[1]王文欢,王红梅.表观遗传学在系统性硬皮病和系统性红斑狼疮中的研究状况[J].中国皮肤性病学杂志,2018,(03):341-345.[doi:10.13735/j.cjdv.1001-7089.201608134]
 WANG Wenhuan,WANG Hongmei.Epigenetic in the Autoimmune Skin Diseases[J].The Chinese Journal of Dermatovenereology,2018,(03):341-345.[doi:10.13735/j.cjdv.1001-7089.201608134]
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表观遗传学在系统性硬皮病和系统性红斑狼疮中的研究状况
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2018年03期
页码:
341-345
栏目:
综述
出版日期:
2018-03-01

文章信息/Info

Title:
Epigenetic in the Autoimmune Skin Diseases
作者:
王文欢1王红梅2
1.天津中医药大学, 天津 300120; 2.天津市中医药研究院附属医院, 天津 300120
Author(s):
WANG Wenhuan1 WANG Hongmei2
1.Tianjin University of Traditional Chinese Medicine,Tianjing 300120,China; 2. Tianjin Acedemy of Traditional Chinese Medicine Affiliated Hospital,Tianjing 300120,China
关键词:
表观遗传学 组蛋白乙酰化 DNA甲基化 miRNAs调控 自身免疫性皮肤疾病 红斑狼疮系统性 硬皮病系统性
Keywords:
Epigenetics Histone acetylation DNA methylation miRNAs regulation Autoimmune diseases Lupus erythematosussystemic Sclerosissystemic
分类号:
R 593.25; R 593.24
DOI:
10.13735/j.cjdv.1001-7089.201608134
文献标志码:
A
摘要:
表观遗传即在不改变DNA序列的情况下,产生基因表达变化并遗传给下一代,其包括组蛋白修饰、DNA甲基化、非编码RNA以及染色质重塑等途径。蛋白质乙酰化是指在乙酰基转移酶的作用下,在蛋白质赖氨酸残基上添加乙酰基的过程; DNA甲基化是指在DNA甲基化转移酶(DNMTs)的催化下,S-腺苷甲硫氨酸(SAM)为甲基供体将甲基转移至DNA碱基上的一种表观遗传修饰方法; 而miRNA是通过与靶细胞mRNA的3'-UTR碱基互补配对,引起靶细胞mRNA降解或者抑制其翻译而对基因进行转录后的表达调控。自身免疫应答过分强烈导致相应的组织器官损伤及功能障碍所引起的疾病称为自身免疫病,在皮肤科诊疗临床中常见的自身免疫性皮肤疾病有系统性硬皮病、系统性红斑狼疮及白癜风等。为进一步揭示表观遗传在自身免疫性疾病中所起到的作用,本文将从表观遗传学的机制方面总结有关自身免疫性皮肤疾病的发病机制,综述如下。
Abstract:
Epigenetics is the study of heritable changes in gene function viahistone modification, DNA methylation, noncoding RNA and chromatin remodeling etc., without changing the DNA sequence.Histone acetylation refers to the process adding acetyl groups on the protein lysine residues via acetyl transferase, while DNA methylation is an epigenetic modification method using the S-adenosine methionine(SAM)as methyl donor transferred to the DNA bases under catalysis of the DNA methylation transferase(DNMTs). The miRNA regulates gene expression bycomplementary bases pairing with mRNA 3'- UTR, leading to mRNA degradation or inhibition of its translation in target cells.Autoimmune disease is a disease caused by the immuneresponse to its own antigens, resulting in its autologous tissue damage and functional alterations. There are many autoimmune dermatoses, including systemic lupus erythematosus, systemic sclerosis and vitiligo.To further understand the role of epigenetic in autoimmune diseases,we will summarize the pathogenesis of autoimmune skin diseases in the aspect of epigenetic mechanisms.

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备注/Memo

备注/Memo:
[基金项目] 国家自然科学基金(81573991); 天津市卫生和计划生育委员会中医中西医结合科研课题(2015002)
[通讯作者] 王红梅, E-mail:13821085895@163.com
更新日期/Last Update: 2018-03-01