[1]黄敖,罗宏,张莲,等.5-氨基酮戊酸光动力疗法治疗尖锐湿疣合并HIV感染25例疗效观察[J].中国皮肤性病学杂志,2018,(06):733-736.[doi:10.13735/j.cjdv.1001-7089.201710070]
　HUANG Ao,LUO Hong,ZHANG Lian,et al.Effect of Photodynamic Therapy on Condyloma Acuminata Combined with HIV for 25 Patients[J].The Chinese Journal of Dermatovenereology,2018,(06):733-736.[doi:10.13735/j.cjdv.1001-7089.201710070]
点击复制

5-氨基酮戊酸光动力疗法治疗尖锐湿疣合并HIV感染25例疗效观察
分享到：

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2018年06期
页码:
733-736
栏目:
药物与临床
出版日期:
2018-06-01

文章信息/Info

Title:
Effect of Photodynamic Therapy on Condyloma Acuminata Combined with HIV for 25 Patients
作者:
黄敖; 罗宏; 张莲; 何莹; 谭紫夷
长沙市第一医院皮肤性病科,湖南 长沙 410000
Author(s):
HUANG Ao;  LUO Hong;  ZHANG Lian;  HE Ying;  TAN Ziyi
Department of Dermatology,Changsha First Hospital,Changsha 410000,China
关键词:
尖锐湿疣;  人类免疫缺陷病毒;  光动力疗法
Keywords:
Condyloma acuminatum;  Human immunodeficiency virus;  Photodynamic therapy
分类号:
R 752.5+3; R 512.91
DOI:
10.13735/j.cjdv.1001-7089.201710070
文献标志码:
A
摘要:
目的 探讨光动力疗法治疗合并HIV感染的尖锐湿疣的治疗效果。方法 选择50例合并HIV感染的尖锐湿疣患者为研究对象,采用随机分组法将50例患者分为对照组(25例)与研究组(25例)。对照组中疣体直径≤5mm者给予局部使用咪喹莫特乳膏治疗,疣体直径>5mm者先用CO2激光灼烧疣体再用咪喹莫特乳膏治疗; 研究组中疣体直径≤5mm者给予光动力学治疗,疣体直径>5mm者先用CO2激光灼烧疣体再给予光动力治疗。完成各组3次疗程并随访半年,比较两组患者尖锐湿疣的治愈、复发情况以及各组的不良反应。结果 研究组较对照组具有较高的治愈率以及较少并发局部皮肤、黏膜的损伤,差异有统计学意义(P<0.05),两组间患者局部皮肤、黏膜的疼痛情况差异有统计学意义(P<0.05),研究组患者疼痛程度较高。结论 光动力疗法治疗合并HIV感染的尖锐湿疣虽局部疼痛较明显但具有较好疗效,皮肤黏膜的损伤小。
Abstract:
Objective To explore the therapeutic effect of photodynamic therapy on condyloma acuminatum combined with HIV. Methods Fifty cases of condyloma acuminatum with HIV were selected and divided into control group(25 cases)and study group(25 cases)by random grouping method. Patients who had the wart diameter no more than 5mm were treated topically with etomidate and miconazole cream in the control group. As the wart diameter was more than 5mm the treatment started with CO2 laser and followed with etomidate and miconazole cream. In the study group, the treatment of photodynamic therapy was used to the patients whose wart diameter was less than 5mm, while for the wart diameter larger than 5mm the treatment had additional CO2 laser to burn the wart body in the first step. The treatment completed with three courses in each group and the follow-up last six months. During the period the therapeutic effect, recurrence and adverse reactions in each group were compared. Results Compared with the control group, the study group had a higher cure rate and less complication of local skin and mucous membrane, and the difference was statistically significant(P<0.05). The pain of the topical skin and mucous membrane was statistically different(P<0.05), and the patients in the study group had a higher degree of pain. Conclusion Photodynamic therapy is effective in treating condyloma acuminatum with HIV, and the injury of skin mucosa is slight, but topical pain is obvious.

参考文献/References:

[1] 任荣鑫,米霞,李军,等. 尖锐湿疣患者合并宫颈高危型HPV感染的光动力治疗[J].中国艾滋病性病,2014, 20(4):266-268.
[2] 中国疾病预防控制中心性病控制中心.性传播疾病临床诊疗指南[M]. 2006,(7):17-18.
[3] Buchness MR. Treatment of skin diseases in HIV-infected patients[J]. Dermatol Clin, 1995, 13(1):231-238.
[4] 程鸽,李娟,叶江竹,等.微波联合5-盐酸氨酮戊酸光动力治疗肛内尖锐湿疣合并HIV感染的疗效观察[J].中国艾滋病性病,2016, 22(6): 471-472.
[5] 徐城,杨晓秋,刘丹彦. 常用的疼痛评估方法在临床疼痛评估中的作用[J]. 中国疼痛医学杂志,2015,21(3): 210-212.
[6] 黄海静,吴冬玲,伦文辉,等. 艾滋病合并直肠内尖锐湿疣患者的光动力治疗体会[J].中国艾滋病性病,2010, 16(5):513-514.
[7] 田娜.痔疮合并尖锐湿疣光动力治疗及围术期护理[J]. 中国地方病防治杂志,2014,S1:289-299.
[8] 王夏青,王晓霞,李轶雯,等. ALA光动力联合中药保留灌肠治疗AIDS合并肛管尖锐湿疣临床观察[J].中国艾滋病性病,2017, 23(1):73-75.
[9] 杨宇光,张云杰,邹先彪. ALA-光动力疗法治疗妊娠合并尖锐湿疣[J]. 中国激光医学杂志,2013,21(5):78-79.
[10] 王远清,游明芝. 5-氨基酮戊酸光动力疗法联合CO2激光治疗尖锐湿疣的疗效观察[J].当代医学,2011,17(11): 31-32.

