(71.43%)。23例皮损活检标本中,苏木素-伊红染色显示表皮棘层肥厚(86.96%)、海绵形成(78.26%)、毛囊口角质栓(82.61%)、毛囊扩张和(或)破裂伴毛囊周围炎症细胞浸润(100.00%);阿辛蓝-过碘酸雪夫(AB-PAS)染色发现紫红色孢子16例(69.57%)、黏蛋白沉积5例(21.74%)。结论马拉色菌毛囊炎好发于青少年男性,皮损主要累及胸背部;主要病理特点是毛囊口角质栓、毛囊扩张和(或)破裂、毛囊周围炎症细胞浸润、酵母样孢子。在MF皮损病理检查时,建议用AB-PAS染色同时显示皮损中黏蛋白和孢子。
Abstract:
Objective To summarize the clinicopathological features of Malassezia folliculitis (MF).MethodsClinical data of 154 patients with MF were collected with self-designed questionnaire, of which 23 cases underwent histopathological examination.ResultsOf 154 cases, the male/female ratio was 6.3∶1, and mean age and duration were 20.3 years and 12.4 months, respectively.The typical lesions were erythematous follicular papules (96.75%) and papulopustules (65.58%), mainly located on the back (89.61%) and chest (71.43%).of 23 skin biopsies, hematoxylin-eosin stain showed epidermal acanthosis (86.96%), spongiosis (78.26%), keratinous plug of the follicular ostium (82.61%), follicular dilation and/or rupture with perifollicular inflammatory infiltrate (100.00%).Alcian blue and periodic acid-Schiff (AB-PAS) stain revealed purple spores in 16 cases (69.57%) and mucin deposition in 5 cases (21.74%).ConclusionMF is more common in male teenagers, and often affects the back and chest.The main pathological features include keratinous plug of the follicular orifice, follicular dilation and/or rupture, perifollicular inflammatory infiltrate, and yeastlike spores.AB-PAS stain can be used to observe both mucin and spores in skin lesion during pathologic examination of MF.

参考文献/References:


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备注/Memo

备注/Memo:
[基金项目]国家自然科学基金项目(81673071);广东省医学科学技术研究基金项目(A2017413)
[作者单位]广东医科大学附属医院皮肤科,广东湛江524001
[通讯作者]樊翌明,E-mail:ymfan1963@163.com
更新日期/Last Update: 2019-04-15