[1]薛紫,唐旭华,王芳,等.前额纤维性脱发7例的临床特征及文献回顾[J].中国皮肤性病学杂志,2018,(05):523-528.[doi:10.13735/j.cjdv.1001-7089.201707125]
 XUE Zi,TANG Xuhua,WANG Fang,et al.The Clinical Features of Frontal Fibrosing Alopecia: A Review of 7 Cases[J].The Chinese Journal of Dermatovenereology,2018,(05):523-528.[doi:10.13735/j.cjdv.1001-7089.201707125]
点击复制

前额纤维性脱发7例的临床特征及文献回顾
分享到:

《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2018年05期
页码:
523-528
栏目:
临床经验
出版日期:
2018-05-01

文章信息/Info

Title:
The Clinical Features of Frontal Fibrosing Alopecia: A Review of 7 Cases
作者:
薛紫唐旭华王芳叶艳婷杨建章星琪
中山大学附属第一医院皮肤性病科, 广东 广州 510080
Author(s):
XUE Zi TANG Xuhua WANG Fang YE Yanting YANG Jian ZHANG Xingqi
Department of Dermatology and Venereology, the First Affiliated Hospital, Sun Yet-sun University, Guangzhou 510080, China
关键词:
前额纤维性脱发 临床表现 诊断 治疗
Keywords:
Frontal fibrosing alopecia Clinical features Diagnose Treatment
分类号:
R 758.71
DOI:
10.13735/j.cjdv.1001-7089.201707125
文献标志码:
B
摘要:
目的 探讨前额纤维性脱发患者的临床表现、皮肤镜下特征、病理特点及疗效。方法 收集本院毛发专科门诊2014年12月1日-2016年10月1日前额纤维性脱发患者7例,回顾分析其流行病学资料、临床表现、皮肤镜表现、病理特点及治疗效果。结果 7例患者均为女性,发病年龄19~54岁。所有患者均有前额、颞部发际线后退表现,眉毛脱失似与绝经相关。皮肤镜下,所有患者均有毛囊口消失、毛周红斑的征象,3例具有毛周角化。5例病理均提示毛囊周围淋巴细胞浸润伴纤维增生,5例患者接受口服羟氯喹、甲泼尼龙,外用卤米松或0.1%他克莫司乳膏治疗,其发际线后退速度减慢或停止。结论 前额纤维性脱发为前额和颞部发际线处的瘢痕性脱发,好发于绝经期女性,亦可侵及眉毛和腋毛,治疗不能导致毛囊的再生,但可减缓病情进展。
Abstract:
Objective To describe the clinical and dermoscopic features, and the response to treatment in patients with frontal fibrosing alopecia(FFA)in China. Methods Data analysis from case notes, which included epidemiological information, clinical manifestation, dermoscopic features, histopathology and response to treatment, was performed on seven patients with a diagnosis of FFA presenting to Outpatient Department of our hospital from December 2014 to October 2016. Results All patients in this cohort were females, with age at onset of between 19 and 54 years. All patients had recession of frontal and temporal hairline. All postmenopausal patients had complete or partial loss of eyebrows. Dermoscopic features included disapearance of follicular ostia and presence of perifollicular erythema in all patients, and perifollicular hyperkeratosis in 3. Biopsy of five patients revealed lymphocytic infiltration with perifollicular fibrosis. After treatment with oral hydroxychloroquine, methylprednisolone, compound glycyrrhizin and topical halometasone cream or 0.1% tacrolimus cream, their frontal hairline recession were slowed down or stable as a response to the treatment. Conclusion FFA is a kind of cicatricial alopecia which typically affects postmenopausal women, with typical features of recession of frontal and temporal hairline, complete or partial loss of eyebrows or hircus. Corresponding treatment may contribute to slow recession of hairline other than regeneration of hair follicles.

参考文献/References:

