[1]王小云,尹光文,张华.误诊为线状IgA大疱性皮病的大疱性系统性红斑狼疮1例[J].中国皮肤性病学杂志,2018,(02):200-202.[doi:10.13735/j.cjdv.1001-7089.201705072]
　WANG Xiaoyun,YIN Guangwen,ZHANG Hua.A Case of Bulloussystemic Lupus Erythematosus Misdiagnosed as Linear IgA Bullous Dermatosis[J].The Chinese Journal of Dermatovenereology,2018,(02):200-202.[doi:10.13735/j.cjdv.1001-7089.201705072]
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误诊为线状IgA大疱性皮病的大疱性系统性红斑狼疮1例
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2018年02期
页码:
200-202
栏目:
病例报告
出版日期:
2018-02-01

文章信息/Info

Title:
A Case of Bulloussystemic Lupus Erythematosus Misdiagnosed as Linear IgA Bullous Dermatosis
作者:
王小云; 尹光文; 张华
郑州大学第一附属医院皮肤科,河南 郑州 450052
Author(s):
WANG Xiaoyun; YIN Guangwen; ZHANG Hua
Department of Dermatology and Venereology,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China
关键词:
大疱性;  红斑狼疮; 系统性;  大疱性皮病; 线状IgA
Keywords:
Bullous;  Lupus erythematosus; Systemic;  Bullous dermatosis; Linear IgA
分类号:
R 593.24+1
DOI:
10.13735/j.cjdv.1001-7089.201705072
文献标志码:
B
摘要:
患者男,20岁,面部、胸前皮肤出现孤立或半环状排列的水疱7天,曾诊断为线状IgA大疱性皮病(linear IgA bullous dermatosis,LABD),后经实验室检查患者外周血白细胞2.50×109/L,血小板65×109/L,ANA 1:640,抗dsDNA抗体阳性,尿蛋白(3+)。组织病理示:表皮下水疱形成,真皮浅层及血管周可见淋巴细胞、中性粒细胞浸润,免疫荧光(direct immunofluorescence,DIF)基底膜带有IgG,IgA和C3均呈线状沉积,确诊为大疱性系统性红斑狼疮(bullous systemic lupus erythematosus,BSLE)。予甲泼尼龙、羟氯喹等治疗7天,皮损全部消退,随访未见新发水疱。
Abstract:
A 20-year-old man presented with isolated or semi-circular formed blisters on his face and anterior thorax for 7 days.He had been diagnosed as IgA bullousdermatosis.Laboratory analysis revealed white blood test(WBC)2.50×109/L,platelet 65×109/L,ANA 1:640,ds-DNA(+),urineprotein(3+).The histopathological examination showed subepidermal bullae,with prominent infiltration of neutrophil and lymphocytes in the upper dermis and perivascular locations.DIF revealed linear depostion of IgA,IgG and C3in the basement zone membrane.A diagnosis of bullous systemic lupus eyrthematosuts was finally established.The skin rashes resolved dramatically with the treatment of methylprednisolone and hydroxychloroquine for one week,and no new blisters were followed.

参考文献/References:

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备注/Memo

备注/Memo:
[通讯作者] 尹光文,E-mail:gwyin67@126.com
更新日期/Last Update: 1900-01-01