相似文献/References:

[1]徐顺明,谭娟,曹艳云,等.基因芯片对男性不同部位尖锐湿疣皮损中HPV型别的检测[J].中国皮肤性病学杂志,2012,(08):713.
　XU Shun-ming,TAN Juan,CAO Yan-yun,et al.Detection and Analyze of Male Condylomata Acuminata Lesions from Different Anatomical Locations with Human Papillomavirus Genotypes Gene Chips[J].The Chinese Journal of Dermatovenereology,2012,(06):713.
[2]肖汉龙,陶娟,王育珏,等.尖锐湿疣组织中HIF-1α,VEGF的表达及其与血管生成的关系[J].中国皮肤性病学杂志,2012,(08):717.
　XIAO Han-long,TAO Juan,WANG Yu-jue,et al.Relationship of the Expression of HIF-1α and VEGF with Angiogenesis in Condyloma Acuminatum[J].The Chinese Journal of Dermatovenereology,2012,(06):717.
[3]孙卫国,江明,张素玲.光动力疗法联合改性几丁质治疗尖锐湿疣疗效及HPV基因型分析[J].中国皮肤性病学杂志,2015,(01):53.[doi:10.13735/j.cjdv.1001-7089.2015.0053]
　SUN Wei guo,JIANG Ming,ZHANG Su ling.Photodynamic Therapy Combined with Modified Chitin in Treating Condyloma Acuminatum and HPV Genotype Followup[J].The Chinese Journal of Dermatovenereology,2015,(06):53.[doi:10.13735/j.cjdv.1001-7089.2015.0053]
[4]唐正东.咪喹莫特乳膏联合氩气高频电刀治疗尖锐湿疣44例临床观察[J].中国皮肤性病学杂志,2015,(04):385.[doi:10.13735/j.cjdv.1001-7089.201406166]
　TANG Zheng dong.Clinical Observation of Imiquimod Cream Combined with Argon Highfrequency Electrotome in 44 Patients with Condyloma Acuminatum[J].The Chinese Journal of Dermatovenereology,2015,(06):385.[doi:10.13735/j.cjdv.1001-7089.201406166]
[5]林晓晖.黄甘颗粒对CA患者血清IFN-γ,IL-2水平的影响及其抑制CA复发效果评价[J].中国皮肤性病学杂志,2015,(06):595.[doi:10.13735/j.cjdv.1001-7089.201409057]
　LIN Xiao hui.Effects of the Huanggan Granules on Serum IFNγ and IL2 Levels, and its Inhibition on the Recurrence of CA[J].The Chinese Journal of Dermatovenereology,2015,(06):595.[doi:10.13735/j.cjdv.1001-7089.201409057]
[6]刘坤鹏,李卫红,范团起.剪除疣体联合CO2激光治疗尖锐湿疣59例临床观察[J].中国皮肤性病学杂志,2015,(06):606.[doi:10.13735/j.cjdv.1001-7089.201410140]
　LIU Kun peng,LI Wei hong,FAN Tuan qi.The Efficacy of Cutting off CA with Scissors Plus CO2 Laser for treating 59 Cases of Condyloma Acuminatum[J].The Chinese Journal of Dermatovenereology,2015,(06):606.[doi:10.13735/j.cjdv.1001-7089.201410140]
[7]周冼苡䥺Symbol`@@,杨烨玫,周思彤.微波联合光动力疗法治疗系统性红斑狼疮并尖锐湿疣1例[J].中国皮肤性病学杂志,2015,(06):608.[doi:10.13735/j.cjdv.1001-7089.201411120]
　ZHOU Xian yi,YANG Ye mei,ZHOU Si tong.Microwave Combined with Photodynamics for Condyloma Acuminatum in Patient with Systemic Lupus Erythematosus Patient: a Case Report[J].The Chinese Journal of Dermatovenereology,2015,(06):608.[doi:10.13735/j.cjdv.1001-7089.201411120]
[8]荚琳琳,季必华.儿童常见性病的临床特点[J].中国皮肤性病学杂志,2015,(07):743.[doi:10.13735/j.cjdv.1001-7089.201409165]
　JIA Lin lin,JI Bi hua.Clinical Characteristics of Common Sexually Transmitted Diseases in Children[J].The Chinese Journal of Dermatovenereology,2015,(06):743.[doi:10.13735/j.cjdv.1001-7089.201409165]
[9]江从军,金慧玲.光动力疗法和咪喹莫特预防老年男性尖锐湿疣复发的疗效观察[J].中国皮肤性病学杂志,2015,(08):823.[doi:10.13735/j.cjdv.1001-7089.201412062]
　JIANG Cong jun,JIN Hui ling.Comparision of Therapeutic Effect of Photodynamic Therapy and Imiquimod in Recurrence Prevention of Condylomata Acuminata in Senile Male Patients after Treatment with Microwave[J].The Chinese Journal of Dermatovenereology,2015,(06):823.[doi:10.13735/j.cjdv.1001-7089.201412062]
[10]周艳,张志灵,韩丹,等.尖锐湿疣患者复发因素的临床分析[J].中国皮肤性病学杂志,2015,(09):936.[doi:10.13735/j.cjdv.1001-7089.201411145]
　ZHOU Yan,ZHANG Zhi ling,HAN Dan,et al.Analysis Research of Clinical Data for Recurrence Factor of Condyloma Acuminatum[J].The Chinese Journal of Dermatovenereology,2015,(06):936.[doi:10.13735/j.cjdv.1001-7089.201411145]

备注/Memo

备注/Memo:
[通讯作者] 罗宏,E-mail:lhdoctor@yeah.net
更新日期/Last Update: 2018-06-01