[1] Kossard S. Postmenopausal frontal fibrosing alopecia.Scarring alopecia in a pattern distribution[J]. Arch Dermatol, 1994, 130(11): 770-774.
[2] Harries MJ, Meyer K, Chaudhry I, et al. Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche[J]. J Pathol, 2013, 231(2):236-247.
[3] Tosti A, Piraccini BM, Iorizzo M, et al. Frontal fibrosing alopecia in postmenopausal women[J]. J Am Acad Dermatol, 2005, 52(1):55-60.
[4] Tan KT, Messenger AG. Frontal fibrosing alopecia: clinical presentations and prognosis[J]. Br J Dermatol, 2009,160(1):75-79.
[5] Georgala S, Katoulis AC, Befon A, et al. Treatment of postmenopausal frontal fibrosing alopecia with oral dutasteride[J]. J Am Acad Dermatol, 2009, 61(1):157-158.
[6] Chiang C, Sah D, Cho BK, et al. Hydroxychloroquine and lichen planopilaris: efficacy and introduction of Lichen Planopilaris Activity Index scoring system[J]. J Am Acad Dermatol, 2010, 62(3):387-392.
[7] Harries MJ, Meyer KC, Chaudhry IH, et al. Does collapse of immune privilege in the hair-follicle bulge play a role in the pathogenesis of primary cicatricial alopecia[J]. Clin Exp Dermatol, 2010, 35(6):637-644.
[8] Ladizinski B, Bazakas A, Selim MA, et al.Frontal fibrosing alopecia: a retrospective review of 19 patients seen at Duke University[J]. J Am Acad Dermatol, 2013, 68(5):749-755.
[9] Holmes S. Frontal fibrosing alopecia[J]. Skin Therapy Lett, 2016, 21(4):5-7.
[10] Alegre-Sánchez A, Saceda-Corralo D, Bernárdez C, et al. Frontal fibrosing alopecia in male patients: a report of 12 cases[J]. J Eur Acad Dermatol Venereol, 2017, 31(2):e112-e114.
[11] Ormaechea-Pérez N, López-Pestaña A, Zubizarreta-Salvador J, et al. Frontal fibrosing alopecia in men: presentations in 12 cases and a review of the literature[J]. Actas Dermosifiliogr, 2016, 107(10):836-844.
[12] Atarguine H, Hocar O, Hamdaoui A, et al. Frontal fibrosing alopecia: Report on three pediatric cases[J]. Arch Pediatr, 2016, 23(8):832-835.
[13] Georgala S, Katoulis AC, Befon A, et al. Treatment of postmenopausal frontal fibrosing alopecia with oral dutasteride[J]. J Am Acad Dermatol, 2009, 61(1):157-158.
[14] Katoulis A, Georgala S, Bozi E, et al. Frontal fibrosing alopecia: Treatment with oral dutasteride and topical pimecrolimus[J]. J Eur Acad Dermatol Venereol, 2009, 23(5):580-582.
[15] Dlova N, Goh CL, Tosti A. Familial frontal fibrosing alopecia[J]. Br J Dermatol, 2013, 168(1): 220-222.
[16] Navarro-Belmonte MR, Navarro-López V, Ramírez-Boscà A, et al. Case series of familial frontal fibrosing alopecia and a review of the literature[J]. J Cosmet Dermatol, 2015, 14(1):64-69.
[17] Junqueira Ribeiro Pereira AF, Vincenzi C, Tosti A. Frontal fibrosing alopecia in two sisters[J]. Br J Dermatol, 2010, 162(5):1154-1155.
[18] MacDonald A, Clark C, Holmes S. Frontal fibrosing alopecia: A review of 60 cases[J]. J Am Acad Dermatol, 2012, 67(5):955-961.
[19] Ladizinski B, Bazakas A, Selim MA, et al. Frontal fibrosing alopecia: A retrospective review of 19 patients seen at Duke University[J]. J Am Acad Dermatol, 2013, 68(5):749-755.
[20] Banka N, Mubki T, Bunagan MJ, et al. Frontal fibrosing alopecia: a retrospective clinical review of 62 patients with treatment outcome and long-term follow-up[J]. Int J Dermatol, 2014, 53(11): 1324-1330.
[21] Samrao A, Chew AL, Price V. Frontal fibrosing alopecia: a clinical review of 36 patients[J]. Br J Dermatol, 2010, 163(6):1296-1300.
[22] Moreno-Ramírez D, Camacho Martínez F. Frontal fibrosing alopecia: a survey in 16 patients[J]. J Eur Acad Dermatol Venereol, 2005, 19(6):700-705.
[23] 赵玉萍,涂平,杨淑霞,等. 雄激素受体CAG多态性与男性型脱发的关系[J]. 中国皮肤性病学杂志, 2007, 21(11):654-656.
[24] 蔡泽明, 赵莹, 杨建, 等. 斑秃患者189例的疗效与临床和病理的相关关系[J]. 中国皮肤性病学杂志, 2011, 25(7):538-541.
[25] Miteva M, Tosti A. The follicular triad: a pathological clue to the diagnosis of early frontal fibrosing alopecia[J]. Br J Dermatol, 2012, 166(2):440-442.
[26] Cranwell WC, Sinclair R. Familial frontal fibrosing alopecia treated with dutasteride,minoxidil and artificial hair transplantation[J]. Australas J Dermatol, 2016, 58(3):e94-e96.

