[1]吴静,王培光,孙良丹.以网状青斑为皮损表现的新生儿红斑狼疮1例及文献复习[J].中国皮肤性病学杂志,2018,(08):919-921.[doi:10.13735/j.cjdv.1001-7089.201711060]
 WU Jing,WANG Peiguang,SUN Liangdan.A Case of Neonatal Lupus Erythematosus Manifested as Livedo Reticularis and Literature Review[J].The Chinese Journal of Dermatovenereology,2018,(08):919-921.[doi:10.13735/j.cjdv.1001-7089.201711060]
点击复制

以网状青斑为皮损表现的新生儿红斑狼疮1例及文献复习
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2018年08期
页码:
919-921
栏目:
病例报告
出版日期:
2018-09-10

文章信息/Info

Title:
A Case of Neonatal Lupus Erythematosus Manifested as Livedo Reticularis and Literature Review
作者:
吴静1王培光1孙良丹12
1.安徽医科大学皮肤病研究所,安徽医科大学第一附属医院皮肤性病科,安徽 合肥 230032; 2.重大自身免疫性疾病安徽省重点实验室,安徽 合肥 230032
Author(s):
WU Jing1WANG Peiguang1SUN Liangdan12
1.Institute of Dermatology & Department of Dermatology,the First Affiliated Hospital in Anhui Medical University,Hefei 230032,China; 2.Anhui Province Key Laboratory of Major Autoimmune Disease,Hefei 230032,China
关键词:
红斑狼疮新生儿 网状青斑
Keywords:
NLE Reticulate
分类号:
R 593.24
DOI:
10.13735/j.cjdv.1001-7089.201711060
文献标志码:
B
摘要:
患儿男,3个月,全身紫红色斑3个月。患儿母亲孕前确诊为系统性红斑狼疮,一直口服泼尼松及羟氯喹治疗。皮肤科情况:全身弥漫性网状紫红色斑疹,以面部和躯干为著。抗核抗体十三项:ANA(+)(1:3 200),抗SS-A(52)抗体(+),抗SS-A(60)抗体(+)。肝功能:ALT 252U/L,AST 173U/L,LDH 293U/L。诊断:新生儿红斑狼疮,肝功能异常。予以还原型谷胱甘肽及复方甘草酸苷二联保肝治疗1周后,患儿病情好转。
Abstract:
A 3-month-old male infant presented with generalized purple rashes for 3 months. His mother was diagnosed as systemic lupus erythematosus before pregnancy,and treated with oral prednisone and hydroxychloroquine. Physical examination revealed diffuse reticular purple macules on his whole body,especially in his face and trunk. Anti-nuclear antibody examination showed positive ANA with titer 1:3 200,anti-SS-A(52)antibody and anti-SS-A(60)antibody. Liver function test showed ALT 252U/L,AST 173U/L and LDH 293U/L. The diagnosis of neonatal lupus erythematosus(NLE)with abnormal liver function was made. The health condition had been improved after the infant was treated with reductive glutathione and compound glycyrrhizin for one week.

参考文献/References:


[1] Zuppa AA,Riccardi R,Frezza S,et al.Neonatal lupus:Follow-up in infants with anti-SSA/Ro antibodies and review ofthe literature[J].Autoimmun Rev,2017,16(4):427-432.
[2] Yu Y,Du L,Pan J,et al.A 10-year retrospective study of neonatal lupus erythematous in China[J].Asian Pac J Allergy Immunol,2016,34(2):174-178.
[3] Li YQ,Wang Q,Luo Y,et al.Neonatal lupus erythematosus: a review of 123 cases in China[J].Int J Rheum Dis,2015,18(7):761-767.
[4] Boh EE.Neonatal lupus erythematosus[J].Clin Dermatol,2004,22(2):125-128.
[5] Lee LA.Cutaneous lupus in infancy and childhood[J].Lupus,2010,19(9):1112-1117.
[6] 刘萍.网状青斑1例[J].皮肤病与性病,2014,37(2):117.
[7] 冯素英,靳培英,李安生.抗心磷脂抗体和免疫异常在青斑样血管炎中的意义[J].中国皮肤性病学杂志,2008,22(12):705-706.
[8] Lateef A,Petri M.Systemic lupus erythematosus and pregnancy[J].Rheum Dis Clin North Am,2017,43(2):215-226.
[9] Knight CL,Nelson-Piercy C.Management of systemic lupus erythematosus during pregnancy: challenges and solutions[J].Open Access Rheumatol,2017,9:37-53.
[10] Barsalou J,Jaeggi E,Laskin CA,et al.Prenatal exposure to antimalarials decreases the risk of cardiac but not non-cardiac neonatal lupus: a single-centre cohort study[J].Rheumatology(Oxford),2017,56(9):1552-1559.
[11] Heughan CE,Kanigsberg N.Cutis marmorata telangiectatica congenita and neonatal lupus[J].Pediatr Dermatol,2007,24(3):320-321.
[12] Del Boz J,Serrano Mdel M,Gomez E,et al.Neonatal lupus erythematosus and cutis marmorata telangiectatica congenita-like lesions[J].Int J Dermatol,2009,48(11):1206-1208.
[13] Trevisan F,Cunha PR,Pinto CA,et al.Cutaneous neonatal lupus with cutis marmorata telangiectatica congenita-like lesions[J].An Bras Dermatol,2013,88(3):428-431.

