[1]焦林君,李金梅.果酸换肤并粉刺挤压治疗闭合性痤疮133例疗效观察[J].中国皮肤性病学杂志,2017,(12):1318-1320.[doi:10.13735/j.cjdv.1001-7089.201705014]
 JIAO Lin-jun,LI Jin-mei.Efficacy and Safety of Alpha Hydroxyl Acid Combined with Acne Extrusion for 133 Patients with Close Acne[J].The Chinese Journal of Dermatovenereology,2017,(12):1318-1320.[doi:10.13735/j.cjdv.1001-7089.201705014]
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果酸换肤并粉刺挤压治疗闭合性痤疮133例疗效观察
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《中国皮肤性病学杂志》[ISSN:1001-7089/CN:61-1197/R]

卷:
期数:
2017年12期
页码:
1318-1320
栏目:
临床经验
出版日期:
2017-11-20

文章信息/Info

Title:
Efficacy and Safety of Alpha Hydroxyl Acid Combined with Acne Extrusion for 133 Patients with Close Acne
作者:
焦林君李金梅
内蒙古科技大学包头医学院第一附属医院皮肤科,内蒙古 包头014010
Author(s):
JIAO Lin-junLI Jin-mei
The Affiliated Hospital of Baotou Medical College,Baotou 014010,China
关键词:
粉刺挤压术 果酸 痤疮
Keywords:
Acne extrusion Alpha hydroxyl acid Acne
分类号:
R 758.73
DOI:
10.13735/j.cjdv.1001-7089.201705014
文献标志码:
B
摘要:
目的 观察果酸换肤联合粉刺挤压术治疗闭合性痤疮的临床疗效,评估其安全性。方法 选取以白头粉刺为主要皮损的痤疮患者133例,并将其随机分成两组,A组单用粉刺挤压术进行治疗,B组采取果酸换肤联合粉刺挤压术进行治疗,每3周1次,4次为1个疗程。结果 治疗2次后,A组的有效率和基愈率分别为17.46%和4.76%,B组分别为20.00%和5.71%; 治疗4次后,A组的有效率和基愈率分别为46.03%和23.81%,B组分别为65.71%和42.86%。两组治疗2次后的有效率和基愈率比较差异均无统计学意义(P>0.05),B组治疗4次后的有效率和基愈率均显著高于A组,治疗2次和4次时的有效率进行比较,后者较前者明显增高,差异有统计学意义(P<0.05)。不良反应主要出现在B组,多出现于高浓度果酸治疗后,A组可见粉刺挤压部位局部疼痛。结论 果酸换肤联合粉刺挤压术可以有效治疗闭合性痤疮,较高浓度的果酸可以增强治疗效果,但是,不良反应亦增加。
Abstract:
Objective To assess the efficacy and safety of alpha hydroxyl acid combined with acne extrusion for close acne. Methods One hundred and thirty-three subjects mainly with close acne were randomly divided group A treated with acne extrusion alone and group B treated with alpha hydroxyl acid combined with acne extrusion. Both groups were treated once every 3 weeks,4 treatments per course. Results After two treatments,the effective and cure rates were similar between group A and B(effective rate:17.46% vs. 20.00%; cure rate:4.76% vs. 5.71%). But after four treatments,both effective and cure rates were significantly higher in group B than in group A(effective rate:65.71% vs. 46.03%,P<0.05; cure rate:42.86% vs. 23.81%,P<0.05). The effective rates were higher after 4 treatments than 2 treatments. High incidence of adverse reactions occurred following treatment with high concentration of alpha hydroxyl acid in group B,while localized pain developed on the extrusion sites in group A. Conclusion Treatments with alpha hydroxyl acid combined with acne extrusion are safe and effective for close acne. High concentration of alpha hydroxyl acid is more effective,but with a higher incidence of adverse reactions.

参考文献/References:

[1] 黄玉成,李红文,李雪莉,等.果酸换肤联合强脉冲光治疗痤疮的临床观察[J].中华皮肤科杂志,2013,46(7):515-516.
[2] 赵辨.中国临床皮肤病学[M].南京:江苏科学技术出版社,2010:1165-1169.
[3] 吴琰瑜,王学民,程英,等.轻中度痤疮患者皮肤生理参数特征[J]. 中华皮肤科杂志,2011,44(6):427-429.
[4] Kessledr E,Flanagan K,Chia C,et al. Comparison of alphaand and beta-hydmxy acid chemical peels in the treatment of mild to moderately severe facial acne vulgaris[J]. Dermatol Surg,2008,34(1):45-50.
[5] Takenaka Y,Hayashi N,Takeda M,et al. Glycolic acid chemical peeling improves inflammatory acne eruptions through its inhibitory and bactericidal effect of Propionibacterium acnes[J]. J Dermatol,2012,39(4):350-354.
[6] 李琳,李恒进,罗燕萍.不同浓度果酸对痤疮丙酸杆菌体外抑菌作用的实验研究[J].中国麻风皮肤病杂志,2007,23(6):482-483.
[7] 孟林,白云平,葛双启. 果酸在化妆品中的运用[J].化学与生物工程,2005,22(4):45-46.
[8] 曹文婷,毛越苹.果酸治疗痤疮的疗效观察[J].中华医学美学美容杂志,2012,18(5):353-356.
[9] 郑小帆,吴玉清,黄英举,等.果酸治疗痤疮的疗效及安全性研究[J].临床合理用药,2014,74(4):28-29.
[10] 屈园园,梁俊琴,孙志文,等. 5%果酸治疗轻、中度痤疮58例临床观察[J].中国皮肤性病学杂志,2014,28(9):981-983.

备注/Memo

备注/Memo:
[通讯作者] 李金梅,E-mail:ljm0708@163.com
更新日期/Last Update: 2017-12-01