相似文献/References:

[1]施健,缪旭,花志祥,等.角化棘皮瘤43例临床及病理分析[J].中国皮肤性病学杂志,2017,(04):400.[doi:10.13735/j.cjdv.1001-7089.201610008]
 SHI Jian,MIAO Xu,HUA Zhi-xiang,et al.Clinical and Pathological Analysis with 43 Cases of Keratoacanthoma[J].The Chinese Journal of Dermatovenereology,2017,(05):400.[doi:10.13735/j.cjdv.1001-7089.201610008]
[2]李凌佳,张胜,刘彤云,等.综合性医院皮肤科门诊麻风78例临床与病理分析[J].中国皮肤性病学杂志,2017,(05):514.[doi:10.13735/j.cjdv.1001-7089.201608050]
 LI Ling-jia,ZHANG Sheng,LIU Tong-yun,et al.Clinico-Histopathological Analysis of 78 Out Patients with Leprosy at Department of Dermatology at A General Hospital[J].The Chinese Journal of Dermatovenereology,2017,(05):514.[doi:10.13735/j.cjdv.1001-7089.201608050]
[3]邵依,李建国,袁星海,等.环状肉芽肿81例临床及组织病理分析[J].中国皮肤性病学杂志,2017,(08):853.[doi:10.13735/j.cjdv.1001-7089.201701064]
 SHAO Yi,LI Jian-guo,YUAN Xing-hai,et al.Clinical and Pathological Analysis of 81 Cases of Granuloma Annulare[J].The Chinese Journal of Dermatovenereology,2017,(05):853.[doi:10.13735/j.cjdv.1001-7089.201701064]
[4]河北省人民医院皮肤科,河北 石家庄 000.类似股癣的二期梅毒疹1例并文献复习[J].中国皮肤性病学杂志,2013,(07):54.
 CAI Li,ZHOU Yue,LIU Ping-ying,et al.A Case Report of Secondary Syphilis Similar to Tinea Cruris and Review of the Literature[J].The Chinese Journal of Dermatovenereology,2013,(05):54.
[5]傅强.肢端色痣357例分析[J].中国皮肤性病学杂志,2013,(10):51.
 FU Qiang.Analysis of Acral Nevi in 357 Cases[J].The Chinese Journal of Dermatovenereology,2013,(05):51.
[6]郑力强,韩向春,阮仕荣,等.毛囊皮脂腺囊性错构瘤2例并文献复习[J].中国皮肤性病学杂志,2013,(11):1146.
 ZHENG Li-qiang,HAN Xiang-chun,RUAN Shi-rong,et al.Folliculosebaceous Cystic Hamartoma 2 Case Reports and Review of Literatures[J].The Chinese Journal of Dermatovenereology,2013,(05):1146.
[7]张雪英,马春光,韩建德.遗传性血管性水肿1例及家系分析[J].中国皮肤性病学杂志,2014,(06):551.[doi:10.13735/j.cjdv.1001-7089.2014.0551]
 ZHANG Xue-ying,MA Chun-guang,HAN Jian-de.A Case of Hereditary Angioedema and Pedigree Analysis[J].The Chinese Journal of Dermatovenereology,2014,(05):551.[doi:10.13735/j.cjdv.1001-7089.2014.0551]
[8]朱培秋,闫慧敏,赵慧娟,等.MVD基因突变所致不同临床表型的2个汗孔角化症家系[J].中国皮肤性病学杂志,2018,(08):868.[doi:10.13735/j.cjdv.1001-089.201801102]
 ZHU Peiqiu,YAN Huimin,ZHAO Huijuan,et al.Different Clinical Phenotypes of Two Chinese Families with Porokeratosis Caused by Mevalonate Diphosphate Decarboxylase(MVD)Gene Mutations[J].The Chinese Journal of Dermatovenereology,2018,(05):868.[doi:10.13735/j.cjdv.1001-089.201801102]
[9]郭碧蓉,蔡海斌,周欣,等.口腔外疣状黄瘤10例临床表现与组织病理分析[J].中国皮肤性病学杂志,2019,(06):674.[doi:10.13735/j.cjdv.1001-7089.201809027]
 GUO Birong,CAI Haibin,ZHOU Xin,et al.Clinicopathological Analysis of 10 Cases with Verrucous Xanthoma Locating in the External Position of Oral Cavity[J].The Chinese Journal of Dermatovenereology,2019,(05):674.[doi:10.13735/j.cjdv.1001-7089.201809027]
[10]张皓,付希安,王小伶,等.多发性家族性毛发上皮瘤1家系CYLD基因突变检测及文献复习[J].中国皮肤性病学杂志,2019,(11):1247.[doi:10.13735/j.cjdv.1001-7089.201903085]
 ZHANG Hao,FU Xian,WANG Xiaoling,et al.Detection of CYLD Gene Mutation in a Family with Multiple Familial Trichoepithelioma and Literature Review[J].The Chinese Journal of Dermatovenereology,2019,(05):1247.[doi:10.13735/j.cjdv.1001-7089.201903085]

备注/Memo

备注/Memo:
[基金项目] 国家自然科学基金(81573066)
[通讯作者] 章星琪,E-mail:xingqi.zhang@aliyun.com
更新日期/Last Update: 2018-05-01