[1]聂磊,孙波,郭伟.三种浓度ALA-PDT疗法对结节囊肿型痤疮患者疗效及安全性的影响[J].中国皮肤性病学杂志,2018,(04):489.[doi:10.13735/j.cjdv.1001-7089.201710099]
 NIE Lei,SUN Bo,GUO Wei.Influence of Three Concentrations of ALA-PDT Therapy on the Clinical Efficacy and Safety of Patients with Cystic Acne[J].The Chinese Journal of Dermatovenereology,2018,(04):489.[doi:10.13735/j.cjdv.1001-7089.201710099]
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三种浓度ALA-PDT疗法对结节囊肿型痤疮患者疗效及安全性的影响
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2018年04期
页码:
489
栏目:
药物与临床
出版日期:
2018-04-01

文章信息/Info

Title:
Influence of Three Concentrations of ALA-PDT Therapy on the Clinical Efficacy and Safety of Patients with Cystic Acne
作者:
聂磊孙波郭伟
[作者单位] 河南大学第一附属医院皮肤科,河南 开封 475001
Author(s):
NIE LeiSUN BoGUO Wei
Department of Dermatology,the First Affiliated Hospital of Henan University,Kaifeng 475001,China
关键词:
ALA-PDT 痤疮结节囊肿型 疗效 安全性
Keywords:
ALA-PDT Acne cystic Clinical effects Safety
分类号:
R 758.73
DOI:
10.13735/j.cjdv.1001-7089.201710099
文献标志码:
A
摘要:
目的 探讨不同浓度ALA-PDT疗法对结节囊肿型痤疮患者疗效及安全性的影响。方法 将210例结节囊肿型痤疮患者,随机分为A组(70例)、B组(70例)及C组(70例),分别采用5%、7.5%及10%ALA-PDT疗法治疗; 比较三组患者近期疗效、治疗前后皮损数量和痤疮皮损面积和严重程度指数(GAGS)评分,随访复发率及不良反应发生率。结果 B、C组患者临床治疗有效率均显著高于A组; 三组患者治疗后皮损数量和GAGS评分均显著低于治疗前; B、C组患者治疗后皮损数量和GAGS评分均显著低于A组; B、C组患者随访复发率显著低于A组; 同时A、B组患者不良反应发生率显著低于C组。以上差异均有统计学意义(P均<0.05)。结论 7.5% ALA-PDT疗法治疗结节囊肿型痤疮可有效促进皮损修复,控制皮损面积,避免远期复发,且未增加不良反应发生风险,价值优于5%和10%ALA-PDT疗法。
Abstract:
Objective To investigate the influence of different ALA-PDT therapy concentrations on the clinical efficacy and safety of patients with cystic acne.Methods Two hundreds and ten patients with cystic acne were randomly divided into 3 groups including A group(70 patients)with 5% ALA-PDT therapy,B group(70 patients)with 7.5% ALA-PDT therapy and C group(70 patients)with 10% ALA-PDT therapy.The clinical effects,the skin lesion quantity and GAGS scores before and after treatment,the recurrence rate with follow-up and the adverse effects incidence of 3 groups were compared.Results The clinical effects of B group and C group were significantly higher than A group(P<0.05).The skin lesion quantity and GAGS scores after treatment of 3 groups were significantly lower than before treatment(P<0.05).The skin lesion quantity and GAGS scores after treatment of B group and C group were significantly lower than A group(P<0.05).The recurrence rate with follow-up of B group and C group were significantly lower than A group(P<0.05).The adverse effects incidence of A group and B group were significantly lower than C group(P<0.05).Conclusion Compared with 5% and 10% ALA-PDT therapy,7.5% ALA-PDT therapy concentrations in the treatment of patients with cystic acne can efficiently promote the skin repair,control the area of skin lesions,avoid long-term recurrence and not increase the adverse reactions risk.

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备注/Memo

备注/Memo:
[基金项目] 开封市科技发展计划项目(1403130)
更新日期/Last Update: 2018-04-01