相似文献/References:

[1]凡慧,王继辉,范萍,等.滋阴清热药对狼疮鼠肾组织自噬基因atg16L1和细胞焦亡炎症因子的影响[J].中国皮肤性病学杂志,2017,(06):602.[doi:10.13735/j.cjdv.1001-7089.201611152]
 FAN Hui,WANG Ji-hui,FAN Ping,et al.Effects on Autophagy Gene atg16L1 and Pyroptosis Immune Inflammatory Factors in Nephridial Tissue of Lupus Mice with Nourishing Yin Clearing Heat Herbs[J].The Chinese Journal of Dermatovenereology,2017,(08):602.[doi:10.13735/j.cjdv.1001-7089.201611152]
[2]王小云,尹光文,张华.误诊为线状IgA大疱性皮病的大疱性系统性红斑狼疮1例[J].中国皮肤性病学杂志,2018,(02):200.[doi:10.13735/j.cjdv.1001-7089.201705072]
 WANG Xiaoyun,YIN Guangwen,ZHANG Hua.A Case of Bulloussystemic Lupus Erythematosus Misdiagnosed as Linear IgA Bullous Dermatosis[J].The Chinese Journal of Dermatovenereology,2018,(08):200.[doi:10.13735/j.cjdv.1001-7089.201705072]
[3]王文欢,王红梅.表观遗传学在系统性硬皮病和系统性红斑狼疮中的研究状况[J].中国皮肤性病学杂志,2018,(03):341.[doi:10.13735/j.cjdv.1001-7089.201608134]
 WANG Wenhuan,WANG Hongmei.Epigenetic in the Autoimmune Skin Diseases[J].The Chinese Journal of Dermatovenereology,2018,(08):341.[doi:10.13735/j.cjdv.1001-7089.201608134]
[4]刘慧敏,张瑞英,姚贵申.SLE患者并发院内感染220例的临床特点及易感因素分析[J].中国皮肤性病学杂志,2013,(10):42.
 LIU Hui-min,ZHANG Rui-ying,YAO Gui-shen.Analysis of Predisposing Factors and Clinical Characteristics of 220Patients with Systemic Lupus Erythematosus Accomparied by Infection[J].The Chinese Journal of Dermatovenereology,2013,(08):42.
[5]徐文英.紫外线与红斑狼疮关系的分子、细胞水平研究进展[J].中国皮肤性病学杂志,2014,(03):307.
 XU Wen-ying.Advance in the Molecular and Cellular Research of Ultraviolet on Lupus Erythematosus[J].The Chinese Journal of Dermatovenereology,2014,(08):307.
[6]张红爱,张娟利,于淑群,等.新生儿色素失禁症7例临床分析[J].中国皮肤性病学杂志,2014,(02):145.
 ZHANG Hongai,ZHANG Juanli,YU Shuqun,et al.Clinical Analysis of Incontinentia Pigmenti in 7 Cases with Neonates[J].The Chinese Journal of Dermatovenereology,2014,(08):145.
[7]边鹊桥.新生儿皮肤再生不良1例[J].中国皮肤性病学杂志,2014,(02):190.
 BIAN Queqiao.One Case of Neonatal Skin Aplasia[J].The Chinese Journal of Dermatovenereology,2014,(08):190.
[8]李咏梅.新生儿红斑狼疮18例临床分析[J].中国皮肤性病学杂志,2014,(05):476.[doi:10.13735/j.cjdv.10017089.2014.0476]
 LI Yongmei.Neonatal Lupus Erythematosus: Clinical Analysis of 18 Cases[J].The Chinese Journal of Dermatovenereology,2014,(08):476.[doi:10.13735/j.cjdv.10017089.2014.0476]
[9]曾世华,周培媚,路永红,等.妊娠瘙痒性荨麻疹性丘疹和斑块32例危险因素及对胎儿的影响[J].中国皮肤性病学杂志,2014,(05):480.[doi:10.13735/j.cjdv.10017089.2014.0480]
 ZENG ShiHua,ZHOU PeiMei,LU YongHong,et al.Risk Factors and Effects on Fetus of 32 Cases with Pruritic Urticarial Papules and Plaques of Pregnancy[J].The Chinese Journal of Dermatovenereology,2014,(08):480.[doi:10.13735/j.cjdv.10017089.2014.0480]
[10]孙乐栋,郭云龙,刘雪艳,等.同时高效去除动员SLE患者外周血造血干细胞中T/B细胞[J].中国皮肤性病学杂志,2013,(03):237.
[11]徐平,王威,陈晓霞,等.新生儿红斑狼疮4例临床分析并文献复习[J].中国皮肤性病学杂志,2017,(07):751.[doi:10.13735/j.cjdv.1001-7089.201611005]
 XU Ping,WANG Wei,CHEN Xiao-xia,et al.Neonatal Lupus Erythematosus: Report of Four Cases and Literature Review[J].The Chinese Journal of Dermatovenereology,2017,(08):751.[doi:10.13735/j.cjdv.1001-7089.201611005]

备注/Memo

备注/Memo:
[基金项目] 国家万人计划青年拔尖人才项目
[作者单位] 1.安徽医科大学皮肤病研究所,安徽医科大学第一附属医院皮肤性病科,安徽 合肥 230032; 2.重大自身免疫性疾病安徽省重点实验室,安徽 合肥 230032
[通讯作者] 孙良丹,E-mail:ahmusld@163.com
更新日期/Last Update: 2018-08-01